Hacker News Board Hacker News, browsed like a classic message board
Live data from Hacker News

Transfusion of brain fluid from young mice improves memory in old mice

statnews.com

Post reply on HN
Print view View original

61–70 of 158 posts

Re: Transfusion of brain fluid from young mice improves memory in old mice

#61

Post by SemanticStrengh »

yalogin wrote: post #25

May be a stupid question but how confident are we that we understand memory in mice? Is memory as humans perceive it the same as what mice perceive it?

We do not understand memory of humans nor of mices nor of C.elegans. The question of the neural code is an unsolved problem with close to zero progress. However we don't need to, The regions and deficits in memory processing are highly preserved/correlated between mammals. They are many potent Nootropics for memory, such as Dihexa and prl, those are called hypermnesics. A classical one is choline, found in eggs and overlap with the nicotine impact on intelligence

Re: Transfusion of brain fluid from young mice improves memory in old mice

#62

Post by Karawebnetwork »

davesque wrote: post #44

These kinds of articles give me the creeps. As interesting as the science is, I imagine this also encourages a bunch of silicon valley millionaires and billionaires to essentially become vampires.

On the reverse side of the coin, I would love to be able to extend the life of my parents by giving them liquids that my body is able to replenish.

Re: Transfusion of brain fluid from young mice improves memory in old mice

#63

Post by SemanticStrengh »

beached_whale wrote: post #2

I wonder how long until this is a thing some people do; like the blood transfusions from younger/healthy people.

Btw we can significantly increase blood production via Epo. The question is wether blood from cows/pigs rejuvenate. It could get an industrial scale.

Re: Transfusion of brain fluid from young mice improves memory in old mice

#64

Post by SemanticStrengh »

ninesnines wrote: post #37
mwint wrote: post #14

Earlier quoted context omitted.

I'm curious, what is your favorite paper of all time (the specification of 'last five years' sounds like it's not this one?)

ah there are a lot of really nice old nature/science neuroscience articles that are really clear! papers were more simple and clear 20 years ago

The papers from the 90s are generally my favorites.

Re: Transfusion of brain fluid from young mice improves memory in old mice

#65

Post by SemanticStrengh »

mwint wrote: post #14
ninesnines wrote: post #5

this above article is kind of inflammatory, however, this paper is incredibly interesting. I read it this morning and the concept of changing CSF in order to have an increase in oligodendrocyte progenitor cell proliferation and differentiation is such a creative idea; a lot of the idea has focused on increasing flow in order to move waste, etc with csf. I think this concept that CSF is also acting as an important mec…

I'm curious, what is your favorite paper of all time (the specification of 'last five years' sounds like it's not this one?)

I don't have a favorite but one that stands out is the resuscitation of cryogenized hamsters https://royalsocietypublishing.org/doi/10.1098/rspb.1956.005...

Re: Transfusion of brain fluid from young mice improves memory in old mice

#66

Post by SemanticStrengh »

s1artibartfast wrote: post #47
ninesnines wrote: post #5

this above article is kind of inflammatory, however, this paper is incredibly interesting. I read it this morning and the concept of changing CSF in order to have an increase in oligodendrocyte progenitor cell proliferation and differentiation is such a creative idea; a lot of the idea has focused on increasing flow in order to move waste, etc with csf. I think this concept that CSF is also acting as an important mec…

Modifying CSF turnover is not particularly novel, but I do think it is generally overlooked. CSF production cycling is greatly reduced in the elderly and and there are a lot of connections to memory diseases such as alzheimers. A few medical device startups have attacked the problem with promising results. Unfortunately, VC and national funding orgs aren't particularly interested in device based solutions because pil…

I remember seeing a drug/substance that potentiated the glymphatic system filtration but I just can't find it again, it's been a year..

Re: Transfusion of brain fluid from young mice improves memory in old mice

#67

Post by meowface »

ahurmazda wrote: post #56

Death is the ultimate equalizer. We take solace in the fact that no matter how rich, brutal, tyrannical, comically-villainous one is, death will surely come for us all. The day old-gizzards figure out how to sip on young-people juice and live forever, we are truly screwed.

I think it's the exact opposite. The day being old is no longer a disease and a path to inevitable death will be one of the greatest things to ever happen to humanity, now and forever into the future. Especially if you can retain a youthful, healthy brain and body no matter how old you are.

An old tyrannical movie villain dies and a to-be old tyrannical movie villain is born. Billions of people shouldn't be sentenced to death just because the world might be a bit better off if a few people weren't immortal.

Re: Transfusion of brain fluid from young mice improves memory in old mice

#68

Post by SemanticStrengh »

vasco wrote: post #40
Llamamoe wrote: post #33

Earlier quoted context omitted.

Not quite the same, but there exists a nootrooic called Cerebrolysin which is made from enzymatically treated pig brain peptides, including all sorts of brain growth factors.

I wonder if taking something with brain growth factors makes you more or less likely to suffer from more serious consequences if you have brain trauma. ie Are you more or less likely to have a serious concussion after hitting your head.

I cannot answer your question but growth factors are extremely effective after a concussion/AVC/TBI/stroke. People and doctors are extremely uneducated and therefore people that have TBI will have high persistent damage. The truth is, most of the damage is generally not done during the trauma, but during the weeks/month following it.. And those damages can be for the most part prevented by taking protectors, which as I said, isn't done in practice because science bad

Re: Transfusion of brain fluid from young mice improves memory in old mice

#69

Post by davesque »

Karawebnetwork wrote: post #62
davesque wrote: post #44

These kinds of articles give me the creeps. As interesting as the science is, I imagine this also encourages a bunch of silicon valley millionaires and billionaires to essentially become vampires.

On the reverse side of the coin, I would love to be able to extend the life of my parents by giving them liquids that my body is able to replenish.

Very good counter point :).

Re: Transfusion of brain fluid from young mice improves memory in old mice

#70

Post by DoreenMichele »

pengaru wrote: post #21
api wrote: post #15

Earlier quoted context omitted.

Could it be this simple? Shit just builds up in the blood that the liver and kidneys and stuff are not 100% efficient at removing? So you just need to... get rid of it or dilute it? I mean that can't possibly be a full solution but could a major "win" on life span or at least health span be as simple as some kind of dialysis session? Could this also be a hidden mechanism involved in some of that hyperbaric oxygen cha…

My lay person assumption is it's more complicated than that, just knowing how the body is always conserving resources and adapting to changing conditions. I'd expect the body's natural mechanisms responsible for this to wind down operations the more you intervened on its behalf. It's obviously the right choice in the elderly/ill, but for a healthy young person maybe it's better to exercise/strengthen the body's natur…

Exercise and fasting are two known and proven ways to clean up the tissues of the body, yes.
Post reply on HN