Earlier quoted context omitted.
But it's not actually AI, it's just programmable probability.
So is your brain. But it's not even yet programmable.
This is a simplistic, incorrect view of biology.
Progress of anti-aging therapies by clinical trial stage
111–120 of 151 posts
Re: Progress of anti-aging therapies by clinical trial stage
#112While I'm taking NMN, as it's proven to be safe, I know that HGH + DHEA is the only drug from the list that has already proven to make healthy people younger. I'm seriously considering it in a few years after it has more time to be proven safe enough. For now I'm planning to measure DNA methylation in my body to understand the reason for my chronic illnesses better. I already got my DNA sequenced, but now that methyl…
What's the difference between NMN vs NR? I take NR and they're chemically similar and I thought both are sold as anti-aging?
They are similar, David Sinclair prefers NMN, but he doesn't have that strong preference.
Re: Progress of anti-aging therapies by clinical trial stage
#113While I'm taking NMN, as it's proven to be safe, I know that HGH + DHEA is the only drug from the list that has already proven to make healthy people younger. I'm seriously considering it in a few years after it has more time to be proven safe enough. For now I'm planning to measure DNA methylation in my body to understand the reason for my chronic illnesses better. I already got my DNA sequenced, but now that methyl…
> I already got my DNA sequenced, but now that methylation can be measured cheaply as well, I don't see a reason why not to. Are they just quantifying how many methyl groups are attached to a piece of DNA? Methylation is a mechanism for site-specific in/activation, so I'm unclear (and curious) how this would be useful.
Methylation is changes slowly throughout the life, the strongest predictor of age inside the body (that's why it's used as an aging clock).
This also means that it may be the most important thing to learn to manipulate to defeat aging.
Also it's the cause of many non-genetic chronic diseases that come with age.
In summary it's a really really important thing to study.
https://en.wikipedia.org/wiki/Epigenetic_clock#Properties_of...
There are other hallmarks of aging though:
Re: Progress of anti-aging therapies by clinical trial stage
#114Quick summary of the meaning of Phases in medical trials: Phase 0: exploration of effectiveness Phase I: is the treatment safe? Phase II: does the treatment work? Phase III: is the treatment better than existing alternatives? Phase IV: After approval, monitor the long term effects of the treatment.
Phase I is more “what is the highest dose that can be given safely?”
Re: Progress of anti-aging therapies by clinical trial stage
#115Quick summary of the meaning of Phases in medical trials: Phase 0: exploration of effectiveness Phase I: is the treatment safe? Phase II: does the treatment work? Phase III: is the treatment better than existing alternatives? Phase IV: After approval, monitor the long term effects of the treatment.
More like:
Phase I: Will this treatment immediately kill people?
Phase II: Does this methodology seem like the right methodology to show some sort of result in larger trials?
Phase III: Does the treatment work better than some type of placebo for at least a few weeks without causing obvious and unjustifiable harms during those few weeks.
Phase IV: Let's shift our marketing budget into R&D so that we can claim to be unprofitable to congress.
Re: Progress of anti-aging therapies by clinical trial stage
#116See also: AgingBiotech.info
Specifically AgingBiotech.info/companies
(esp. the clinical stage & clinical trials columns).
Re: Progress of anti-aging therapies by clinical trial stage
#117Quick summary of the meaning of Phases in medical trials: Phase 0: exploration of effectiveness Phase I: is the treatment safe? Phase II: does the treatment work? Phase III: is the treatment better than existing alternatives? Phase IV: After approval, monitor the long term effects of the treatment.
More like: Phase I: Will this treatment immediately kill people? Phase II: Does this methodology seem like the right methodology to show some sort of result in larger trials? Phase III: Does the treatment work better than some type of placebo for at least a few weeks without causing obvious and unjustifiable harms during those few weeks. Phase IV: Let's shift our marketing budget into R&D so that we can claim to be u…
This is a super pessimistic and misleading description of phase 2 & 3 trials; actual efficacious drugs do come out of the FDA review process. Many phase 3 trials are against standard of care rather than placebo and many are longer than a few weeks, particularly for treatments where efficacy is hard to prove.
Re: Progress of anti-aging therapies by clinical trial stage
#118Re: Progress of anti-aging therapies by clinical trial stage
#119Earlier quoted context omitted.
> I know that HGH + DHEA is the only drug from the list that has already proven to make healthy people younger. If you have any ready-researched and outlined sources or links for this, please post them here for reference. I know that we all can google, but I think linking here will help a lot of people, me included. HN articles are sometimes used as an online notepad of sorts, a repository of well researched and comp…
My guess is he is referring to this paper, which made headlines a few months ago: https://onlinelibrary.wiley.com/doi/full/10.1111/acel.13028
...tested on 7 people.
Re: Progress of anti-aging therapies by clinical trial stage
#120There is a real possibility that in the next few decades some of these therapies might work. The book Lifespan by Dr David Sinclair is really interesting. Sinclair is a professor at Harvard. He's highly optimistic that something will come of the various ideas looking at slowing aging. https://www.amazon.com/Lifespan-Why-Age_and-Dont-Have/dp/150...
So when it happens, will we stop having kids? Because our current population and lifestyle do not seem sustainable. I only see population increasing and lifestyle being more burdensome on environment.