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Transfusion of brain fluid from young mice improves memory in old mice

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31–40 of 158 posts

Re: Transfusion of brain fluid from young mice improves memory in old mice

#31
post #30

Just don't do it to the Eldians. In all seriousness, I wonder if this can be synthesized. A transport layer for brain conductivity, just replace the fluid. Maybe create an even better fluid than what the young hosts have.

> just replace the fluid Jiffy Brain franchises on the way.

Imagine the fraudulent upsells.

Re: Transfusion of brain fluid from young mice improves memory in old mice

#32
post #30

Earlier quoted context omitted.

> just replace the fluid Jiffy Brain franchises on the way.

Imagine the fraudulent upsells.

Your nasal filters are covered in a mucus, do you want us to replace them?

Re: Transfusion of brain fluid from young mice improves memory in old mice

#33

Just don't do it to the Eldians. In all seriousness, I wonder if this can be synthesized. A transport layer for brain conductivity, just replace the fluid. Maybe create an even better fluid than what the young hosts have.

Not quite the same, but there exists a nootrooic called Cerebrolysin which is made from enzymatically treated pig brain peptides, including all sorts of brain growth factors.

Re: Transfusion of brain fluid from young mice improves memory in old mice

#34
post #25

May be a stupid question but how confident are we that we understand memory in mice? Is memory as humans perceive it the same as what mice perceive it?

not a stupid question!

you can classify memory into many different components, and how memory in mice translates into humans is not extremely clear.

we can do experiments that do fear conditioning, or classic conditioning and operant conditioning, but the translation from mice to humans is definitely not clear cut. I think this is one of the biggest weaknesses of the paper actually

Re: Transfusion of brain fluid from young mice improves memory in old mice

#35
post #30

Earlier quoted context omitted.

> just replace the fluid Jiffy Brain franchises on the way.

Imagine the fraudulent upsells.

I hear you can go an extra 4,000 hours between changes with synthetics.

Re: Transfusion of brain fluid from young mice improves memory in old mice

#36
post #13

Haven't similar things been observed with blood transfusions of young blood into the elderly, which was then found to actually be unnecessary - even just diluting the blood with something neutral and clean produced similar results. "The solution to pollution is dilution"

same lab actually!

Re: Transfusion of brain fluid from young mice improves memory in old mice

#37
post #14

this above article is kind of inflammatory, however, this paper is incredibly interesting. I read it this morning and the concept of changing CSF in order to have an increase in oligodendrocyte progenitor cell proliferation and differentiation is such a creative idea; a lot of the idea has focused on increasing flow in order to move waste, etc with csf. I think this concept that CSF is also acting as an important mec…

I'm curious, what is your favorite paper of all time (the specification of 'last five years' sounds like it's not this one?)

ah there are a lot of really nice old nature/science neuroscience articles that are really clear! papers were more simple and clear 20 years ago

Re: Transfusion of brain fluid from young mice improves memory in old mice

#39
post #13

Haven't similar things been observed with blood transfusions of young blood into the elderly, which was then found to actually be unnecessary - even just diluting the blood with something neutral and clean produced similar results. "The solution to pollution is dilution"

All the more reason to donate blood.

Now I just need to figure out how to donate brain fluid...

Re: Transfusion of brain fluid from young mice improves memory in old mice

#40

Just don't do it to the Eldians. In all seriousness, I wonder if this can be synthesized. A transport layer for brain conductivity, just replace the fluid. Maybe create an even better fluid than what the young hosts have.

Not quite the same, but there exists a nootrooic called Cerebrolysin which is made from enzymatically treated pig brain peptides, including all sorts of brain growth factors.

I wonder if taking something with brain growth factors makes you more or less likely to suffer from more serious consequences if you have brain trauma. ie Are you more or less likely to have a serious concussion after hitting your head.
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