Transfusion of brain fluid from young mice improves memory in old mice • Hacker News Board

Re: Transfusion of brain fluid from young mice improves memory in old mice

#41

Post by three_seagrass » Thu, May 12, 2022, 5:47 PM UTC

pengaru wrote: post #19

jasfi wrote: post #16

Earlier quoted context omitted.

So drinking more water would be enough?

This isn't my area of expertise at all. A personal experience that comes to mind is when my childhood cat developed kidney disease. She drank plenty of water, urinated excessively, and her blood still became toxic without regular (~daily) intervention in the form of adding saline to her blood intravenously. Like a light switch she'd resume normal life after the saline bag emptied into her blood, then slowly become il…

Was the cat checked for diabetes?

Excessively drinking water, excessive urination, and renal failure are all co-morbidities for cats. Either way, kudos for helping them.

Re: Transfusion of brain fluid from young mice improves memory in old mice

#42

Post by mcguire » Thu, May 12, 2022, 5:47 PM UTC

thebeardisred wrote: post #4

beached_whale wrote: post #2

I wonder how long until this is a thing some people do; like the blood transfusions from younger/healthy people.

Apparently you, rossdavidh, and I are all on the same wavelength. I was imagining Elon and Jeff keeping a stable with the equivalent of vampire "blood bags".

"We drink elixirs that we refine

From the juices of the dying"

Shriekback, Nemesis, 1985.

Re: Transfusion of brain fluid from young mice improves memory in old mice

#43

Post by zuminator » Thu, May 12, 2022, 5:49 PM UTC

beached_whale wrote: post #2

I wonder how long until this is a thing some people do; like the blood transfusions from younger/healthy people.

Better would be if there's a way to mass produce the fluid in a lab.

Re: Transfusion of brain fluid from young mice improves memory in old mice

#44

Post by davesque » Thu, May 12, 2022, 5:52 PM UTC

These kinds of articles give me the creeps. As interesting as the science is, I imagine this also encourages a bunch of silicon valley millionaires and billionaires to essentially become vampires.

Re: Transfusion of brain fluid from young mice improves memory in old mice

#45

Post by NegativeLatency » Thu, May 12, 2022, 5:54 PM UTC

davesque wrote: post #44

These kinds of articles give me the creeps. As interesting as the science is, I imagine this also encourages a bunch of silicon valley millionaires and billionaires to essentially become vampires.

Blood boy -> brain boy

Re: Transfusion of brain fluid from young mice improves memory in old mice

#46

Post by [deleted] » Thu, May 12, 2022, 5:56 PM UTC

api wrote: post #15

pengaru wrote: post #13

Haven't similar things been observed with blood transfusions of young blood into the elderly, which was then found to actually be unnecessary - even just diluting the blood with something neutral and clean produced similar results. "The solution to pollution is dilution"

Could it be this simple? Shit just builds up in the blood that the liver and kidneys and stuff are not 100% efficient at removing? So you just need to... get rid of it or dilute it? I mean that can't possibly be a full solution but could a major "win" on life span or at least health span be as simple as some kind of dialysis session? Could this also be a hidden mechanism involved in some of that hyperbaric oxygen cha…

[deleted]

Re: Transfusion of brain fluid from young mice improves memory in old mice

#47

Post by s1artibartfast » Thu, May 12, 2022, 5:57 PM UTC

ninesnines wrote: post #5

this above article is kind of inflammatory, however, this paper is incredibly interesting. I read it this morning and the concept of changing CSF in order to have an increase in oligodendrocyte progenitor cell proliferation and differentiation is such a creative idea; a lot of the idea has focused on increasing flow in order to move waste, etc with csf. I think this concept that CSF is also acting as an important mec…

Modifying CSF turnover is not particularly novel, but I do think it is generally overlooked. CSF production cycling is greatly reduced in the elderly and and there are a lot of connections to memory diseases such as alzheimers.

A few medical device startups have attacked the problem with promising results. Unfortunately, VC and national funding orgs aren't particularly interested in device based solutions because pills and injections are perpetually 5 years out.

I'm aware of at least one that was able to halt or reverse alzheimers in a 200 patient trial, but folded after they couldnt get funding to move forward.

Re: Transfusion of brain fluid from young mice improves memory in old mice

#48

Post by patbwill » Thu, May 12, 2022, 6:06 PM UTC

Seems a perfect movie plot: A villain kidnaps children to extract brain fluid looking for the immortality :-(

Re: Transfusion of brain fluid from young mice improves memory in old mice

#49

Post by bigodbiel » Thu, May 12, 2022, 6:08 PM UTC

Yay another hip SV startup just around the corner!

Re: Transfusion of brain fluid from young mice improves memory in old mice

#50

Post by bigodbiel » Thu, May 12, 2022, 6:11 PM UTC

patbwill wrote: post #48

Seems a perfect movie plot: A villain kidnaps children to extract brain fluid looking for the immortality :-(

Q Productions presents!

As conspiracy theory, it predates Trump/Qanon, we’ve had David Icke with his adrenochrome from children sucking reptilian royalties