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Ibuprofen alters human testicular physiology to produce compensated hypogonadism

ncbi.nlm.nih.gov

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Re: Ibuprofen alters human testicular physiology to produce compensated hypogonadism

#51

Post by SubiculumCode »

acct1771 wrote: post #36
gonyea wrote: post #9

Earlier quoted context omitted.

I get what you're saying, but ibuprofen and acetaminophen save lives. The problem is the western (American?) tendency to self-medicate and to over medicate with really potent stuff. That shouldn't be as normal as it is.

And acetaminophen reduces empathy, according to some convincing research. What's wrong with cannabis-derived solutions, again?

For those downvoting parent please see https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015806/

And others.

True or not, parent wasn't just making up the empathy-painkiller association.

Re: Ibuprofen alters human testicular physiology to produce compensated hypogonadism

#52

Post by jrowley »

docbrown wrote: post #50
bitL wrote: post #48

Earlier quoted context omitted.

Ibuprofen is anti-inflammatory medication.

>Ibuprofen is anti-inflammatory medication. And an acetaminophen tablet is a painkiller. While your statement is in fact true, ibuprofen is still a better choice for a fever. The latter is also generally considered a safer alternative, especially in long-term use — even though alternating the two would be ideal.

If you have a fever, why not both (as long as you’re hydrated)?

Re: Ibuprofen alters human testicular physiology to produce compensated hypogonadism

#53

Post by potiuper »

an_account_name wrote: post #39
scjr wrote: post #34

Earlier quoted context omitted.

I am not aware of any common uses of Ibuprofen and Acetominophen that saves lives?

Fevers kill. Ibuprofen and acetaminophen reduce fevers.

Fevers do not kill. Fever is a symptom, which is subjective, not a cause of death.

Re: Ibuprofen alters human testicular physiology to produce compensated hypogonadism

#54

Post by complector »

acct1771 wrote: post #36
gonyea wrote: post #9

Earlier quoted context omitted.

I get what you're saying, but ibuprofen and acetaminophen save lives. The problem is the western (American?) tendency to self-medicate and to over medicate with really potent stuff. That shouldn't be as normal as it is.

And acetaminophen reduces empathy, according to some convincing research. What's wrong with cannabis-derived solutions, again?

[flagged]

Re: Ibuprofen alters human testicular physiology to produce compensated hypogonadism

#55

Post by rjf72 »

defertoreptar wrote: post #38
jimmyswimmy wrote: post #6

Having read half the paper, the treatment group took 600mg ibuprofen daily for 14 to 44 days to induce the reported effect of compensated hypogonadism, though the 12 and 24 hour effects on testosterone were apparently easily detectable on ex vivo testicle samples. So, maybe if you need your testosterone, keep off the OTC pain medications. And probably don't donate samples of your testicle either. Interesting paper th…

> the treatment group took 600mg ibuprofen daily for 14 to 44 days to induce the reported effect of compensated hypogonadism That phrasing is misleading. We don't know if it takes 600 mg for 14 days "to induce" hypogonadism. The study didn't test for that. It only tested if there would be an effect, and as with most pilot experiments, it did so cheaply and quickly. That's the idea of small sample size experiments suc…

600mg is not a large dose. Ibuprofen over the counter recommends 400mg (two tablets) every 4-6 hours with up to 6 tablets (1200mg) per day.

Re: Ibuprofen alters human testicular physiology to produce compensated hypogonadism

#56

Post by burke »

> Our data demonstrate that ibuprofen alters the endocrine system via selective transcriptional repression in the human testes, thereby inducing compensated hypogonadism.

Interesting. I’m no doctor, but this sounds like a not-super-transient effect.

Amazing and slightly horrifying that they were able to measure this after a relatively short period of high-moderate sustained use.

Re: Ibuprofen alters human testicular physiology to produce compensated hypogonadism

#58

Post by sandworm101 »

potiuper wrote: post #53
an_account_name wrote: post #39

Earlier quoted context omitted.

Fevers kill. Ibuprofen and acetaminophen reduce fevers.

Fevers do not kill. Fever is a symptom, which is subjective, not a cause of death.

Fever can indeed kill. Raise the body temp a few degrees, no matter the cause, and things start going wrong very quickly. Google hyperthermia.

In fact, i cannot think of any disease that literally kills. Even with the big stuff like cancer or aids, it is always the symptoms that get you. They damage body systems and the decline of those systems (aka symptoms) eventually causes the cardiac arrest or internal bleeds that shut off nutrients to the brain. Those symptoms are just as lethal no matter thier cause. A massive fever that stops normal body chemistry, whether caused by flu or ebola, will kill you just the same.

Re: Ibuprofen alters human testicular physiology to produce compensated hypogonadism

#59

Post by TylerE »

lbotos wrote: post #25
couradical wrote: post #14

Earlier quoted context omitted.

How is that an enormous dose? The recommendation is 2x200mg every 4-6h. When doing competitive athletics, I probably took 1-3g of “vitamin I” a day. 600mg a day is barely above a single dose.

What were you taking it for? Pain reduction? (Curious, no judgement, trying to understand if there was any other reason)

It's an anti-inflammatory. Helps with all kinds of things - sore muscles, tooth aches - it's not really pain relief so much as it is things-that-cause-pain relief.

Re: Ibuprofen alters human testicular physiology to produce compensated hypogonadism

#60

Post by forkLding »

defertoreptar wrote: post #38
jimmyswimmy wrote: post #6

Having read half the paper, the treatment group took 600mg ibuprofen daily for 14 to 44 days to induce the reported effect of compensated hypogonadism, though the 12 and 24 hour effects on testosterone were apparently easily detectable on ex vivo testicle samples. So, maybe if you need your testosterone, keep off the OTC pain medications. And probably don't donate samples of your testicle either. Interesting paper th…

> the treatment group took 600mg ibuprofen daily for 14 to 44 days to induce the reported effect of compensated hypogonadism That phrasing is misleading. We don't know if it takes 600 mg for 14 days "to induce" hypogonadism. The study didn't test for that. It only tested if there would be an effect, and as with most pilot experiments, it did so cheaply and quickly. That's the idea of small sample size experiments suc…

600mg per day is the recommended normal adult dosage where doctor's recommend 200mg 3 times a day, although can also be recommended 1200mg. It's not a big dosage.

Doctors can also recommend an even higher dosage of 600mg 4 times a day to about 2400mg a day if needed.

Source: Https://www.nhs.uk/medicines/ibuprofen-for-adults/

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