How long is the research info ozempic and other hormonal weight loss drugs? Remember the last miracle drug that went to the market for weight loss had to be retracted for killing people or damaging their hearts to the tune of over 10 billion dollars in damages paid out.
Ozempic drug supresses desire to smoke, drink and more?
131–140 of 504 posts
Re: Ozempic drug supresses desire to smoke, drink and more?
#132A drug that promotes weight loss, lessens the desire to smoke, drink, etc...sounds too good to be true? From what I have heard, all of these issues come back as soon as someone comes off the drug. So either a person is committing to a lifetime of being dependent on this drug, or a person is committing to some period of time of ideal living, followed by a possible time of depression after reverting to the status quo.
> A drug that promotes weight loss, lessens the desire to smoke, drink, etc...sounds too good to be true? It does sound too good to be true. However, it's possible that the drug is working on all of these through the same mechanism: by altering the brain's reward system. If that's true, the drug doesn't make you not want to eat, it makes you not want stuff , in general. That could potentially suppress a wide array of…
Reports from people using this don't indicate that they feel depressed at all. They either get a ton of nausea if their dose is too high, or they just don't get cravings to eat tons of "bad" food. Most people I've talked with on low doses report they can still eat large meals, but it has to be a pretty conscious, determined decision.
No one's been reporting depression that I've seen. And these groups ('fitness enthusiasts') experiment with enough other things that do cause depression that they're quite sensitive to changes in "well-being", "outlook on life", "mood", and "energy levels". It would be more widely reported in these circles if it did resemble depression.
Re: Ozempic drug supresses desire to smoke, drink and more?
#133Earlier quoted context omitted.
> The only intervention that does reliably work is bariatric surgery. My understanding is surgery only works reliably because failure to comply with life style changes post-op is easily fatal and ethical doctors only perform the operation after patients have demonstrated that ability. In all but the most extreme patients, about a fifth to a third of the target weight loss has to happen pre-op for doctors to even cons…
" failure to comply with life style changes post-op is easily fatal" My understanding is naive but I always thought it was no longer possible to fail to comply after this intervention?
No, you can seriously damage your stomach, which is now already severely scarred.
Re: Ozempic drug supresses desire to smoke, drink and more?
#134What happens when you reach your target weight with drugs like this? After having learned potentionally nothing about nutrition, exercise, and self-control, are you stuck on these meds for life out of fear of binge-eating back to your original weight? FWIW I'm on a hundred-pound roller coaster ride from 300lbs to 200lbs; currently ~215. I've learned a lot about discipline and sustainable habits along the way.
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Re: Ozempic drug supresses desire to smoke, drink and more?
#135Earlier quoted context omitted.
I don’t necessarily mean dangerous in the health aspect, although long term affects of these drugs are not know yet…I mean the dependency on needed the drug to keep a certain lifestyle, and then having an “oh shit” moment when you’re in a place that you can’t access it, whether that be traveling or the supply of it becomes scarce, or it gets banned, etc
That sounds like the lesser of two evils to me. Get healthier now and maybe sometime later lose access to the thing that helps you be healthier...or don't get healthier now? Yeah, there are other, orthogonal, choices but I don't think they're part of this particular decision matrix.
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Re: Ozempic drug supresses desire to smoke, drink and more?
#136I'm surprised Ozempic gets all the press. Supposedly Mounjaro is all that and more. The wonderful Paul Ford has the best writeup I've seen that discusses these more meta levels, the post-human implications of a drug we can genuinely widescalely reprogram ourselves with. Paul's so great. https://www.wired.com/story/new-drug-switched-off-appetite-m... https://news.ycombinator.com/item?id=34660232
Semaglutide gets all the press because it's a lot cheaper and actually available (barely available, but available). Tirzepatide is much more difficult to get access to, though IMO it should be the one that people default to if they're going to take this class of drug.
Semaglutide will probably have the most side effects because it only has one action (GLP-1 agonist). Tirzepatide has slightly lower side effects because it adds a dual action (GLP-1 agonist + GIP analogue) so it can act at a lower magnitude on the GLP-1 receptors to avoid strong side effects, while still having higher efficacy due to its additional, separate, GIP action.
LY3437943 looks even more promising, with fewer side effects. LY3437943 retains both the actions of Tirzepatide but adds a third action, glucagon receptor agonist. So it should be able to have higher efficacy at a lower equivalent dose than the other two (less action on GLP-1 and GIP mechanisms, fewer side effects).
Re: Ozempic drug supresses desire to smoke, drink and more?
#137Now if only it didn’t cost so damn much every month even under insurance =(
You can get these wholesale from China from "reputable" gray-market wholesalers who get the chemicals made at contract manufacturing facilities. BYO QA/QC though, as with all non-FDA drugs. That's the huge catch, and it sucks for consumers. Testing just for active ingredient is >$100 and takes about a month. Testing for proper buffering agents, harmful contaminants, microbial contamination, etc is essentially unavailable at all.
Semaglutide is very, very cheap in the gray market. It's somewhat less effective than Tirzepatide and has slightly more side effects if you ramp up the dosage too quickly.
If an annual amount is purchased on the gray market, this brings the monthly cost down to:
- Semaglutide: $10/month
- Tirzepatide: $60/month
- Liraglutide: $87/month
- LY3437943: I have not yet seen this available, but it looks like distributors are notifying manufacturers of latent demand and are working to build up a supply chain.
Note that in the USA, it is legal to import certain amounts of FDA-approved drugs if you have a prescription for them. However, just because something is the exact same chemical as an FDA-approved drug does not make it an FDA-approved drug. It must be manufactured in an FDA certified facility and be the same brand/manufacturer/packaging/labeling/etc as the approved drug.
e.g. importing generic Sildenafil/Viagra is legal if you can find the Teva(tm) brand generic sildenafil in, say, Mexico or Canada for a better price. But it must be the pills manufactured by Teva in the appropriate facility with NDC #0093-5342-56[0].
If you import generic sildenafil "Cenforce" from the (very legitimate but not FDA-approved) Indian pharmaceutical manufacturer "Centurion Laboratories"...
...that would still be potentially criminal smuggling. Even if the pills you import show via laboratory test that they precisely match your medical prescription, they are not "FDA approved" and therefore not legal to import.
A lot of people do though!
Re: Ozempic drug supresses desire to smoke, drink and more?
#138Earlier quoted context omitted.
Have we though? I seriously doubt doctors are aggressively pushing eating well and exercising. Has anyone ever received a workout plan from their doctor besides some generic PT exercises? Do they develop nutrition plans tailored to you? Do they track your progress? Do they have any incentive for you to actually get better? Do they require regular blood tests and include all the tests that might actually tell them som…
I seriously doubt doctors are aggressively pushing eating well and exercising. Have you ever... been to a doctor when you've been obese? I assure you that they will indeed push eating well and exercising to obese people. Even when you've already been eating well and exercising. This will not be an intervention by the PCP themselves - your primary can really just refer people to substantial interventions - but they wi…
Legally in some states some doctors are mandated to bring up weight loss to sufficiently fat patients. But also, fat loss isn’t covered by insurance generally unless it’s paired with an existing health condition. So fat people who don’t have health problems don’t get help to lose weight but get all the shame. :)
Re: Ozempic drug supresses desire to smoke, drink and more?
#139I’m glad people are enjoying Ozempic. My experience from seeing a family member on it, is I would not touch it if I were a 500-pound alcoholic smoking two packs of cigarettes a day. That’s an exaggeration since it probably outweighs the health issues there, but only slightly. The person I know taking Ozempic has only lost weight (35 lbs) due to the fact that eating now makes her sick. She has been sapped of all energ…
As a counterpoint, I've been using it for several months and have had no side effects to speak of other than occasionally some mild reflux. If anything, my energy levels actually went up immediately after starting it. Normally I was pretty sluggish but it felt like some extra firepower was unlocked. Everything has risks and benefits, and might harm some people. I hope your family member gets better soon.
I’ve been on it (at 1mg, then 2mg doses) for 3-4 years now. Worst side effect for me is the tendency to have sulfur smelling burps if I have any kind of stomach upset.
Re: Ozempic drug supresses desire to smoke, drink and more?
#140I’m glad people are enjoying Ozempic. My experience from seeing a family member on it, is I would not touch it if I were a 500-pound alcoholic smoking two packs of cigarettes a day. That’s an exaggeration since it probably outweighs the health issues there, but only slightly. The person I know taking Ozempic has only lost weight (35 lbs) due to the fact that eating now makes her sick. She has been sapped of all energ…
As a counter-counter-point I've read most (~90%) of the papers that come out of trials registered at http://clinicaltrials.gov/ for all GLP-1 agonists, including ones that haven't been approved. The vast, vast, vast majority of secondary outcomes, for things like
- blood pressure
- lipids (HDL, LDL)
- insulin sensitivity
- blood glucose
- strokes
- cardiovascular events + deaths
- myocardial infarctions
- hemoglobin A1C,
- revascularization,
- etc, etc, etc
are literally all affected positively (to the benefit of the imaginary "mean" patient) in bulk.
Note though, that doesn't mean 100% of patients are have positive results, just that each of these are, in bulk, positive across the tested subjects when averaged together. There's little in the data to suggest that cases like your family member aren't happening or couldn't happen.
There's also evidence that GLP-1 agonists increase the rate of glucose use in the brain, accelerating learning rates. (The brain accounts for 2% of body weight but up to 25% of glucose consumption, it really is fueled by glucose)
https://clinicaltrials.gov/ct2/show/NCT00256256?term=stroke&...