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Progress of anti-aging therapies by clinical trial stage

lifespan.io

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Re: Progress of anti-aging therapies by clinical trial stage

#31

Post by dannykwells »

1996 wrote: post #4
dannykwells wrote: post #2

Interesting but a bit confusing since most of these drugs are for other conditions, and are not seeking approval based on ability to slow/stop /reverse aging. Thus any approvals would require having a particular condition to get a prescription (or an unethical doctor), and this aren't immediately useful. Would be nice to be able to select only those drugs seeking broad spectrum approval based on specific aging biomar…

> any approvals would require having a particular condition to get a prescription (or an unethical doctor) Wrong on both counts. Let me introduce you to indian online pharmacies, where you can get mostly anything already. I get my eyedrops from less than the US deductible, delivered at my door. I have a prescription, but they didn't even check. Even better: some molecules are on any restricted list, and thus legal to…

Great, so the advice is, "Take a drug, compounded in a foreign country with different/more lax regulations, for some hypothesized, 100% unproved reason, without a doctor monitoring it."

Good luck.

Re: Progress of anti-aging therapies by clinical trial stage

#32

Post by apsec112 »

lawrenceyan wrote: post #20

Proper sleep, a complete diet, minimizing stress (I'm personally biased towards meditation), intermittent fasting, and vigorous cardiovascular exercise complemented by strength training will by far have the most impact in maximizing your natural lifespan. You shouldn't look at doing anything else until you've at minimum mastered all of the listed items above. Nothing else will have as much outsized impact.

What makes sense to do personally is very different from what makes sense to research as a medical device or drug candidate. If a therapy has a 10% chance of extending lifespan by ten years, it's marginal for any particular person (given the current evidence), but a great candidate for a clinical trial.

Re: Progress of anti-aging therapies by clinical trial stage

#33

Post by lawrenceyan »

Japhy_Ryder wrote: post #23
lawrenceyan wrote: post #20

Proper sleep, a complete diet, minimizing stress (I'm personally biased towards meditation), intermittent fasting, and vigorous cardiovascular exercise complemented by strength training will by far have the most impact in maximizing your natural lifespan. You shouldn't look at doing anything else until you've at minimum mastered all of the listed items above. Nothing else will have as much outsized impact.

A vegan/plant-based diet and now we're talking! I like this list a lot!

There's very little evidence that completely abstaining from meat (animal based protein) brings any meaningful advantages from the perspective of life span. In fact in general, it's far more difficult to build a complete diet eating vegan only. I of course do think there's a moral argument to a vegan lifestyle, and am a definitely a strong proponent on that end.

Personally, I think a vegetarian diet strikes a better balance that's also more sustainable in the long term, assuming that you also do care about maximizing life span as well.

Re: Progress of anti-aging therapies by clinical trial stage

#34

Post by jcadam »

lawrenceyan wrote: post #33
Japhy_Ryder wrote: post #23

Earlier quoted context omitted.

A vegan/plant-based diet and now we're talking! I like this list a lot!

There's very little evidence that completely abstaining from meat (animal based protein) brings any meaningful advantages from the perspective of life span. In fact in general, it's far more difficult to build a complete diet eating vegan only. I of course do think there's a moral argument to a vegan lifestyle, and am a definitely a strong proponent on that end. Personally, I think a vegetarian diet strikes a better…

I abstain from red meat, but I eat plenty of chicken and fish...

Re: Progress of anti-aging therapies by clinical trial stage

#36

Post by tempsy »

brooklyndude wrote: post #35

You will get old. You will die. Just face reality. This trying to always put off aging is hopeless. Utterly futile. Enjoy every day, don't waste a second. You will die. And you ain't ready for it. But Mother nature is.

this is a pretty naive approach to aging.

you can age gracefully or you can age terribly. there are many things entirely in your control that can shift you one way or the other.

there's dozens of studies that show very strong correlation between calorie restriction and longevity.

Re: Progress of anti-aging therapies by clinical trial stage

#37

Post by dharma1 »

The_rationalist wrote: post #24
ramraj07 wrote: post #16

Earlier quoted context omitted.

Many studies suggest it's easier to prevent ageing from the beginning rather than de-ageing old people :(

Where can I find more about this?

Aging is basically cumulative damage to your body and its' ability to repair itself, especially mitochondrial DNA

Re: Progress of anti-aging therapies by clinical trial stage

#38

Post by lawrenceyan »

apsec112 wrote: post #32
lawrenceyan wrote: post #20

Proper sleep, a complete diet, minimizing stress (I'm personally biased towards meditation), intermittent fasting, and vigorous cardiovascular exercise complemented by strength training will by far have the most impact in maximizing your natural lifespan. You shouldn't look at doing anything else until you've at minimum mastered all of the listed items above. Nothing else will have as much outsized impact.

What makes sense to do personally is very different from what makes sense to research as a medical device or drug candidate. If a therapy has a 10% chance of extending lifespan by ten years, it's marginal for any particular person (given the current evidence), but a great candidate for a clinical trial.

Oh, I don't disagree. There's the entire burgeoning field of nootropics from which you can pick and choose as many supplements / drugs as you could want to test. An interesting point you might find, is that the nootropics which often have the greatest effect are the ones that help to deal with one or more of the items listed above.

For example, looking at some of the most common "life-extending / anti-aging" supplements people use which might hold promise of clinical efficacy:

[melatonin] -> proper sleep (usually there's an underlying issue of anxiety, stress, bad posture, sleep apnea, etc. that's being supplemented here)

[an innumerable count of different micronutrients] -> complete diet (those that see the most benefits are people that have deficiencies in those areas whether due to poor diet or genetic mutations from birth that lower efficiency of production but perhaps aren't so noticeable that they result in life threatening effects)

[metformin] -> intermittent fasting (which really ends up being the process of autophagy that you want to occur)

Re: Progress of anti-aging therapies by clinical trial stage

#39

Post by pccole »

jcadam wrote: post #34
lawrenceyan wrote: post #33

Earlier quoted context omitted.

There's very little evidence that completely abstaining from meat (animal based protein) brings any meaningful advantages from the perspective of life span. In fact in general, it's far more difficult to build a complete diet eating vegan only. I of course do think there's a moral argument to a vegan lifestyle, and am a definitely a strong proponent on that end. Personally, I think a vegetarian diet strikes a better…

I abstain from red meat, but I eat plenty of chicken and fish...

red meat is a good source of heme iron and vitamin b12. I agree with my coworker, a little steak a few days every month is good for you.

Re: Progress of anti-aging therapies by clinical trial stage

#40

Post by xiphias2 »

While I'm taking NMN, as it's proven to be safe, I know that HGH + DHEA is the only drug from the list that has already proven to make healthy people younger.

I'm seriously considering it in a few years after it has more time to be proven safe enough.

For now I'm planning to measure DNA methylation in my body to understand the reason for my chronic illnesses better. I already got my DNA sequenced, but now that methylation can be measured cheaply as well, I don't see a reason why not to.

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