Ozempic drug supresses desire to smoke, drink and more? • Hacker News Board

Re: Ozempic drug supresses desire to smoke, drink and more?

#301

Post by hombre_fatal » Sat, May 20, 2023, 5:35 AM UTC

Jun8 wrote: post #178

So, instead is suppressing the desire to eat, how about inventing a drug that blocks the absorption or breakdown of carbohydrates in the gut? Or maybe control the gut biome so that growth of bacteria that breaks down high calorie food is minimized. Is this faster-than-light-like impossible daydream or is there any plausible path to it?

Imagine the side effects of food passing through the gut without being broken down.

Reminds me of Olestra, the zero calorie oil substitute that failed because of similar sounding side effects. Olestra wasn't consumed/absorbed in the gut so you'd just shit out oil and your half digested food would glide out with it since it didn't block stomach emptying like real food.

Re: Ozempic drug supresses desire to smoke, drink and more?

#302

Post by pton_xd » Sat, May 20, 2023, 5:36 AM UTC

pixl97 wrote: post #101

NickC25 wrote: post #82

Earlier quoted context omitted.

Probably because people aren't acting on it, or sticking with it long enough to actually see results. Especially in today's world when they can just take a pill and loose 10-15 pounds, nobody wants to do something they probably don't like doing (consistent exercise or healthy eating) as part of a short-term or long-term process. A lot of people, especially those in food deserts or without access to adequate nutrition…

Weight has been increasing for nearly 40 years now in the US among all groups. Trying to point this out as any kind of individual failure just has not, and is not going to work. It's tantamount to telling someone to stop smoking in 1950. Yes, some people did manage to, but the vast majority stopped smoking when their lungs no longer supported them living. When pretty much everywhere you go is plastered in signs sayin…

> Weight has been increasing for nearly 40 years now in the US among all groups.

Although interestingly it's still far lower among Asians in the US than any other group. Why is that?

[1] https://www.cdc.gov/obesity/data/adult.html

Re: Ozempic drug supresses desire to smoke, drink and more?

#303

Post by orhmeh09 » Sat, May 20, 2023, 5:37 AM UTC

cesnja wrote: post #286

orhmeh09 wrote: post #279

Earlier quoted context omitted.

What's your bloodwork and cardio like now and what does your doctor say? No fat + high carbs flies in the face of everything I've read that was published in the last 20 years. Maybe you've found another path to health?

You're confusing complex carbohydrates with sugar.

How complex are pasta, rice, pint of blueberries, 5 medium apples, 2 mangoes, and a pound of grapes?

Re: Ozempic drug supresses desire to smoke, drink and more?

#304

Post by rblatz » Sat, May 20, 2023, 5:38 AM UTC

jmpman wrote: post #151

I’ve been on Mounjaro since August. Down almost 60lbs, and it’s been a life changer. Have I had some gastrointestinal issues, sure, but expected. I feel great and my brain seems to be functioning as well as when I was in my 20’s. Now, when I go to the bar with friends, I end up having maybe 2 beers and although enjoyable, I don’t feel that light switch turning on which encourages me to drink more. Can I force myself…

I started taking it in November and I’m down 30 pounds and my retina has detached 2x for no apparent reason since then. My drinking is unchanged, except I get full sooner and drink slower. Because of the discomfort.

Re: Ozempic drug supresses desire to smoke, drink and more?

#305

Post by pton_xd » Sat, May 20, 2023, 5:40 AM UTC

Aloha wrote: post #267

mrcrumb1 wrote: post #188

Earlier quoted context omitted.

I'm a person who has vacillated between being close to normal weight and obese. I think people who don't have problems controlling their diet tend to underestimate just how hard it can be to eat at a calorie deficit or even just maintenance when you've lost a large amount of weight. When I'm at my lowest weight I literally am thinking about food constantly and my maintenance calorie intake drops to about 1500-1800 ca…

It's really hard to explain to someone the agony of being hungry all the time - without experiencing it, they just cant understand.

> It's really hard to explain to someone the agony of being hungry all the time - without experiencing it, they just cant understand.

This can easily happen if you eat the wrong food and train your gut to prefer the wrong types of food.

And by "wrong food" I mean the typical American diet -- processed food and soda.

Re: Ozempic drug supresses desire to smoke, drink and more?

#306

Post by mgarfias » Sat, May 20, 2023, 5:41 AM UTC

desmosxxx wrote: post #174

mgarfias wrote: post #139

Earlier quoted context omitted.

I’ve been on it (at 1mg, then 2mg doses) for 3-4 years now. Worst side effect for me is the tendency to have sulfur smelling burps if I have any kind of stomach upset.

did the weight stay off? Do you notice tolerance

Didn’t lose weight at 1mg. Down about 20# since the 2mg was approved.

But, also doing CrossFit 3D/wk. and now have a CGM so I can easily track blood glucose.

Re: Ozempic drug supresses desire to smoke, drink and more?

#307

Post by vore » Sat, May 20, 2023, 5:44 AM UTC

andy_ppp wrote: post #287

vore wrote: post #276

Earlier quoted context omitted.

This is such a "one weird trick your doctor doesn't want you to know!" anecdote. Mounjaro and Ozempic are generally prescribed in instances where dietary interventions are insufficient and perhaps one of the last resorts before bariatric surgery. If your dietary interventions worked for you -- great! But there is only a certain class of people for which they work for, and it is rude to assume the OP hasn't tried thes…

The gold standard for diet is whatever people can maintain longer term!

That is of course more correct :) But the first step is building intuition about what and how you’re eating!

Re: Ozempic drug supresses desire to smoke, drink and more?

#308

Post by nmca » Sat, May 20, 2023, 5:45 AM UTC

randallsquared wrote: post #194

NickC25 wrote: post #30

[flagged]

> Sad that the obvious route (diet and exercise) is skipped by so many people It is definitely true that many people find it difficult to be abjectly miserable all the time. The difference with Ozempic/Wegovy is (and I know this is hard to believe!) you can eat a small portion of something and actually feel satisfied and literally just not want more. This is mind-blowing when you've never experienced it before. I've…

It is.

Re: Ozempic drug supresses desire to smoke, drink and more?

#309

Post by vore » Sat, May 20, 2023, 5:46 AM UTC

usernew wrote: post #299

vore wrote: post #276

Earlier quoted context omitted.

This is such a "one weird trick your doctor doesn't want you to know!" anecdote. Mounjaro and Ozempic are generally prescribed in instances where dietary interventions are insufficient and perhaps one of the last resorts before bariatric surgery. If your dietary interventions worked for you -- great! But there is only a certain class of people for which they work for, and it is rude to assume the OP hasn't tried thes…

and... this person now takes these last-measure pills forever? or here in the real world, do they use the pills to lose weight, and then maintain that normal weight forever with... perhaps a diet trick that works? people who have to take last-measure medication usually don't stop eating when they are full. i know, it's weird to tell someone who doesn't stop eating when they're full, how to still maintain weight if th…

Obesity is often a chronic medical condition that’s not solely controllable by willpower. There is no difference between taking pills for treating obesity as a chronic condition vs any other chronic condition, like type 1 diabetes. Decades of treating obesity as a personal failing have resulted in worse and unsustainable health outcomes.

And again, you are being far too presumptuous about OP’s interventions. And I certainly don’t know what this business about ADD appointments at the florist or grocery shopping at Jiffy Lube you’re talking about is.

Re: Ozempic drug supresses desire to smoke, drink and more?

#310

Post by htag » Sat, May 20, 2023, 5:47 AM UTC

mym1990 wrote: post #70

acjohnson55 wrote: post #29

Earlier quoted context omitted.

Most research indicates "yes", conditioned on the consensus of what comprises the modern lifestyle. I've been trying to understand what changed to create the obesity epidemic. Many things contribute, but it's hard to identify the smoking gun. My understanding is that one major lever seems to be the advent of snacks, refrigeration, and microwaves. Drastically reduced food prep overhead has radically alerted eating pat…

It seems pretty obvious that the massive injection of sugar in the 60s and 70s into diets paved the way for pretty much everything else that followed(snacks, fast food, convenient food, etc). I guess we can all ignore that diabetes is driven by insulin resistance and the body's inability to process glucose, which is conveniently also the predominant thing in our food today, because we would rather look the other way…

To pile on other popular theories on smoking guns, there is a widespread decrease in physical activity levels. Physical activity can delay or prevent type 2 diabetes, as well as having widespread benefits on almost every system of the body. Physical activity also improves mental health, which impacts some behaviors around emotional/addiction driven over eating.