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Sounds like the industry responding with "we cant really know guys, right?" I'm throwing away my Advil right now. Screw that.
OTOH acetaminophen is known to be toxic; is there an alternative here for non narcotic inflammation, fever, and pain relief that is shown NOT to have tradeoffs for use?
> Our data demonstrate that ibuprofen alters the endocrine system via selective transcriptional repression in the human testes, thereby inducing compensated hypogonadism. Interesting. I’m no doctor, but this sounds like a not-super-transient effect. Amazing and slightly horrifying that they were able to measure this after a relatively short period of high-moderate sustained use.
When there's money to be made, dangerous side effects don't matter to them.
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>Ibuprofen is anti-inflammatory medication. And an acetaminophen tablet is a painkiller. While your statement is in fact true, ibuprofen is still a better choice for a fever. The latter is also generally considered a safer alternative, especially in long-term use — even though alternating the two would be ideal.
Acetaminophen is actually a pretty dangerous drug that is pretty easy to overdose on. It’s been said if it were discovered today it would be a prescription drug. On top of that numerous recent studies have shown many potential problems. https://www.webmd.com/drug-medication/news/20150302/does-lon... > Heavy use of acetaminophen is associated with kidney disease and bleeding in the digestive tract, the paper reports.…
This is terrifying. I used to take a lot of ibuprofen for frequent headaches (much better now). Military doctors were overzealous with the 800mg prescriptions (double the OTC dose). I suppose I should just use naproxen or acetaminophen? Ibuprofen always seemed the most effective to me.
I've been suffering from migraines since ~14yo, to the point that I can wake up and know if I'm going to get a migraine or not. I take naproxen, if I know I'll get a migraine I'll take 1x250mg, if I have a migraine I take 2-3x250mg depending on how severe it is. Cause of mine is generally lack of sleep when stressed so I make sure to sleep properly and don't let myself get stressed out, so I only get migraines ~once…
That sounds strikingly familiar. Is it my eyes? My sinuses? Allergies? My pillow? For 15 years and countless doctors nobody could figure it out. Then I went to the dentist and had my bite corrected and have not had a migraine since. I believe my bad bite was causing me to clench my jaw in my sleep.
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>I wonder what I should give my kids when they have fevers though You don't have to give them anything. Ibuprofen doesn't make the underlying infection causing the fever go away any quicker, it just alleviates the symptoms. It's a trade off between reducing short-term suffering and risking long-term defects. Personally my parents never gave me painkillers for fever and I'm grateful for it: fever pain is just a tempor…
Rapid rise in temperature in infants, toddlers, and young children can cause febrile seizure. Given the trade-offs, we generally choose to medicate our child when his temperature passes ~102 and it's on a rapid uptrend.
Just had a kidney stone problem—first for me, quite painful experience. My ibuprofen dosage is 800mg every 8 hours, as needed. I had little choice. “Sustained” is the keyword of the study here. On another note, maybe this will drive alternative treatments such as CBD/marijuana for those who need to sustain their pain relief.
> Our data demonstrate that ibuprofen alters the endocrine system via selective transcriptional repression in the human testes, thereby inducing compensated hypogonadism. Interesting. I’m no doctor, but this sounds like a not-super-transient effect. Amazing and slightly horrifying that they were able to measure this after a relatively short period of high-moderate sustained use.
I have to wonder how long the drug industry knew about this, but just brushed it under the rug like they do with all of their drugs, just to get them approved. When there's money to be made, dangerous side effects don't matter to them.
Ibuprofen (And Naproxen, etc...) is one of the most common drugs all around the world. I think most people I know have taken them at least once in their lifetimes.
It's just all too weird. Is this all a malignant cover up by the industry? Don't know what to say, especially considering this was released 1 year ago and afaik no more research has been conducted on this.
"Ibuprofen and hypogonadism — bench to bedside to misinterpreted hype?" at https://www.nature.com/articles/nrurol.2018.26 : > A recent study suggests modulation of luteinizing hormone signalling within the hypothalamic–pituitary–gonadal axis and downstream transcriptional effects caused by sustained ibuprofen use. However, this study cannot be used to draw any clinical conclusions regarding effects of ibuprofen on ma…
In curious how can they make a statement such as “the study cannot be used to draw any conclusions” without providing any kind of reasoning, and get published in Nature?
The rebuttal was also not published in Nature, but it was closer, published in Nature Reviews Urology.
I think the main basis for the criticism is that they didn't look at clinical outcomes like infertility or ability to conceive. As a result, we only have a (very robust) report of a relationship between ibuprofen and hormone levels, not between ibuprofen and x, where x is some directly important/meaningful clinical outcome.
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I have to wonder how long the drug industry knew about this, but just brushed it under the rug like they do with all of their drugs, just to get them approved. When there's money to be made, dangerous side effects don't matter to them.
I also wonder why for example the Chinese or heck the Cubans didn't discover this before, who have less of a corporate interest. Ibuprofen (And Naproxen, etc...) is one of the most common drugs all around the world. I think most people I know have taken them at least once in their lifetimes. It's just all too weird. Is this all a malignant cover up by the industry? Don't know what to say, especially considering this…