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Progress of anti-aging therapies by clinical trial stage

lifespan.io

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Re: Progress of anti-aging therapies by clinical trial stage

#81

Post by Wohlf »

lucb1e wrote: post #77
herodotus wrote: post #29

Quick summary of the meaning of Phases in medical trials: Phase 0: exploration of effectiveness Phase I: is the treatment safe? Phase II: does the treatment work? Phase III: is the treatment better than existing alternatives? Phase IV: After approval, monitor the long term effects of the treatment.

Just to be clear, which of these phases is the "clinical trials" stage? Are all of them clinical trails and we're starting at zero now? (Not that Roman numerals have zero, by the way :).) The dictionary says clinical trials are about "safety and effectiveness" so I guess that is indeed early phases?

I may be wrong, but I think they are all different forms of clinical trials.

Re: Progress of anti-aging therapies by clinical trial stage

#83

Post by herodotus »

lucb1e wrote: post #77
herodotus wrote: post #29

Quick summary of the meaning of Phases in medical trials: Phase 0: exploration of effectiveness Phase I: is the treatment safe? Phase II: does the treatment work? Phase III: is the treatment better than existing alternatives? Phase IV: After approval, monitor the long term effects of the treatment.

Just to be clear, which of these phases is the "clinical trials" stage? Are all of them clinical trails and we're starting at zero now? (Not that Roman numerals have zero, by the way :).) The dictionary says clinical trials are about "safety and effectiveness" so I guess that is indeed early phases?

NIH Definition of a Clinical Trial:

"A research study in which one or more human subjects are prospectively assigned to one or more interventions (which may include placebo or other control) to evaluate the effects of those interventions on health-related biomedical or behavioral outcomes."

A phase 1 clinical trial is used to determine safety (including dosage) and involves far fewer people than a stage III clinical trial.

For Biotech startups, the companies value usually increases with each successfully completed trial. Conversely, the cost of conducting a trail also increases at each stage.

Re: Progress of anti-aging therapies by clinical trial stage

#84

Post by ganeshkrishnan »

mambojumbo wrote: post #78
sien wrote: post #67

There is a real possibility that in the next few decades some of these therapies might work. The book Lifespan by Dr David Sinclair is really interesting. Sinclair is a professor at Harvard. He's highly optimistic that something will come of the various ideas looking at slowing aging. https://www.amazon.com/Lifespan-Why-Age_and-Dont-Have/dp/150...

One can only hope that it wont be yet another hyper inflated bubble like ai is now.

Ai is hardly hyper inflated. Everything from your phone to cars to planes use ai and machine learning one way or the other.

Re: Progress of anti-aging therapies by clinical trial stage

#85

Post by chillingeffect »

pccole wrote: post #39
jcadam wrote: post #34

Earlier quoted context omitted.

I abstain from red meat, but I eat plenty of chicken and fish...

red meat is a good source of heme iron and vitamin b12. I agree with my coworker, a little steak a few days every month is good for you.

Heme iron is toxic. [0]

B12 you can get from a pill. The same stuff they inject into beef. [1]

So if you skip eating red meat, you can avoid the toxins from cooking, such as HCA and PAH [2], the exogenous cholesterol, atherosclerotic carnitine [3], hormones, etc. I think that's a better way to get B12.

[0] https://www.sciencedirect.com/science/article/abs/pii/S03784...

[1] http://eerainuh.com/supplementation-of-vitamin-b12-in-cattle...

[2] https://www.cancer.gov/about-cancer/causes-prevention/risk/d...

[3] https://www.prevention.com/food-nutrition/healthy-eating/a20...

Re: Progress of anti-aging therapies by clinical trial stage

#86

Post by Rallerbabs »

sien wrote: post #67

There is a real possibility that in the next few decades some of these therapies might work. The book Lifespan by Dr David Sinclair is really interesting. Sinclair is a professor at Harvard. He's highly optimistic that something will come of the various ideas looking at slowing aging. https://www.amazon.com/Lifespan-Why-Age_and-Dont-Have/dp/150...

There's a real possibility that some of those therapies might work in the next 6.5 years, as per Greg Bailey @ Juvenescence.

https://www.forbes.com/sites/robinseatonjefferson/2019/08/26...

Re: Progress of anti-aging therapies by clinical trial stage

#87

Post by lcnmrn »

ganeshkrishnan wrote: post #84
mambojumbo wrote: post #78

Earlier quoted context omitted.

One can only hope that it wont be yet another hyper inflated bubble like ai is now.

Ai is hardly hyper inflated. Everything from your phone to cars to planes use ai and machine learning one way or the other.

But it's not actually AI, it's just programmable probability.

Re: Progress of anti-aging therapies by clinical trial stage

#88

Post by dnhz »

staticassertion wrote: post #80
lawrenceyan wrote: post #68

Earlier quoted context omitted.

I'm sorry to disappoint you, drugs (defined by the simple macromolecules we know them to be today) can supplement your body in doing only what it is already capable of. Increasing lifespan more than that requires an entirely new paradigm or class of therapeutics. Like you said, we'll need entirely new biological/genetic technology to address the system-wide mutation and degradation of the body that inevitably occurs…

> drugs (defined by the simple macromolecules we know them to be today) can supplement your body in doing only what it is already capable of. Lots of drugs do things that your body is not capable of, and many drugs augment the way your body works in a way that is not possible without an external compound.

I tend to think of aging as an overall degradation of the system. For instance, there’s loss of hair cells in the ear that reduces hearing higher frequencies. There’s clouding of the eye lens as the proteins there aggregate. Long lived cells like neurons accumulate oxidation and probably die at some slow rate.

I can’t quite see how drugs which modulate existing biochemical pathways can stop, let alone reverse the processes I’ve named.

Re: Progress of anti-aging therapies by clinical trial stage

#89

Post by wrinkl3 »

lcnmrn wrote: post #87
ganeshkrishnan wrote: post #84

Earlier quoted context omitted.

Ai is hardly hyper inflated. Everything from your phone to cars to planes use ai and machine learning one way or the other.

But it's not actually AI, it's just programmable probability.

Which is what modern AI is - neat linear algebra that can perform certain tasks that are commonly associated with human cognition.

Re: Progress of anti-aging therapies by clinical trial stage

#90

Post by jonplackett »

Erlich_Bachman wrote: post #54
xiphias2 wrote: post #40

While I'm taking NMN, as it's proven to be safe, I know that HGH + DHEA is the only drug from the list that has already proven to make healthy people younger. I'm seriously considering it in a few years after it has more time to be proven safe enough. For now I'm planning to measure DNA methylation in my body to understand the reason for my chronic illnesses better. I already got my DNA sequenced, but now that methyl…

> I know that HGH + DHEA is the only drug from the list that has already proven to make healthy people younger. If you have any ready-researched and outlined sources or links for this, please post them here for reference. I know that we all can google, but I think linking here will help a lot of people, me included. HN articles are sometimes used as an online notepad of sorts, a repository of well researched and comp…

Is HGH + DHEA available to buy like a supplement? I would have presumed something containing hormones would be more regulated?
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