Adipose tissue retains an epigenetic memory of obesity after weight loss

Post by eurekin » Thu, Apr 17, 2025, 5:07 PM UTC

meindnoch wrote: post #208

darksaints wrote: post #204

Earlier quoted context omitted.

I kinda went down a rabbit hole a while back with certain treatments that can kill adipocytes, as there's actually some significant research backing both heat-generating and cold-generating treatments. They do kill fat cells, and they are flushed out of the body. But people who undergo such treatments do not lose fat. At best, these devices can reshape your fat, pulling it out of one area and distributing it more eve…

Interesting! Why can't we just remove the triglycerids from the blood before they trigger adipogenesis? Basically we need a form of dialysis.

Post by kridsdale1 » Thu, Apr 17, 2025, 5:18 PM UTC

Aurornis wrote: post #182

ben7799 wrote: post #164

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I can't remember exactly what I was listening to, maybe some kind of NPR podcast. But the doctor was mentioning that none of the influencers influencing young people to try T and Steroids (which is rampant right now) are ever mentioning that you are on a ticking clock to infertility as soon as you start this stuff. Some people can regain their fertility but it might take years, and some people are going to be permane…

Testicular atrophy and HPT axis suppression is a thoroughly documented side effect of TRT and steroids. Even beginner bodybuilders know that taking steroids will crush their natural testosterone production. They can kind of bring it back by taking short courses and using certain medications after the cycle, but most discover that some permanent damage is being done with each cycle. There are two problems with framing…

Post by hooverd » Thu, Apr 17, 2025, 5:29 PM UTC

pif wrote: post #29

paulpauper wrote: post #9

The more you research/learn about obesity, the worse it is, much like smoking. One of the most depressing stats is that dieting does not get easier with time. The probability of eventually regaining all the weight eventually converges to 100%. Even if you're successful for 2 years, people still regain by year 4, 5, etc. The body never resists trying to regain the weight. GLP-1 drugs are the best hope yet.

> One of the most depressing stats is that dieting does not get easier with time. Yeah, I've tried several times under medical control. I kept asking my supervising doctor: "When is the constant hunger going to get better?" And the answer was always in the range of a few weeks to several months. But that moment never came... never! And, in the end, all the kilograms I had lost along the route always found their way b…

Post by delecti » Thu, Apr 17, 2025, 5:33 PM UTC

loeg wrote: post #209

delecti wrote: post #205

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Though that also comes with male-pattern skeletal growth. So unless your body still has elevated/male-level T levels, you're carrying around a disproportionately heavy skeleton which negates the advantage. If the net effect were actually an advantage, you'd expect the womens' sports which are allowing trans women to be dominated by them, but they really just aren't. Additionally, trans women on HRT typically have the…

> Though that also comes with male-pattern skeletal growth. So unless your body still has elevated/male-level T levels, you're carrying around a disproportionately heavy skeleton which negates the advantage. The male-pattern skeletal growth isn't necessarily a disadvantage. E.g., narrower hips and stronger bones is likely an advantage in running. > If the net effect were actually an advantage, you'd expect the womens…

Post by bluecheese452 » Thu, Apr 17, 2025, 5:43 PM UTC

sethammons wrote: post #34

paulpauper wrote: post #11

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metabolism is orthogonal . It's possible to have a fast metabolism and still be obese if you're eating at a surplus. But it's also possible people with faster metabolisms may be more successful at weight loss if already obese. So a 300-lbs person who eats 10,000 calories/day to be weight stable will find it easier to lose weight compared to to a 300 lbs person who is stable at 4,000 cal/day. This can also explain how…

10k calories a day is what a black bear eats preparing for hibernation. And it is what Michael Phelps would eat daily when training in the pool for hours on end. Obese people can remain obese eating 1000 calories a day. I recall one episode of My 600lb Life and the show's featured person that day was at 900 or 1200 calories a day and still didn't lose weight. Might have still been gaining. It is a dynamic system. Peo…