71–80 of 151 posts
Quick summary of the meaning of Phases in medical trials: Phase 0: exploration of effectiveness Phase I: is the treatment safe? Phase II: does the treatment work? Phase III: is the treatment better than existing alternatives? Phase IV: After approval, monitor the long term effects of the treatment.
While I'm taking NMN, as it's proven to be safe, I know that HGH + DHEA is the only drug from the list that has already proven to make healthy people younger. I'm seriously considering it in a few years after it has more time to be proven safe enough. For now I'm planning to measure DNA methylation in my body to understand the reason for my chronic illnesses better. I already got my DNA sequenced, but now that methyl…
Earlier quoted context omitted.
That sounds cheap compared to the cost of old-age healthcare. For comparison, Alzheimer’s care homes cost ~£1000/week in the UK.
A lot of preventative care just delays old-age care rather than avoiding it entirely. I remember a professor in law school saying that during the big tobacco trials, someone mentioned that people dying younger from smoking meant lower healthcare costs overall, because the major predictor of healthcare costs is age. Basically everyone dies, and the older you are when you die, the more expensive it will be. Obviously t…
While I'm taking NMN, as it's proven to be safe, I know that HGH + DHEA is the only drug from the list that has already proven to make healthy people younger. I'm seriously considering it in a few years after it has more time to be proven safe enough. For now I'm planning to measure DNA methylation in my body to understand the reason for my chronic illnesses better. I already got my DNA sequenced, but now that methyl…
Are they just quantifying how many methyl groups are attached to a piece of DNA? Methylation is a mechanism for site-specific in/activation, so I'm unclear (and curious) how this would be useful.
Earlier quoted context omitted.
A lot of preventative care just delays old-age care rather than avoiding it entirely. I remember a professor in law school saying that during the big tobacco trials, someone mentioned that people dying younger from smoking meant lower healthcare costs overall, because the major predictor of healthcare costs is age. Basically everyone dies, and the older you are when you die, the more expensive it will be. Obviously t…
dying early while straining the system tasked with treating your lung cancer and emphysema might not actually save more money
Quick summary of the meaning of Phases in medical trials: Phase 0: exploration of effectiveness Phase I: is the treatment safe? Phase II: does the treatment work? Phase III: is the treatment better than existing alternatives? Phase IV: After approval, monitor the long term effects of the treatment.
There is a real possibility that in the next few decades some of these therapies might work. The book Lifespan by Dr David Sinclair is really interesting. Sinclair is a professor at Harvard. He's highly optimistic that something will come of the various ideas looking at slowing aging. https://www.amazon.com/Lifespan-Why-Age_and-Dont-Have/dp/150...
Looks interesting, but how could I ever afford to buy ~12 designer drugs which I figure likely cost at least $1-2/day if they are effective? Cost per year is $4K- $8K? I'm guessing I'll wait 20 years until they are off patent?
Living longer with good health means significantly extending the most lucrative years of your life. Although it sounds trite, the cost should correctly be thought of as an investment. (Assuming they actually work. I'm skeptical.)
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This post is poorly researched or misguided relative to the topic at hand. We are discussing drugs(or other systemic measures or therapies) that make people younger. The only thing that you can manage to do if you do all those things you listed perfectly is to come close to your theoretical maximum lifespan that is already preset in your biology/genetics. What we are trying to do with these drugs is to increase that…
I'm sorry to disappoint you, drugs (defined by the simple macromolecules we know them to be today) can supplement your body in doing only what it is already capable of. Increasing lifespan more than that requires an entirely new paradigm or class of therapeutics. Like you said, we'll need entirely new biological/genetic technology to address the system-wide mutation and degradation of the body that inevitably occurs…
Lots of drugs do things that your body is not capable of, and many drugs augment the way your body works in a way that is not possible without an external compound.