Hacker News Board Hacker News, browsed like a classic message board
Live data from Hacker News

Ozempic drug supresses desire to smoke, drink and more?

theatlantic.com

Post reply on HN
Print view View original

171–180 of 504 posts

Re: Ozempic drug supresses desire to smoke, drink and more?

#171

Post by reaperman »

SamoyedFurFluff wrote: post #131

How long is the research info ozempic and other hormonal weight loss drugs? Remember the last miracle drug that went to the market for weight loss had to be retracted for killing people or damaging their hearts to the tune of over 10 billion dollars in damages paid out.

Drugs acting on GLP-1 (ozempic), GIP, and glucagon receptors are largely shown to help hearts and cardiovascular health specifically (and independently of weight loss). They also improve lipid profiles (HDL/LDL), and have a multitude of other benefits.

Whether they, for example, increase the rate of glial brain cancer ... they really haven't been out long enough to know.

Re: Ozempic drug supresses desire to smoke, drink and more?

#172

Post by lazyasciiart »

AtlasBarfed wrote: post #160
Retric wrote: post #145

Earlier quoted context omitted.

There’s huge tradeoffs people rarely talk about in Medicine. Significant risk of soiling yourself vs a statistically significant reduction in risk of early death isn’t a big deal for the FDA. In many cases the hell that is chemo is considered acceptable for even moderate increases in expected lifespan. That’s why people started talking healthy life expectancy vs just life expectancy.

Well duh, if you discuss the side effects with patients, they won't take the drug and the drug people won't send you hookers.

Bizarrely enough, the pressure doesn't always go in that direction.

Re: Ozempic drug supresses desire to smoke, drink and more?

#173

Post by [deleted] »

bluepizza wrote: post #141
iwanttocomment wrote: post #74

Earlier quoted context omitted.

I seriously doubt doctors are aggressively pushing eating well and exercising. Have you ever... been to a doctor when you've been obese? I assure you that they will indeed push eating well and exercising to obese people. Even when you've already been eating well and exercising. This will not be an intervention by the PCP themselves - your primary can really just refer people to substantial interventions - but they wi…

[flagged]

[deleted]

Re: Ozempic drug supresses desire to smoke, drink and more?

#174

Post by desmosxxx »

mgarfias wrote: post #139
cameronh90 wrote: post #119

Earlier quoted context omitted.

As a counterpoint, I've been using it for several months and have had no side effects to speak of other than occasionally some mild reflux. If anything, my energy levels actually went up immediately after starting it. Normally I was pretty sluggish but it felt like some extra firepower was unlocked. Everything has risks and benefits, and might harm some people. I hope your family member gets better soon.

I’ve been on it (at 1mg, then 2mg doses) for 3-4 years now. Worst side effect for me is the tendency to have sulfur smelling burps if I have any kind of stomach upset.

did the weight stay off? Do you notice tolerance

Re: Ozempic drug supresses desire to smoke, drink and more?

#175

Post by reaperman »

scheme271 wrote: post #21
BizarroLand wrote: post #10

Earlier quoted context omitted.

You can buy it as a "research chemical" and save money, but then the potential consequences of diy medicine and all that that entails are all on you. Hopefully the price will come down more as it becomes more prevalent or as generics become available.

GLP-1 agonists are a bit more tricky since they are temperature sensitive and need to be injected. You'll really need to be careful to keep it sterile and handle it properly. Whether the "research chemical" will receive the proper care until it gets into your hands is something that you're literally gambling your health on.

You ship it as a dry/lypohilized powder, both semaglutide and tirzepatide survives long China->Europe shipping in the summer just fine, with customs delays. The testing I've seen showed 99.965% purity of semaglutide after 22 days in shipping from China to Poland during April. Tirzepatide shows 99.064% purity after 58 days of shipping in October-November. These didn't start out at 100.00% purity either, so they likely experienced absolutely minimal degradation in shipment.

You reconstitute it with Bacteriostatic Water which is available without a prescription in the USA and contains 0.9% benzyl alcohol to inhibit bacterial growth.

If you're particularly concerned you buy a 0.22 micrometer PVDF "syringe filter" and pump it through that to another, fresh/sealed sterile vial which you can get for like $2.00 from a medical supply company (the syringe, filter, and vials are gamma-irradiated to destroy any remnants of RNA/DNA). That size filtration will filter out any lifeforms (fungal, bacterial, viral) while allowing the peptide/drug itself to pass through. So you get a guaranteed sterile solution out of the filter.

Re: Ozempic drug supresses desire to smoke, drink and more?

#176

Post by paulpauper »

jmpman wrote: post #151

I’ve been on Mounjaro since August. Down almost 60lbs, and it’s been a life changer. Have I had some gastrointestinal issues, sure, but expected. I feel great and my brain seems to be functioning as well as when I was in my 20’s. Now, when I go to the bar with friends, I end up having maybe 2 beers and although enjoyable, I don’t feel that light switch turning on which encourages me to drink more. Can I force myself…

Good job, nice to see it works on reducing alcohol consumption too. I do not need this drug but it's nice knowing the option exists it need be. It gives hope to others too.

Re: Ozempic drug supresses desire to smoke, drink and more?

#177

Post by 0zemp2c »

iwanttocomment wrote: post #72
mym1990 wrote: post #68

Earlier quoted context omitted.

I am not holding Ozempic to needing to be the cure for anything. My point is that people without diabetes are looking to this drug for weight loss, at which point they create a dangerous dependency, with no hard evidence that their actual health improves. This is opposed to coming up with long term solutions that involve re-evaluating daily decisions that lead to some of these diseases in the first place. If Ozempic…

Is it really a dangerous dependency ? There's been no evidence of anything happening once individuals go off of semaglutide or tirzepatide other than the tendency of gaining weight to the original levels and/or blood sugar readings returning to the pre-medication levels. This is the most common outcome anyone has trying literally any calorie-reducing diet, medication or not. There's no evidence that people are ending…

How dangerous is it to have a new $1k/month bill you need to pay forever?

So far there is no indication insurance companies are going to pay for 100 million Americans going on Ozempic who aren't diabetic...

Anecdotally, another danger is people confusing less eating with a healthy diet. I know someone on Ozempic...eats less but what is eaten is the same old junk...

Re: Ozempic drug supresses desire to smoke, drink and more?

#178

Post by Jun8 »

So, instead is suppressing the desire to eat, how about inventing a drug that blocks the absorption or breakdown of carbohydrates in the gut? Or maybe control the gut biome so that growth of bacteria that breaks down high calorie food is minimized.

Is this faster-than-light-like impossible daydream or is there any plausible path to it?

Re: Ozempic drug supresses desire to smoke, drink and more?

#179

Post by lazyasciiart »

bluepizza wrote: post #141
iwanttocomment wrote: post #74

Earlier quoted context omitted.

I seriously doubt doctors are aggressively pushing eating well and exercising. Have you ever... been to a doctor when you've been obese? I assure you that they will indeed push eating well and exercising to obese people. Even when you've already been eating well and exercising. This will not be an intervention by the PCP themselves - your primary can really just refer people to substantial interventions - but they wi…

[flagged]

Vacuously false. Do you think "eat well and exercise regularly" is some kind of magic switch? One day you are 120lbs overweight but then you eat well and exercise for a week and star in a film?

Re: Ozempic drug supresses desire to smoke, drink and more?

#180

Post by desmosxxx »

User23 wrote: post #104
ortusdux wrote: post #44

Earlier quoted context omitted.

>>due to the fact that eating now makes her sick. Reminds me of the first FDA approved weight loss drug, Alli, that basically just gastrointestinally punishes you if you eat more than a few grams of fat. https://en.wikipedia.org/wiki/Orlistat#Side_effects

My favorite fat loss drug along these lines is dinitrophenol. It is the true miracle fat burning drug. It interferes with cellular metabolism in such a way that the body just nonstop oxidizes fat. Fat mass loss in the order of a pound a day or more is entirely possible and some bodybuilders use it to get to a ludicrously low bodyfat percentage. Unfortunately oxidizing that much fat generates a lot of heat, so much th…

Also when you eat on it you are punished by heating up even more.
Post reply on HN