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Progress of anti-aging therapies by clinical trial stage

lifespan.io

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Re: Progress of anti-aging therapies by clinical trial stage

#61

Post by Erlich_Bachman »

brooklyndude wrote: post #35

You will get old. You will die. Just face reality. This trying to always put off aging is hopeless. Utterly futile. Enjoy every day, don't waste a second. You will die. And you ain't ready for it. But Mother nature is.

You have misunderstood what this is about. Yes we all know that we will die. And yes we still think that if you can add 1 or 10 or 50 or whatever healthy years by using some simple to use technology - then that is very valuable to a lot of people, and is a very worthwhile scientific pursuit.

And no, it is not hopeless or futile. There are animals that live 300 years, what basic biology class did you miss in order for you to think that it would be futile to modify humans which are biological machines with genetic programming to make them live at least that long?

Re: Progress of anti-aging therapies by clinical trial stage

#62

Post by epicureanideal »

LinuxBender wrote: post #17
chrisco255 wrote: post #10

Earlier quoted context omitted.

Not all of these are new drugs. NMN, for example, is a supplement that you can buy now. It's a bit expensive but the price is dropping as it becomes more popular. Others mentioned include HGH, which has been around for decades. Only problem there is that it's a controlled substance so getting a prescription for anti-aging purposes may be difficult.

I am not saying there isn't a use case for HGH, but you can increase your own natural HGH production through intermittent fasting, l-glutamine, and cycling up/down a few other molecules. I learned this by mistake, from trying to repair damage to my gut. The weird side effect was quite a bit of muscle development and I don't even work out. On top of that, I dampen mtorc1 with Berberine, Sulforaphane, Myrosinase, Trans…

It would be great if someone out there could build a simple site to track cheap quality sources of NMN and the progress of price decline over time!

Re: Progress of anti-aging therapies by clinical trial stage

#63

Post by throwaway_tech »

rsync wrote: post #52
throwaway_tech wrote: post #46

Earlier quoted context omitted.

>Proper sleep, a complete diet, minimizing stress (I'm personally biased towards meditation), intermittent fasting, and vigorous cardiovascular exercise complemented by strength training Yes, but the problem is this is such a broad brush stroke. For example, most people who are chronically stressed will generally never be able to obtain relief. There is a common joke about abs being made in the kitchen not in the wei…

"In other words the goal is to trigger the body to begin consuming/recycling dead cells and other cellular waste; however, this typically isn't triggered by time restricted eating, but requires longer periods of fasting (usually kicking in around after 20-24 hours of fasting)." I can't comment on how long it takes to achieve autophagy - I am happy to stipulate that you are correct. However, digestion is a very all-en…

>However, digestion is a very all-encompassing, rigorous and expensive activity for your body. If we believe that there are more "cleanup" mechanisms than just autophagy, it's not much of a reach to suggest that we engage in extra digestion at the expense of these maintenance tasks.

Make no mistake I think there are potential benefits to IF fasting such as these. For most people yes it will let their digestive system rest and even potentially reduce the overall intake of calories. Again it is all potential though, obviously not everyone needs to do IF to restrict calories if that is their goal, and there are ways to consume calories while simultaneously not digesting solid foods (that are typically outside the accepted scope of IF or fasting).

My point is the reason IF became a phenomena so widely discussed and implemented (edit: for increasing life span/expectancy) is directly related to the Nobel Prize in 2016; however, that work is related to autogaphy and fasting, not IF and IF related benefits. Edit:

Re: Progress of anti-aging therapies by clinical trial stage

#64

Post by andy_ppp »

joncrane wrote: post #26
chrisco255 wrote: post #10

Earlier quoted context omitted.

Not all of these are new drugs. NMN, for example, is a supplement that you can buy now. It's a bit expensive but the price is dropping as it becomes more popular. Others mentioned include HGH, which has been around for decades. Only problem there is that it's a controlled substance so getting a prescription for anti-aging purposes may be difficult.

HGH is a wonder drug, but it's tricky. Not only for the expense factor, but like everything else, when you add exogenous hormones, your body stops producing them. So if you supplement with HGH for years or even months, your body stops making it and the ability to produce more may take a very long time to come back. It may never come back. Also, there are many types of tumors that have HGH receptors, and HGH has an ev…

Probably worth cycling it then but no one is sure of optimal schedules even for fasting, let alone this...

Re: Progress of anti-aging therapies by clinical trial stage

#65

Post by nikkwong »

Erlich_Bachman wrote: post #54
xiphias2 wrote: post #40

While I'm taking NMN, as it's proven to be safe, I know that HGH + DHEA is the only drug from the list that has already proven to make healthy people younger. I'm seriously considering it in a few years after it has more time to be proven safe enough. For now I'm planning to measure DNA methylation in my body to understand the reason for my chronic illnesses better. I already got my DNA sequenced, but now that methyl…

> I know that HGH + DHEA is the only drug from the list that has already proven to make healthy people younger. If you have any ready-researched and outlined sources or links for this, please post them here for reference. I know that we all can google, but I think linking here will help a lot of people, me included. HN articles are sometimes used as an online notepad of sorts, a repository of well researched and comp…

My guess is he is referring to this paper, which made headlines a few months ago:

https://onlinelibrary.wiley.com/doi/full/10.1111/acel.13028

Re: Progress of anti-aging therapies by clinical trial stage

#66

Post by [deleted] »

xiphias2 wrote: post #40

While I'm taking NMN, as it's proven to be safe, I know that HGH + DHEA is the only drug from the list that has already proven to make healthy people younger. I'm seriously considering it in a few years after it has more time to be proven safe enough. For now I'm planning to measure DNA methylation in my body to understand the reason for my chronic illnesses better. I already got my DNA sequenced, but now that methyl…

[deleted]

Re: Progress of anti-aging therapies by clinical trial stage

#67

Post by sien »

There is a real possibility that in the next few decades some of these therapies might work.

The book Lifespan by Dr David Sinclair is really interesting. Sinclair is a professor at Harvard. He's highly optimistic that something will come of the various ideas looking at slowing aging.

https://www.amazon.com/Lifespan-Why-Age_and-Dont-Have/dp/150...

Re: Progress of anti-aging therapies by clinical trial stage

#68

Post by lawrenceyan »

Erlich_Bachman wrote: post #56
lawrenceyan wrote: post #20

Proper sleep, a complete diet, minimizing stress (I'm personally biased towards meditation), intermittent fasting, and vigorous cardiovascular exercise complemented by strength training will by far have the most impact in maximizing your natural lifespan. You shouldn't look at doing anything else until you've at minimum mastered all of the listed items above. Nothing else will have as much outsized impact.

This post is poorly researched or misguided relative to the topic at hand. We are discussing drugs(or other systemic measures or therapies) that make people younger. The only thing that you can manage to do if you do all those things you listed perfectly is to come close to your theoretical maximum lifespan that is already preset in your biology/genetics. What we are trying to do with these drugs is to increase that…

I'm sorry to disappoint you, drugs (defined by the simple macromolecules we know them to be today) can supplement your body in doing only what it is already capable of.

Increasing lifespan more than that requires an entirely new paradigm or class of therapeutics. Like you said, we'll need entirely new biological/genetic technology to address the system-wide mutation and degradation of the body that inevitably occurs through the progression of time. That requires going into the realm of biotech/nanotechnology/etc. which as of now, we are still very far away from being able to produce. It will require many more years of basic research in a plethora of different fields before we can even begin to think about it in fact. Your best bet if you want to make it all the way to then is to follow the steps listed above.

Re: Progress of anti-aging therapies by clinical trial stage

#69

Post by waserwill »

xiphias2 wrote: post #40

While I'm taking NMN, as it's proven to be safe, I know that HGH + DHEA is the only drug from the list that has already proven to make healthy people younger. I'm seriously considering it in a few years after it has more time to be proven safe enough. For now I'm planning to measure DNA methylation in my body to understand the reason for my chronic illnesses better. I already got my DNA sequenced, but now that methyl…

Maybe you know this, but: Interpreting DNA methylation isn't straightforward. Since it's involved in gene regulation and cell differentiation, it's variable across cells. Due to regulatory networks, whether any particular methylated region is responsible for some outcome may also be unclear.

That being said, if you have reason to believe that the knowledge will help, or are just curious, feel free

Re: Progress of anti-aging therapies by clinical trial stage

#70

Post by reitzensteinm »

bhouston wrote: post #6

Looks interesting, but how could I ever afford to buy ~12 designer drugs which I figure likely cost at least $1-2/day if they are effective? Cost per year is $4K- $8K? I'm guessing I'll wait 20 years until they are off patent?

Living longer with good health means significantly extending the most lucrative years of your life. Although it sounds trite, the cost should correctly be thought of as an investment.

(Assuming they actually work. I'm skeptical.)

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