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Ibuprofen alters human testicular physiology to produce compensated hypogonadism

ncbi.nlm.nih.gov

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Re: Ibuprofen alters human testicular physiology to produce compensated hypogonadism

#151
post #71

Earlier quoted context omitted.

OTOH acetaminophen is known to be toxic; is there an alternative here for non narcotic inflammation, fever, and pain relief that is shown NOT to have tradeoffs for use?

Kratom / Cannabis oh wait these are illegal so big pharma can milk their poisons.

As soon as they're legal enough, they'll be milked too. I mean, you know, analogs tweaked for higher potency, etc.

Re: Ibuprofen alters human testicular physiology to produce compensated hypogonadism

#152
post #8

Earlier quoted context omitted.

Did the effect go away when they stopped the treatment? I can’t read it at the moment due to slow WiFi.

What was the effect in the first place?

Hypogonadism. Which is basically "Your testosterone levels drop"

Re: Ibuprofen alters human testicular physiology to produce compensated hypogonadism

#153

So back to good old aspirin? Acetaminophen slowly kills your liver and Ibuprofen messes with testosterone production.

Please note that acetaminophen/paracetamol is incredibly safe at normal doses and does not kill your liver.

It is only when you attempt to overdose (or if you have severely limited liver function) that you run out of the liver enzymes that break it down, causing liver damage.

Re: Ibuprofen alters human testicular physiology to produce compensated hypogonadism

#154
post #71

Earlier quoted context omitted.

OTOH acetaminophen is known to be toxic; is there an alternative here for non narcotic inflammation, fever, and pain relief that is shown NOT to have tradeoffs for use?

Kratom / Cannabis oh wait these are illegal so big pharma can milk their poisons.

Cannabis causes low T and gynecomastia, so not really

Re: Ibuprofen alters human testicular physiology to produce compensated hypogonadism

#155
post #71

Earlier quoted context omitted.

OTOH acetaminophen is known to be toxic; is there an alternative here for non narcotic inflammation, fever, and pain relief that is shown NOT to have tradeoffs for use?

Kratom / Cannabis oh wait these are illegal so big pharma can milk their poisons.

Here in Canada, Big Pharma are falling over themselves to get into the Cannabis business.

I honestly think the obstacle to Cannabis legalization in the US is social conservatism, not industrial lobbying.

Re: Ibuprofen alters human testicular physiology to produce compensated hypogonadism

#156
post #2

"Ibuprofen and hypogonadism — bench to bedside to misinterpreted hype?" at https://www.nature.com/articles/nrurol.2018.26 : > A recent study suggests modulation of luteinizing hormone signalling within the hypothalamic–pituitary–gonadal axis and downstream transcriptional effects caused by sustained ibuprofen use. However, this study cannot be used to draw any clinical conclusions regarding effects of ibuprofen on ma…

In curious how can they make a statement such as “the study cannot be used to draw any conclusions” without providing any kind of reasoning, and get published in Nature?

Re: Ibuprofen alters human testicular physiology to produce compensated hypogonadism

#157
post #48

Earlier quoted context omitted.

Ibuprofen is anti-inflammatory medication.

>Ibuprofen is anti-inflammatory medication. And an acetaminophen tablet is a painkiller. While your statement is in fact true, ibuprofen is still a better choice for a fever. The latter is also generally considered a safer alternative, especially in long-term use — even though alternating the two would be ideal.

Acetaminophen is actually a pretty dangerous drug that is pretty easy to overdose on. It’s been said if it were discovered today it would be a prescription drug.

On top of that numerous recent studies have shown many potential problems.

https://www.webmd.com/drug-medication/news/20150302/does-lon...

> Heavy use of acetaminophen is associated with kidney disease and bleeding in the digestive tract, the paper reports. The medication also has been linked to increased risk of heart attack, stroke and high blood pressure, the study authors noted.

> One cited study even showed that overuse of acetaminophen can increase a person's risk of early death as much as 60 percent, the study authors found.

Re: Ibuprofen alters human testicular physiology to produce compensated hypogonadism

#158
post #2

"Ibuprofen and hypogonadism — bench to bedside to misinterpreted hype?" at https://www.nature.com/articles/nrurol.2018.26 : > A recent study suggests modulation of luteinizing hormone signalling within the hypothalamic–pituitary–gonadal axis and downstream transcriptional effects caused by sustained ibuprofen use. However, this study cannot be used to draw any clinical conclusions regarding effects of ibuprofen on ma…

Sounds like the industry responding with "we cant really know guys, right?" I'm throwing away my Advil right now. Screw that.

I doubt anyone is interested in protecting ibuprofen from a commercial point of view. Generic ibuprofen is extremely cheap; if anything the industry would probably like people to stop using it so that they could sell novel NSAIDs.

Re: Ibuprofen alters human testicular physiology to produce compensated hypogonadism

#159
post #64

Earlier quoted context omitted.

This. Just had friends visiting. Their teenage son had had his wisdom tooth pulled last week. Dentist had then given him (as a standard practice?) prescription for Ibuprofen (800mg tabs?) AND some opioid based pain killer! Needless to say, latter they said went directly to trash after they realized what it contained and for ibuprofen they halved the dosage. To me and his parents this was pain management gone way over…

I just had wisdom teeth extraction a few weeks back. I was given 800mg Ibuprofen and Norco. The pain was bad enough to wake me up at night when the meds wore off — and I did take both. Oral surgery is no joke. It took me about 8 days to taper to 400mg Ibuprofen. These doctors don’t just give pills out randomly, they do it for a reason based on evidence and science. A side note is that my pharmacist made it very clear…

The pain varies wildly from person to person. A friend of mine was out of order for two weeks after having a single tooth removed. I had all 4 removed and recovered in a few days and without much painkillers.

IMHO the doctors should prescribe less at first and see if it would be enough, but I also get that they are overcrowded and the same patient coming back for just more painkillers might be a little too much.

Re: Ibuprofen alters human testicular physiology to produce compensated hypogonadism

#160
post #4

This is terrifying. I used to take a lot of ibuprofen for frequent headaches (much better now). Military doctors were overzealous with the 800mg prescriptions (double the OTC dose). I suppose I should just use naproxen or acetaminophen? Ibuprofen always seemed the most effective to me.

acetaminophen damages the liver and kidneys at an alarming rate. It should have been skipped prior to today.
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