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Progress of anti-aging therapies by clinical trial stage

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Re: Progress of anti-aging therapies by clinical trial stage

#101

Post by dpatrick86 »

xiphias2 wrote: post #40

While I'm taking NMN, as it's proven to be safe, I know that HGH + DHEA is the only drug from the list that has already proven to make healthy people younger. I'm seriously considering it in a few years after it has more time to be proven safe enough. For now I'm planning to measure DNA methylation in my body to understand the reason for my chronic illnesses better. I already got my DNA sequenced, but now that methyl…

What makes you think NMN has been "proven to be safe?" That's a pretty strong standard to conform to. There's virtually no clinical work that's been done at all, for starters.

A lot of genuine promising research in animals, but you also have this animal cancer model that suggests at least a little caution... https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448588/

Re: Progress of anti-aging therapies by clinical trial stage

#102

Post by partingshots »

dnhz wrote: post #88
staticassertion wrote: post #80

Earlier quoted context omitted.

> drugs (defined by the simple macromolecules we know them to be today) can supplement your body in doing only what it is already capable of. Lots of drugs do things that your body is not capable of, and many drugs augment the way your body works in a way that is not possible without an external compound.

I tend to think of aging as an overall degradation of the system. For instance, there’s loss of hair cells in the ear that reduces hearing higher frequencies. There’s clouding of the eye lens as the proteins there aggregate. Long lived cells like neurons accumulate oxidation and probably die at some slow rate. I can’t quite see how drugs which modulate existing biochemical pathways can stop, let alone reverse the pro…

That’s a very good summarization of the problems we face in dealing with aging. No drug can fix the damage that is caused by it. We have very early therapies that try to jumpstart or uplift existing biological machinery like the various immunotherapies currently being targeted towards cancers, but that’s still just taking advantage of what is inherent to our bodies. Over time these processes inevitably begin to fail.

You have to engineer new machinery to replace/repair the failing processes for any chance at real longevity. The kind of things that will be capable of doing something like that will be extraordinarily complex, and to compare the drugs we have available today is akin to comparing an abacus to a modern supercomputer.

Re: Progress of anti-aging therapies by clinical trial stage

#103

Post by naasking »

crystaldev wrote: post #79
reitzensteinm wrote: post #70

Earlier quoted context omitted.

Living longer with good health means significantly extending the most lucrative years of your life. Although it sounds trite, the cost should correctly be thought of as an investment. (Assuming they actually work. I'm skeptical.)

Maybe it's that I'm mid-career and burnt out, but the idea of getting to be a draft animal for an extra decade is utterly unappealing.

Agreed, but keep in mind rejuvenation means it'd be a lot harder to get burnt out and easier to recover.

Re: Progress of anti-aging therapies by clinical trial stage

#104

Post by naasking »

lawrenceyan wrote: post #68
Erlich_Bachman wrote: post #56

Earlier quoted context omitted.

This post is poorly researched or misguided relative to the topic at hand. We are discussing drugs(or other systemic measures or therapies) that make people younger. The only thing that you can manage to do if you do all those things you listed perfectly is to come close to your theoretical maximum lifespan that is already preset in your biology/genetics. What we are trying to do with these drugs is to increase that…

I'm sorry to disappoint you, drugs (defined by the simple macromolecules we know them to be today) can supplement your body in doing only what it is already capable of. Increasing lifespan more than that requires an entirely new paradigm or class of therapeutics. Like you said, we'll need entirely new biological/genetic technology to address the system-wide mutation and degradation of the body that inevitably occurs…

> Increasing lifespan more than that requires an entirely new paradigm or class of therapeutics. Like you said, we'll need entirely new biological/genetic technology to address the system-wide mutation and degradation of the body that inevitably occurs through the progression of time.

That's exactly what the drugs being discussed in this thread purportedly do. For instance, NMN allegedly repairs epigenetic factors that repair DNA damage, but which degrade as we age.

Re: Progress of anti-aging therapies by clinical trial stage

#105

Post by naasking »

chillingeffect wrote: post #85
pccole wrote: post #39

Earlier quoted context omitted.

red meat is a good source of heme iron and vitamin b12. I agree with my coworker, a little steak a few days every month is good for you.

Heme iron is toxic. [0] B12 you can get from a pill. The same stuff they inject into beef. [1] So if you skip eating red meat, you can avoid the toxins from cooking, such as HCA and PAH [2], the exogenous cholesterol, atherosclerotic carnitine [3], hormones, etc. I think that's a better way to get B12. [0] https://www.sciencedirect.com/science/article/abs/pii/S03784... [1] http://eerainuh.com/supplementation-of-vitam…

> Heme iron is toxic. [0]

Everything is toxic in inappropriate doses.

Re: Progress of anti-aging therapies by clinical trial stage

#106

Post by naasking »

dnhz wrote: post #88
staticassertion wrote: post #80

Earlier quoted context omitted.

> drugs (defined by the simple macromolecules we know them to be today) can supplement your body in doing only what it is already capable of. Lots of drugs do things that your body is not capable of, and many drugs augment the way your body works in a way that is not possible without an external compound.

I tend to think of aging as an overall degradation of the system. For instance, there’s loss of hair cells in the ear that reduces hearing higher frequencies. There’s clouding of the eye lens as the proteins there aggregate. Long lived cells like neurons accumulate oxidation and probably die at some slow rate. I can’t quite see how drugs which modulate existing biochemical pathways can stop, let alone reverse the pro…

> I can’t quite see how drugs which modulate existing biochemical pathways can stop, let alone reverse the processes I’ve named.

I'm honestly mystified why this would be a mystery. Your cells have the blueprint to grow a whole new body, but clearly many of these pathways are dormant. Is it really so far fetched that a drug could reactivate some of these pathways?

Like, why is there a loss of hair in the ear when for the first few years of life, that hair grows instead of dies? There is even evidence that age reversal can and has been done:

https://onlinelibrary.wiley.com/doi/full/10.1111/acel.13028

https://www.sciencedirect.com/science/article/pii/S009286741...

Re: Progress of anti-aging therapies by clinical trial stage

#108

Post by so_tobeclear »

throwaway_tech wrote: post #46
lawrenceyan wrote: post #20

Proper sleep, a complete diet, minimizing stress (I'm personally biased towards meditation), intermittent fasting, and vigorous cardiovascular exercise complemented by strength training will by far have the most impact in maximizing your natural lifespan. You shouldn't look at doing anything else until you've at minimum mastered all of the listed items above. Nothing else will have as much outsized impact.

>Proper sleep, a complete diet, minimizing stress (I'm personally biased towards meditation), intermittent fasting, and vigorous cardiovascular exercise complemented by strength training Yes, but the problem is this is such a broad brush stroke. For example, most people who are chronically stressed will generally never be able to obtain relief. There is a common joke about abs being made in the kitchen not in the wei…

Agreed as to your finale, most people have a pop culture understanding of physiology, but remain vehemently opposed to certain ideas largely accepted by alternative health communities. (And the functions, for those of you still unclear, are many including balancing the blood pH and removing actual toxins from the body.) However, regarding fasting, one of the most recent studies (0. https://www.nejm.org/doi/full/10.1056/NEJMra1905136

Re: Progress of anti-aging therapies by clinical trial stage

#109

Post by erentz »

xiphias2 wrote: post #40

While I'm taking NMN, as it's proven to be safe, I know that HGH + DHEA is the only drug from the list that has already proven to make healthy people younger. I'm seriously considering it in a few years after it has more time to be proven safe enough. For now I'm planning to measure DNA methylation in my body to understand the reason for my chronic illnesses better. I already got my DNA sequenced, but now that methyl…

How does one go about measuring their methylation?

Re: Progress of anti-aging therapies by clinical trial stage

#110

Post by Medicalidiot »

xiphias2 wrote: post #40

While I'm taking NMN, as it's proven to be safe, I know that HGH + DHEA is the only drug from the list that has already proven to make healthy people younger. I'm seriously considering it in a few years after it has more time to be proven safe enough. For now I'm planning to measure DNA methylation in my body to understand the reason for my chronic illnesses better. I already got my DNA sequenced, but now that methyl…

I’m going to give the strong recommendation of NOT supplementing HGH ever unless your physician advises it. HGH is a potential trigger for cancer, onto of how it is a potent anabolic hormone that will enlarge all your organs. Unless you have certain medical conditions, there is very little reason for one needing HGH.
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