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Ibuprofen alters human testicular physiology to produce compensated hypogonadism

ncbi.nlm.nih.gov

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Re: Ibuprofen alters human testicular physiology to produce compensated hypogonadism

#11

Post by philliphaydon »

azhenley wrote: post #4

This is terrifying. I used to take a lot of ibuprofen for frequent headaches (much better now). Military doctors were overzealous with the 800mg prescriptions (double the OTC dose). I suppose I should just use naproxen or acetaminophen? Ibuprofen always seemed the most effective to me.

I've been suffering from migraines since ~14yo, to the point that I can wake up and know if I'm going to get a migraine or not.

I take naproxen, if I know I'll get a migraine I'll take 1x250mg, if I have a migraine I take 2-3x250mg depending on how severe it is.

Cause of mine is generally lack of sleep when stressed so I make sure to sleep properly and don't let myself get stressed out, so I only get migraines ~once a month now, compared to several times a week when I was at school.

Re: Ibuprofen alters human testicular physiology to produce compensated hypogonadism

#12

Post by eigenvector »

Alex3917 wrote: post #5

600mg per day is an enormous dose, albeit not especially uncommon. I’d be more interested though in the effects of, say, 200 - 400mg per week.

I recently went to the doctor with a shoulder strain and without even looking at it he prescribed 1000mg daily for 2 weeks then "come back if it still hurts".

Re: Ibuprofen alters human testicular physiology to produce compensated hypogonadism

#14

Post by couradical »

Alex3917 wrote: post #5

600mg per day is an enormous dose, albeit not especially uncommon. I’d be more interested though in the effects of, say, 200 - 400mg per week.

How is that an enormous dose? The recommendation is 2x200mg every 4-6h. When doing competitive athletics, I probably took 1-3g of “vitamin I” a day.

600mg a day is barely above a single dose.

Re: Ibuprofen alters human testicular physiology to produce compensated hypogonadism

#15

Post by lelandgaunt »

wmccullough wrote: post #7

As someone who is XXY, I can’t help but wonder what, if any issues would be caused by a pregnant mother taking a lot of this.

Long term acetaminophen usage is linked to a reduction in empathy.[0]

[0]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015806/

Re: Ibuprofen alters human testicular physiology to produce compensated hypogonadism

#17

Post by [deleted] »

azhenley wrote: post #4

This is terrifying. I used to take a lot of ibuprofen for frequent headaches (much better now). Military doctors were overzealous with the 800mg prescriptions (double the OTC dose). I suppose I should just use naproxen or acetaminophen? Ibuprofen always seemed the most effective to me.

[deleted]

Re: Ibuprofen alters human testicular physiology to produce compensated hypogonadism

#18

Post by ojm »

wmccullough wrote: post #7

As someone who is XXY, I can’t help but wonder what, if any issues would be caused by a pregnant mother taking a lot of this.

In Australia , pregnant women are told not to take ibuprofen unless told by doctor. Paracetamol Is the pain killer suggested, and only if really required.

Re: Ibuprofen alters human testicular physiology to produce compensated hypogonadism

#20

Post by Alex3917 »

azhenley wrote: post #10
Alex3917 wrote: post #5

600mg per day is an enormous dose, albeit not especially uncommon. I’d be more interested though in the effects of, say, 200 - 400mg per week.

It isn’t enormous at all. 400mg every 4 hours is the OTC dose (at least in the US). My prescription was 800mg.

> My prescription was 800mg.

Sure, but it’s not like 800mg is 4x or even 2x more effective than 200mg. Ibuprofen is great, I just don’t really see the point of risking dying and whatever else for what’s at most a very marginal benefit.

It’s not enormous in the sense that it’s uncommon per se, but rather in the sense that it’s way outside the efficient frontier on the risk/reward curve.

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