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Adipose tissue retains an epigenetic memory of obesity after weight loss

nature.com

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Re: Adipose tissue retains an epigenetic memory of obesity after weight loss

#281

Post by asoneth »

_Algernon_ wrote: post #52
agos wrote: post #20

Earlier quoted context omitted.

absolutely. and yet people will still say "just eat less"! Imagine telling a person who smokes "just smoke less"

That's... A completely reasonable thing to say..

That depends on your definition of "reasonable". Every single person I have met who is struggling to lose weight is attempting to consume fewer calories. Telling them to "just eat less" provides no novel information or actionable strategies. At best it makes you sound like the kind of person who most people avoid because you prefer being right to being helpful.

Re: Adipose tissue retains an epigenetic memory of obesity after weight loss

#282

Post by greenavocado »

kridsdale1 wrote: post #213
Aurornis wrote: post #182

Earlier quoted context omitted.

Testicular atrophy and HPT axis suppression is a thoroughly documented side effect of TRT and steroids. Even beginner bodybuilders know that taking steroids will crush their natural testosterone production. They can kind of bring it back by taking short courses and using certain medications after the cycle, but most discover that some permanent damage is being done with each cycle. There are two problems with framing…

I am a data point of resuscitation of fertility. Confirmed to be shooting blanks after years of juice, and decided to see if I could reactivate by following the broscience (and all the pubmed papers) on the topic. An aggressive protocol of HCG and HMG (analogues for FSH and LH in the pituitary) reactivated the testes to get back to spermatogenesis and T production after about 5 years of complete dormancy. It took abo…

To clarify, did you try to conceive approximately four times (four months)? Because from what I hear that isn't exactly unheard of in people that aren't on the juice.

Re: Adipose tissue retains an epigenetic memory of obesity after weight loss

#283

Post by MrGilbert »

sleepyguy wrote: post #274
meindnoch wrote: post #237

Earlier quoted context omitted.

Yeah, but fasting is extremely unpleasant.

You get to know yourself well after about 5 days of zero food..... :))

I did that, and it helped to kickstart further weightloss. I was surprised how fast my body got rid of stored water, and how quickly I lost fat in the upper body region, primarily around my face, neck and shoulder.

Re: Adipose tissue retains an epigenetic memory of obesity after weight loss

#284

Post by autoexec »

vimus wrote: post #276
delecti wrote: post #271

Earlier quoted context omitted.

> I think you can basically make a case for including or excluding transwomen in women's sports depending on whether you think inclusion or fairness is most important. A pretty wide spread of sports have allowed trans women*, and they have not dominated. If trans women did have an outsized performance in women's sports, there'd be examples to point to. I don't think you can make an evidence-based case for fairness an…

> In weightlifting, probably the sport I'd expect an unfair advantage to make itself most apparent, Laurel Hubbard got a DNF in the Olympics, and did merely pretty good in several other events. On the contrary, Laurel Hubbard is a good example of how apparent this male physical advantage is when male athletes are allowed to compete in the female category. Here's a chart showing ranked lifts for both men's and women's…

Out of curiosity, do you have a link to the source of that graph or the name of the researcher?

Re: Adipose tissue retains an epigenetic memory of obesity after weight loss

#285

Post by monkeycantype »

wonderwonder wrote: post #105
monkeycantype wrote: post #80

Earlier quoted context omitted.

I had this same experience, but I have not continued to take the medication after a short experiment. I found I could get a similar outcome (subjective experience) through my food selection Today I’ve eaten around 2kg of vegetables today (zucchini, capsicum, eggplant, cauliflower, spinach) all of which was under 500 calories, and I’ve eaten fish. If I eat a massive amount of vegetables and get ~200g protein, I don’t…

My brother's family has done something similar although in a different direction. They have been strictly carnivore for several years now. Able to eat large amounts of food while keeping calories low and feeling satiated. It's worked well for them. I'll look at that study you mentioned, thank you.

leptin deficiency is rare, so supplementation does not produce an effect in most people.

https://www.nejm.org/doi/full/10.1056/NEJM199909163411204

There is more information about the family involved out there, but I can't remember where I read about it.

A thing I found interesting about the genetics of hunger, is the concept of mongenetic, v polygenetic traits Monogenetic traits - a variation in a single gene is has an observed often severe impact. Polygenetic traits - variations in a large number of genes and environmental are contributing In reality these traits exist on a spectrum of severity. The more sublte the impact of a gene the more people you need to study to tease out the influence of the gene, so monogenetic traits tend to be discovered first.

Re: Adipose tissue retains an epigenetic memory of obesity after weight loss

#286

Post by autoexec »

e40 wrote: post #116
spoiler wrote: post #2

As someone who's struggled with weight loss, and have known others to struggle with it well, I think we colloquially called this "slow metabolism". It always did feel like it was easier to gain weight than lose it, especially fat weight and not muscle weight for me. I was recently sent a video about fat adaptation (basically teaching your body to be better at burning fat) by a very fit friend, but I wonder how much o…

For me, sugar was the reason I couldn't lose weight. I got a CGM (continuous glucose monitor) and got my blood sugar under control, and with very little effort I lost a lot of weight. I use 90% cacao Lindt to control my sweet tooth. 1/2 the bar has 4g of sugar, and I consume it over hours. It also has the side effect of reducing my hunger. If you eat much of 90% chocolate, it makes you feel nausea. The trick is to pu…

I'm a chocolate fan myself and it was something I used to buy often, but just as I started getting into the hard stuff (80% or higher) I learned about all the problems with heavy metals in dark chocolate and specifically in Lindt, and then later learned about the use of child slaves which is an industry wide issue and not exclusive to Lindt/Russell Stover/Ghirardelli/Lindor although Lindt and Hershey are reportedly worse than other brands.

You can find brands that claim to be more ethical in terms of sourcing their cocoa, but the smaller brands that do are also less likely to have been tested for heavy metals.

While it's unclear how harmful the heavy metals would be to me specifically at the amounts I was eating, the whole thing kind of put me off chocolate in general and dark chocolate in particular. I rarely have it anymore.

Re: Adipose tissue retains an epigenetic memory of obesity after weight loss

#287

Post by scns »

HorizonXP wrote: post #258
spoiler wrote: post #2

As someone who's struggled with weight loss, and have known others to struggle with it well, I think we colloquially called this "slow metabolism". It always did feel like it was easier to gain weight than lose it, especially fat weight and not muscle weight for me. I was recently sent a video about fat adaptation (basically teaching your body to be better at burning fat) by a very fit friend, but I wonder how much o…

I have had a slow metabolism since I was a teenager. I don't think I've ever experienced a day in my life where I haven't thought about my weight, body composition, or felt guilty about eating food. And I'm not even that big. I've just never had the physique I wanted, and I always attributed it to having a slow metabolism. I'm turning 40 in May, so since the start of February, I've finally pulled up my bootstraps and…

Muscles are heavier than fat which makes weight an unreliable indicator for progress.

Re: Adipose tissue retains an epigenetic memory of obesity after weight loss

#288

Post by autoexec »

gregoryl wrote: post #155
ngd wrote: post #89

Earlier quoted context omitted.

There is also a conflation of a slowing metabolism and low energy availability, which can reduce the amount of energy expended during the day (because you feel tired and do less). It can be quite subtle but when I've done some extended periods in a calorie deficit I start to notice subtle things, like a propensity to sit a bit longer, or to reduce my overall body movements. My resting metabolism is the same (I've had…

Anecdotally (but an experience shared at by at least some other long distance runners), when I get quite far into a calorie deficit via exercise, my brain will start suggesting shortcuts - urges to cut the corner on a trail, take a shorter path back etc. Its quite interesting!

Considering the amount of effort it traditionally took to get food it's a shame that our brains would want us to be less active when it could otherwise start suggesting that we be even more active to find/hunt food.

Re: Adipose tissue retains an epigenetic memory of obesity after weight loss

#289

Post by strken »

HorizonXP wrote: post #258
spoiler wrote: post #2

As someone who's struggled with weight loss, and have known others to struggle with it well, I think we colloquially called this "slow metabolism". It always did feel like it was easier to gain weight than lose it, especially fat weight and not muscle weight for me. I was recently sent a video about fat adaptation (basically teaching your body to be better at burning fat) by a very fit friend, but I wonder how much o…

I have had a slow metabolism since I was a teenager. I don't think I've ever experienced a day in my life where I haven't thought about my weight, body composition, or felt guilty about eating food. And I'm not even that big. I've just never had the physique I wanted, and I always attributed it to having a slow metabolism. I'm turning 40 in May, so since the start of February, I've finally pulled up my bootstraps and…

In terms of where carbs fit in, you're eating 200g of protein a day, which at a guess is 2x to 4x your lean body mass in kg. I'm not saying that it's wrong, it's probably very effective, but the average diet probably swaps that (historically very expensive) protein out for (historically very cheap) bread and rice.

Re: Adipose tissue retains an epigenetic memory of obesity after weight loss

#290

Post by sph »

dsmurrell wrote: post #38
spoiler wrote: post #2

As someone who's struggled with weight loss, and have known others to struggle with it well, I think we colloquially called this "slow metabolism". It always did feel like it was easier to gain weight than lose it, especially fat weight and not muscle weight for me. I was recently sent a video about fat adaptation (basically teaching your body to be better at burning fat) by a very fit friend, but I wonder how much o…

Please share your bro science video. I need it :)

If you want the serious science about low carb/keto, I recommend the “Low Carb Down Under” channel on Youtube.
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