Ibuprofen alters human testicular physiology to produce compensated hypogonadism
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Re: Ibuprofen alters human testicular physiology to produce compensated hypogonadism
#2"Ibuprofen and hypogonadism — bench to bedside to misinterpreted hype?" at https://www.nature.com/articles/nrurol.2018.26 :
> A recent study suggests modulation of luteinizing hormone signalling within the hypothalamic–pituitary–gonadal axis and downstream transcriptional effects caused by sustained ibuprofen use. However, this study cannot be used to draw any clinical conclusions regarding effects of ibuprofen on male androgenic or reproductive health. Thus, the andrological effects of its use remain unclear and would benefit from further investigation.
Re: Ibuprofen alters human testicular physiology to produce compensated hypogonadism
#3"Ibuprofen and hypogonadism — bench to bedside to misinterpreted hype?" at https://www.nature.com/articles/nrurol.2018.26 : > A recent study suggests modulation of luteinizing hormone signalling within the hypothalamic–pituitary–gonadal axis and downstream transcriptional effects caused by sustained ibuprofen use. However, this study cannot be used to draw any clinical conclusions regarding effects of ibuprofen on ma…
Sounds like the industry responding with "we cant really know guys, right?"
I'm throwing away my Advil right now. Screw that.
Re: Ibuprofen alters human testicular physiology to produce compensated hypogonadism
#4This is terrifying. I used to take a lot of ibuprofen for frequent headaches (much better now). Military doctors were overzealous with the 800mg prescriptions (double the OTC dose).
I suppose I should just use naproxen or acetaminophen? Ibuprofen always seemed the most effective to me.
Re: Ibuprofen alters human testicular physiology to produce compensated hypogonadism
#5600mg per day is an enormous dose, albeit not especially uncommon. I’d be more interested though in the effects of, say, 200 - 400mg per week.
Re: Ibuprofen alters human testicular physiology to produce compensated hypogonadism
#6Having read half the paper, the treatment group took 600mg ibuprofen daily for 14 to 44 days to induce the reported effect of compensated hypogonadism, though the 12 and 24 hour effects on testosterone were apparently easily detectable on ex vivo testicle samples. So, maybe if you need your testosterone, keep off the OTC pain medications. And probably don't donate samples of your testicle either.
Interesting paper though.
Re: Ibuprofen alters human testicular physiology to produce compensated hypogonadism
#7As someone who is XXY, I can’t help but wonder what, if any issues would be caused by a pregnant mother taking a lot of this.
Re: Ibuprofen alters human testicular physiology to produce compensated hypogonadism
#8Having read half the paper, the treatment group took 600mg ibuprofen daily for 14 to 44 days to induce the reported effect of compensated hypogonadism, though the 12 and 24 hour effects on testosterone were apparently easily detectable on ex vivo testicle samples. So, maybe if you need your testosterone, keep off the OTC pain medications. And probably don't donate samples of your testicle either. Interesting paper th…
Did the effect go away when they stopped the treatment? I can’t read it at the moment due to slow WiFi.
Re: Ibuprofen alters human testicular physiology to produce compensated hypogonadism
#9"Ibuprofen and hypogonadism — bench to bedside to misinterpreted hype?" at https://www.nature.com/articles/nrurol.2018.26 : > A recent study suggests modulation of luteinizing hormone signalling within the hypothalamic–pituitary–gonadal axis and downstream transcriptional effects caused by sustained ibuprofen use. However, this study cannot be used to draw any clinical conclusions regarding effects of ibuprofen on ma…
Sounds like the industry responding with "we cant really know guys, right?" I'm throwing away my Advil right now. Screw that.
I get what you're saying, but ibuprofen and acetaminophen save lives. The problem is the western (American?) tendency to self-medicate and to over medicate with really potent stuff. That shouldn't be as normal as it is.
Re: Ibuprofen alters human testicular physiology to produce compensated hypogonadism
#10600mg per day is an enormous dose, albeit not especially uncommon. I’d be more interested though in the effects of, say, 200 - 400mg per week.
It isn’t enormous at all. 400mg every 4 hours is the OTC dose (at least in the US). My prescription was 800mg.