Transfusion of brain fluid from young mice improves memory in old mice • Hacker News Board

Re: Transfusion of brain fluid from young mice improves memory in old mice

#21

Post by pengaru » Thu, May 12, 2022, 4:38 PM UTC

api wrote: post #15

pengaru wrote: post #13

Haven't similar things been observed with blood transfusions of young blood into the elderly, which was then found to actually be unnecessary - even just diluting the blood with something neutral and clean produced similar results. "The solution to pollution is dilution"

Could it be this simple? Shit just builds up in the blood that the liver and kidneys and stuff are not 100% efficient at removing? So you just need to... get rid of it or dilute it? I mean that can't possibly be a full solution but could a major "win" on life span or at least health span be as simple as some kind of dialysis session? Could this also be a hidden mechanism involved in some of that hyperbaric oxygen cha…

My lay person assumption is it's more complicated than that, just knowing how the body is always conserving resources and adapting to changing conditions. I'd expect the body's natural mechanisms responsible for this to wind down operations the more you intervened on its behalf.

It's obviously the right choice in the elderly/ill, but for a healthy young person maybe it's better to exercise/strengthen the body's natural abilities in these departments. I think one of the arguments for intermittent fasting is to clean up the detritus being kept around for energy sake, via natural mechanisms...

Re: Transfusion of brain fluid from young mice improves memory in old mice

#22

Post by candiddevmike » Thu, May 12, 2022, 4:41 PM UTC

pengaru wrote: post #13

Haven't similar things been observed with blood transfusions of young blood into the elderly, which was then found to actually be unnecessary - even just diluting the blood with something neutral and clean produced similar results. "The solution to pollution is dilution"

All the more reason to donate blood.

Re: Transfusion of brain fluid from young mice improves memory in old mice

#23

Post by bitwize » Thu, May 12, 2022, 4:46 PM UTC

beached_whale wrote: post #2

I wonder how long until this is a thing some people do; like the blood transfusions from younger/healthy people.

Gavin Belson is going to have a brain boy in his dotage.

Re: Transfusion of brain fluid from young mice improves memory in old mice

#24

Post by ClumsyPilot » Thu, May 12, 2022, 4:55 PM UTC

heavyset_go wrote: post #8

beached_whale wrote: post #2

I wonder how long until this is a thing some people do; like the blood transfusions from younger/healthy people.

It'll always creep me out that medical vampirism is a thing.

How long untill our billionairs people will be basically like aztec gods demanding human sacrafice for new organs

Re: Transfusion of brain fluid from young mice improves memory in old mice

#25

Post by yalogin » Thu, May 12, 2022, 4:55 PM UTC

May be a stupid question but how confident are we that we understand memory in mice? Is memory as humans perceive it the same as what mice perceive it?

Re: Transfusion of brain fluid from young mice improves memory in old mice

#26

Post by pphysch » Thu, May 12, 2022, 5:01 PM UTC

ClumsyPilot wrote: post #24

heavyset_go wrote: post #8

Earlier quoted context omitted.

It'll always creep me out that medical vampirism is a thing.

How long untill our billionairs people will be basically like aztec gods demanding human sacrafice for new organs

Yesterday

Re: Transfusion of brain fluid from young mice improves memory in old mice

#27

Post by samstave » Thu, May 12, 2022, 5:04 PM UTC

This is why I want a personal stem-cell account.

I would like an account of various bodily components, grown from my personal stem-cells, for injection / growth / use as I see fit.

My Stem Cells My Choice.

---

(for example, I want to regrow my eyeballs.)

Re: Transfusion of brain fluid from young mice improves memory in old mice

#28

Post by samstave » Thu, May 12, 2022, 5:06 PM UTC

sitkack wrote: post #20

pengaru wrote: post #19

Earlier quoted context omitted.

This isn't my area of expertise at all. A personal experience that comes to mind is when my childhood cat developed kidney disease. She drank plenty of water, urinated excessively, and her blood still became toxic without regular (~daily) intervention in the form of adding saline to her blood intravenously. Like a light switch she'd resume normal life after the saline bag emptied into her blood, then slowly become il…

You must have loved that cat very much.

No, he just had a lot of extra saline.

J/K

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I had a cat when I was in my 20s that got into a fight some eve...

Its face got infected and blew up. It was $8,000 for surgery, and I couldnt afford it - so had to put her down... but I did love that cat, and I would have paid it if I had it...

Re: Transfusion of brain fluid from young mice improves memory in old mice

#29

Post by JacobThreeThree » Thu, May 12, 2022, 5:06 PM UTC

pc86 wrote: post #9

thebeardisred wrote: post #4

Earlier quoted context omitted.

Apparently you, rossdavidh, and I are all on the same wavelength. I was imagining Elon and Jeff keeping a stable with the equivalent of vampire "blood bags".

I mean there's a Silicon Valley episode where Gavin has a "blood boy."

For the curious: https://www.youtube.com/watch?v=hBA0AH-LSbo

Re: Transfusion of brain fluid from young mice improves memory in old mice

#30

Post by a9h74j » Thu, May 12, 2022, 5:12 PM UTC

vmception wrote: post #7

Just don't do it to the Eldians. In all seriousness, I wonder if this can be synthesized. A transport layer for brain conductivity, just replace the fluid. Maybe create an even better fluid than what the young hosts have.

> just replace the fluid

Jiffy Brain franchises on the way.