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Ozempic drug supresses desire to smoke, drink and more?
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Re: Ozempic drug supresses desire to smoke, drink and more?
#182So, instead is suppressing the desire to eat, how about inventing a drug that blocks the absorption or breakdown of carbohydrates in the gut? Or maybe control the gut biome so that growth of bacteria that breaks down high calorie food is minimized. Is this faster-than-light-like impossible daydream or is there any plausible path to it?
this is what gastric bypass tries to do. it bypasses part of the digestive process
Re: Ozempic drug supresses desire to smoke, drink and more?
#183I’m glad people are enjoying Ozempic. My experience from seeing a family member on it, is I would not touch it if I were a 500-pound alcoholic smoking two packs of cigarettes a day. That’s an exaggeration since it probably outweighs the health issues there, but only slightly. The person I know taking Ozempic has only lost weight (35 lbs) due to the fact that eating now makes her sick. She has been sapped of all energ…
My story / anecdata.
About 6 months ago there was a posting about Ozempic and I had said something to the effect that it wasn't worth it watching some of the side effects my wife had from it. And then I went to the doctor for a check-up and lo and behold I had diabetes. Asymptomatic, but an A1C of 11. My doctor re-ran the test because he didn't believe it and it doesn't run in my family. My cholesterol had also jumped and he said he was going to put me on a statin after the initial 3 months of adjusting to the diabetes medication.
My Dr. puts me on Ozempic and I grumble about it but with that test results I had, I knew I had to do something. Fast forward 3 months, I dropped 20 pounds, and every other measurement is back in the green, including my A1C. Now, I made some serious lifestyle changes and ate a diabetic diet (limiting carbs, the types of carbs, etc), and have been keeping up with being more active but my entire relationship with food has changed because of Ozempic. Before I had a near compulsion to eat more than I should. Now, I don't because one, I feel fuller quicker and two, I know I'll feel horrible for hours if I over-eat. It only took one of those events to never want to do that again. I can't really explain why but I also don't have as strong of a desire to eat foods that are bad for me. I really thought I'd battle the cravings more after going cold turkey from "bad" foods. I can't say why it is but it's true. Side note, going to the grocery story was really difficult at first....there is so much sugar in the American food supply.
Energy wise I will say that I did struggle with low energy initially as my body adapted to lower calorie intake but I also learned that when I found the right balance of protein/complex carbs for me that my energy levels came back up and I now feel better than ever.
My doctor was shocked. I've never seen him that animated when I came back in for the 3 month follow-up. I didn't need to add any additional medications and they're slowly adjusting me back towards a single medication.
Re: Ozempic drug supresses desire to smoke, drink and more?
#184A drug that promotes weight loss, lessens the desire to smoke, drink, etc...sounds too good to be true? From what I have heard, all of these issues come back as soon as someone comes off the drug. So either a person is committing to a lifetime of being dependent on this drug, or a person is committing to some period of time of ideal living, followed by a possible time of depression after reverting to the status quo.
>From what I have heard, all of these issues come back as soon as someone comes off the drug. So either a person is committing to a lifetime of being dependent on this drug, or a person is committing to some period of time of ideal living, followed by a possible time of depression after reverting to the status quo. This is true of every weight loss intervention: Weight Watchers, low-carb, keto, Whole 30, etc. Once pe…
Diets fail because ppl lose willpower. These new drugs in theory make this easier
Re: Ozempic drug supresses desire to smoke, drink and more?
#185I’ve been on Mounjaro since August. Down almost 60lbs, and it’s been a life changer. Have I had some gastrointestinal issues, sure, but expected. I feel great and my brain seems to be functioning as well as when I was in my 20’s. Now, when I go to the bar with friends, I end up having maybe 2 beers and although enjoyable, I don’t feel that light switch turning on which encourages me to drink more. Can I force myself…
the most surprising thing to me is how you’re describing normal behavior that I can relate to all my life, but the community of strugglers is so big that this is a whole testimonial people feel comfortable and exalted to share like thats not something I’m deriding its just news to me makes me wonder what this drug actually does, flush gut bacteria? just the right ones?
it's a GLP-1 agonist
Re: Ozempic drug supresses desire to smoke, drink and more?
#186Earlier quoted context omitted.
> The only intervention that does reliably work is bariatric surgery. My understanding is surgery only works reliably because failure to comply with life style changes post-op is easily fatal and ethical doctors only perform the operation after patients have demonstrated that ability. In all but the most extreme patients, about a fifth to a third of the target weight loss has to happen pre-op for doctors to even cons…
New addictions post bariatric surgery is fairly common. Gambling for instance [1] replaces food. [1] https://www.researchgate.net/publication/332884264_Gambling_...
best to read the study before commenting on it
In the addiction literature, the development of gambling dependence after bariatric surgery is limited. Mitchel et al. reported that 2 cases presented with post-operative gambling addiction in their 3-year screening study in 201 post-op case (5). In our case, the presence of genetic background may be a risk factor for the develop-ment of gambling
2 out of 200 cases is not that common and close to baseline level
Re: Ozempic drug supresses desire to smoke, drink and more?
#187I’m glad people are enjoying Ozempic. My experience from seeing a family member on it, is I would not touch it if I were a 500-pound alcoholic smoking two packs of cigarettes a day. That’s an exaggeration since it probably outweighs the health issues there, but only slightly. The person I know taking Ozempic has only lost weight (35 lbs) due to the fact that eating now makes her sick. She has been sapped of all energ…
Yeah, that's definitely always been my challenge with weight loss. I have zero problem with self control -- I can easily cut calories in half or less (e.g. 1000-1200 cal/day), but it's simply that my body suffers immensely. I lose all energy, can't concentrate on anything, and my immune system weakens so I start getting colds constantly. I'm sure I'd easily lose weight with Ozempic but I'd still be suffering health i…
Calories are not created equal. They are equal in physics sense, but your body is not a "bomb calorimeter" (device to measure caloric content of whatever). So maybe instead of cutting your calories in half, you cut less and replace carb calories with fat calories or protein calories.
Or maybe you can even cut to 1000-1200 by replacing your calorie source with something else. For some weird reason carrots with butter work very well for me and I love the taste :-)
Re: Ozempic drug supresses desire to smoke, drink and more?
#188Some people really love to moralize and cite anecdotes about Ozempic.
Moralizing about weight loss is upsetting, as someone whose thankfully considers themselves "naturally thin". It's 100% true the vast majority (including me) needs to put some discipline into eating and exercise: normal people can't just eat whatever they want whenever they feel hungry. But normal people don't get fat eating whole foods, working out, eating below their demographic's daily intake; and normal people do…
I'm a person who has vacillated between being close to normal weight and obese. I think people who don't have problems controlling their diet tend to underestimate just how hard it can be to eat at a calorie deficit or even just maintenance when you've lost a large amount of weight. When I'm at my lowest weight I literally am thinking about food constantly and my maintenance calorie intake drops to about 1500-1800 calories.
Re: Ozempic drug supresses desire to smoke, drink and more?
#189Earlier quoted context omitted.
Unfortunately, suggesting that people eat less and exercise more doesn’t seem to actually work that well. We’ve been trying that for decades and the obesity epidemic just keeps getting worse.
Probably because people aren't acting on it, or sticking with it long enough to actually see results. Especially in today's world when they can just take a pill and loose 10-15 pounds, nobody wants to do something they probably don't like doing (consistent exercise or healthy eating) as part of a short-term or long-term process. A lot of people, especially those in food deserts or without access to adequate nutrition…
Probably because people aren't acting on it, or sticking with it long enough to actually see results.
Like telling penguins they need to flap harder to fly. The literature on diets on abysmal. People lose some weight and regain it, probably as willpower runs out. Look at all these celebrity weight loss shows over the past 2 decades--almost every contestant regains the weight, and these are people who have a lot of money and access to top chefs, trainers, etc.
Re: Ozempic drug supresses desire to smoke, drink and more?
#190Earlier quoted context omitted.
the most surprising thing to me is how you’re describing normal behavior that I can relate to all my life, but the community of strugglers is so big that this is a whole testimonial people feel comfortable and exalted to share like thats not something I’m deriding its just news to me makes me wonder what this drug actually does, flush gut bacteria? just the right ones?
it's a GLP-1 agonist
Ozempic/Wegovy is a GLP-1 receptor agonist, but Mounjaro is a GLP-1 and GIP receptor agonist