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Adipose tissue retains an epigenetic memory of obesity after weight loss

nature.com

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Re: Adipose tissue retains an epigenetic memory of obesity after weight loss

#301

Post by cultofmetatron »

darksaints wrote: post #204
meindnoch wrote: post #82

Well, yeah. Adipocytes multiply when you get fat. But when you lose weight, they don't apoptose, they just shrink in volume by giving up their lipid stores.

I kinda went down a rabbit hole a while back with certain treatments that can kill adipocytes, as there's actually some significant research backing both heat-generating and cold-generating treatments. They do kill fat cells, and they are flushed out of the body. But people who undergo such treatments do not lose fat. At best, these devices can reshape your fat, pulling it out of one area and distributing it more eve…

seems like it would be a good idea then to do a heavy strength based training session and fast before getting this done to maximize effectiveness. Those liberated triglycerides would be sucked up by muscle tissue to be used for repair.

Re: Adipose tissue retains an epigenetic memory of obesity after weight loss

#302

Post by snapcaster »

johnisgood wrote: post #291
gamblor956 wrote: post #272

Earlier quoted context omitted.

That only looks like about 2000 calories a day, which is the recommended caloric intake for the average sedentary adult man. If you're trying to bulk, you need to be looking at 2500 or more calories a day, plus additional for any calories burned by exercise. (With a surplus of 1000/calories a day you'll be gaining more fat than muscle unless you're still in puberty. Sometimes that may be what you want.)

It just seems like I have to spend most of my day eating. :/

I think part of this can be solved by "hacks" the primary one being throwing olive oil on random stuff you eat. Another one is "drinking your calories". Basically all the things people tell you to do to lose weight, do the opposite

Re: Adipose tissue retains an epigenetic memory of obesity after weight loss

#303

Post by snapcaster »

david-gpu wrote: post #68
senko wrote: post #37

Earlier quoted context omitted.

> It's not about the weight, it's about the exercise. You cannot outrun a fork.

Tell that to all the skinny endurance weekend warriors who fuel their exercise with huge amounts of sugary drinks and gummy bears. If you are curious, read about the function of GLUT4 in the membrane of skeletal muscles. Reality is more complex than memetic one-liners.

Dedicated athletes are obviously not who we're talking about so why bring it up?

Re: Adipose tissue retains an epigenetic memory of obesity after weight loss

#304

Post by johnisgood »

snapcaster wrote: post #302
johnisgood wrote: post #291

Earlier quoted context omitted.

It just seems like I have to spend most of my day eating. :/

I think part of this can be solved by "hacks" the primary one being throwing olive oil on random stuff you eat. Another one is "drinking your calories". Basically all the things people tell you to do to lose weight, do the opposite

I get what you mean, sounds reasonable. :D

Re: Adipose tissue retains an epigenetic memory of obesity after weight loss

#305

Post by gregoryl »

autoexec wrote: post #288
gregoryl wrote: post #155

Earlier quoted context omitted.

Anecdotally (but an experience shared at by at least some other long distance runners), when I get quite far into a calorie deficit via exercise, my brain will start suggesting shortcuts - urges to cut the corner on a trail, take a shorter path back etc. Its quite interesting!

Considering the amount of effort it traditionally took to get food it's a shame that our brains would want us to be less active when it could otherwise start suggesting that we be even more active to find/hunt food.

The suggestions generally still work towards my goal; this is a different phenomena to "holy shit the consciousness is trying to kill us again" panic switch. Maybe its some low level optimisation to reduce energy expenditure, so we can last longer, and find even more food!

Re: Adipose tissue retains an epigenetic memory of obesity after weight loss

#306

Post by kbelder »

agos wrote: post #20
paulpauper wrote: post #9

The more you research/learn about obesity, the worse it is, much like smoking. One of the most depressing stats is that dieting does not get easier with time. The probability of eventually regaining all the weight eventually converges to 100%. Even if you're successful for 2 years, people still regain by year 4, 5, etc. The body never resists trying to regain the weight. GLP-1 drugs are the best hope yet.

absolutely. and yet people will still say "just eat less"! Imagine telling a person who smokes "just smoke less"

That is the key to stopping smoking.

Telling them they can't possibly smoke less through willpower is incredibly harmful. Same with eating.

Re: Adipose tissue retains an epigenetic memory of obesity after weight loss

#307

Post by david-gpu »

snapcaster wrote: post #303
david-gpu wrote: post #68

Earlier quoted context omitted.

Tell that to all the skinny endurance weekend warriors who fuel their exercise with huge amounts of sugary drinks and gummy bears. If you are curious, read about the function of GLUT4 in the membrane of skeletal muscles. Reality is more complex than memetic one-liners.

Dedicated athletes are obviously not who we're talking about so why bring it up?

So you can't run away from a bad diet... Except when you can, but that is "obviously not who we are talking about".

Maybe that meme needs to die for good, instead.

Re: Adipose tissue retains an epigenetic memory of obesity after weight loss

#308

Post by jonplackett »

e40 wrote: post #200
jonplackett wrote: post #198

Earlier quoted context omitted.

This worked for me for a while but I learned to love dark chocolate toooooo much. I can now eat a 100g bar of 100% chocolate in a single sitting if I feel like it… And that’s 55g of fat, so more or less the fat I should be eating in a whole day.

Wow!! I feel queasy if I eat more than 1/2 a bar of the 90%. It also completely takes the edge off my hunger, which is great for me.

I think I started getting addicted to the caffeine

Re: Adipose tissue retains an epigenetic memory of obesity after weight loss

#309

Post by LtdJorge »

meindnoch wrote: post #236
eurekin wrote: post #211

Earlier quoted context omitted.

I have no real or deep knowledge, just some casual pop news reading. Isn't ketosis the state, in which the body switches to fat as the primary fuel?

It is. But it's hard to maintain. I was in ketosis for a month via diet (verified with urine strips twice a day) and it was a struggle to figure out what to eat. Camembert, bacon-wrapped chicken and eggs gets boring after a while. Our civilization runs on carbohydrates, for better or worse.

Do you not like meat?

Re: Adipose tissue retains an epigenetic memory of obesity after weight loss

#310

Post by kridsdale1 »

greenavocado wrote: post #282
kridsdale1 wrote: post #213

Earlier quoted context omitted.

I am a data point of resuscitation of fertility. Confirmed to be shooting blanks after years of juice, and decided to see if I could reactivate by following the broscience (and all the pubmed papers) on the topic. An aggressive protocol of HCG and HMG (analogues for FSH and LH in the pituitary) reactivated the testes to get back to spermatogenesis and T production after about 5 years of complete dormancy. It took abo…

To clarify, did you try to conceive approximately four times (four months)? Because from what I hear that isn't exactly unheard of in people that aren't on the juice.

No, it was about a year of multiple attempts per ovulation before I decided to get serious and bring my whole HTPA under control.
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