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First person receives Pfizer Covid-19 vaccine in UK

bbc.com

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Re: First person receives Pfizer Covid-19 vaccine in UK

#181

Post by monkeynotes »

refurb wrote: post #153
chimprich wrote: post #139

Earlier quoted context omitted.

> "Significant testing" is 20,000 people. We're preparing to roll it out to billions. That's not "significant testing". If there was a 1 in 500,000 side effect, you'd never see it in the trials. That is significant testing. It is correct that you might not see a 1 in 500,000 side-effect in testing, but a 1 in 500,000 adverse effect is probably a risk factor that most people could accept. > And yes, these vaccines are…

Statins were tested in tens of thousands and the treated population is probably 100x to 1000x. With the Covid vaccine we’re talking 10,000x expansion of patient population. And your body also uses neurotransmitters all the time but we don’t wave our hands and say antidepressants are ok because they just modify neurotransmitters. New technology means new "unknown unknowns". But with that said, I'm not saying don't get…

This whole pandemic has fued with our critical thinking. If you rewound to 2019 and had a story about a flu vaccine that had been rushed through we'd all be asking questions.

Just because there is a huge necessity to rush approval and dispersement doesn't mean the risks of unknown side effects are diminished. Lengthy approval processes and clinical trials are in place for a reason. And when you administer this vaccine to billions of people you are almost certain to see side effects. That's just simple science.

Re: First person receives Pfizer Covid-19 vaccine in UK

#182

Post by SlateBlate »

monkeynotes wrote: post #166
chimprich wrote: post #68

Earlier quoted context omitted.

There isn't any evidence for serious side-effects from mRNA vaccines. The vaccines have undergone significant testing, and they're not doing anything magical. If you're going to insinuate that the vaccines have significant risks, you should provide some evidence. (This bar should also be a bit higher in my opinion in the middle of a public health emergency.) Compare a statement like "5g has great potential, but I'm r…

What crazy logic is this? You are saying one needs to have evidence of risk in order to ask if there is any evidence of risk. What is wrong with people when simply asking about negative impacts of a rushed vaccine is considered a worthless distraction. I thought the audience of hacker news users would also be curious, inquisitive folk.

Yeah, I'm quite surprised too.

I've been lurking here for at least 10 years and consider this to be the best place to discuss everything openly. But this sensivity to question anything related to vaccine is beyond ridiculous. Even asking what the side effects are like OP did gets you downvoted.

And by the way, I will take the vaccine asap because of my health issues, but this doesn't mean we can't even ask questions about it.

Re: First person receives Pfizer Covid-19 vaccine in UK

#183

Post by fabian2k »

LatteLazy wrote: post #164
mikepechadotcom wrote: post #32

I feel like mRNA vaccines have huge potential, but I am really, really concerned about potential side effects. Does anyone know which other helper-substances are inside the vaccine, besides the RNA?

Ingredients list: >6. PHARMACEUTICAL PARTICULARS >6.1 List of excipients ALC-0315 = (4-hydroxybutyl) azanediyl)bis (hexane-6,1-diyl)bis(2-hexyldecanoate), ALC-0159 = 2-[(polyethylene glycol)-2000]-N,N-ditetradecylacetamide, 1,2-Distearoyl-sn-glycero-3-phosphocholine, cholesterol, potassium chloride, potassium dihydrogen phosphate, sodium chloride, disodium hydrogen phosphate dihydrate, sucrose, water for injections S…

The RNA isn't in that list. The first four are likely all components of the lipid vesicles that are used to deliver the mRNA. The rest of the list is mostly some salts and then sugar and water.

Re: First person receives Pfizer Covid-19 vaccine in UK

#184

Post by jfengel »

oxfordmale wrote: post #11
m1gu3l wrote: post #7

Earlier quoted context omitted.

not surprising. i am shocked people aren’t hawking fakes on the dark net yet.

I am sure my Junk email box is full with offers for private vaccination already

I just checked, and I didn't see any. The closest was an offer for KN95 masks. (Though this is GMail, which I think has started to just auto-delete a lot of the worst stuff. My spam folder now gets spams-per-day rather than kilospams-per-day.)

Re: First person receives Pfizer Covid-19 vaccine in UK

#185

Post by ghaff »

learc83 wrote: post #113
akmarinov wrote: post #25

Earlier quoted context omitted.

The US vaccination plan has vaccinating non-essential (read average) people starting at around May-June, so no way it happens in March. Doctors, the elderly and other more at risk groups will get it before that.

The US vaccination plan is state by state. In many states people working in food service and grocery stores, people under 60 who are overweight, have high blood pressure, asthma etc... will be offered the vaccine in phase 2. It’s not just doctors and the elderly, it’s a huge chunk of the population. And depending on how many people actually want the vaccine and how many are approved it’s possible that healthy, under…

It varies by state but I expect most will at least roughly follow CDC guidelines. There will probably be variance in who is considered essential and who gets it after essential works, at risk, and 65+. At least some places are looking to start vaccinate younger people who are more likely to spread and only then do other older age groups.

Re: First person receives Pfizer Covid-19 vaccine in UK

#186

Post by mynegation »

checker659 wrote: post #75
dbbk wrote: post #54

Earlier quoted context omitted.

There's not even any plans to offer vaccines privately in the UK yet. The NHS isn't going to offer it to travellers.

Not NHS, but what’s stopping private companies from purchasing from pfizer at 10x markup and selling to willing customers?

Some time in the future - maybe nothing. Right now - all current and future doses for many months (if not years) are accounted for in existing contracts. Selling the doses to private parties, especially at 10x markup would be a huge PR disaster and invitation to AGs to open investigations.

Re: First person receives Pfizer Covid-19 vaccine in UK

#187

Post by ghaff »

briefcomment wrote: post #173
einarfd wrote: post #127

Earlier quoted context omitted.

No vaccine is ever 100%, you will see that some vaccinated people do get sick. In addition you have people that can't be vaccinated, these are still at risk. But if you vaccinated enough people, the successful vaccinated will act as a kind of firewall and hinder the sickness from effectively spreading.

But comments above state that the vaccine doesn't effect spread. If that's true, then vaccinating everyone would not address any of those points.

It hasn't been proven to affect spread (because that wasn't tested for). But it's generally assumed it does to at least a degree.

Re: First person receives Pfizer Covid-19 vaccine in UK

#188

Post by thisistheend123 »

dm319 wrote: post #180

I work here and was in clinic this morning. We had three eligible patients. One consented to it and is having the vaccine now. The other two declined. Not making a point, just a data point.

Hey thanks for your comment.

Could you describe in more detail how the vaccines are currently being stored in your clinic?

How long does the vaccine can remain in room temperature, once taken out of clod storage.

How many doses have been allocated to your clinic and on an average how many patients do you foresee being vaccinated over a short period of time, let's say a month.

Also, are health workers also planning to get vaccinated soon, as they are on the frontline and among most vulnerable to infection.

Any other details you would like to share.

Thanks again.

Re: First person receives Pfizer Covid-19 vaccine in UK

#189

Post by dmurray »

hannob wrote: post #84
SlateBlate wrote: post #59

Earlier quoted context omitted.

Why is this comment getting downvoted? seems like a fair question. I've seen this now in several threads where even questioning side effects of the vaccine gets downvoted and looked down upon like they did something illegal. This is not HN I used to know.

There's a tendency to highlight risks and sideeffects of this vaccine that is without any basis. It's reasonable to ask what the risks are, but unspecific ramblings about risks aren't helpful and it's unreasonable to highlight very hypothetical risks compared to the very real risks of getting Covid-19. Right now the risk issue seems pretty clearcut: There were no serious sideeffects in the trials. What gave me additi…

> It seems almost impossible that the vaccines pose a greater risk than the risk of not using them.

While this is a reasonable conclusion from what we've read in the media, it's worth noting that this is at odds with the official opinions of the EMA and the FDA.

They both believe more data is needed, or that the agencies need more time to analyze the data, before they can decree that the benefits most likely outweigh the risks. Otherwise, they'd have approved the vaccines already.

Re: First person receives Pfizer Covid-19 vaccine in UK

#190

Post by vonmoltke »

Cthulhu_ wrote: post #168
timrichard wrote: post #149

Earlier quoted context omitted.

Seeing this post reminded me that when I had the 'flu vaccine a little while back, the Pharmacist advised avoiding Paracetamol (Tylenol?) afterwards in case it reduced the efficacy of the vaccine. A bit of quick Googling turned up study results from a while back suggesting this in relation to childhood vaccines. Just wondering if anyone here with experience in the field has a opinion on whether painkillers like these…

Honestly Tylenol is a really fucky one, I've had it once when I was in the US and it got me off my tits. I mean pardon my french but that stuff is something else. And in a lot of cases gratuitous; at best it takes the edge off, for me personally, some paracetamol has the same effect without the side effects of an inability to drive or operate heavy machinery.

I'm not sure what you took, but plain Tylenol is paracetamol (acetaminophen). It sounds like you may have taken a Tylenol-branded compound medication that added an antihistamine or something like that (there are several acetaminophen-plus over-the-counter medications available).
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