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https://livertox.nih.gov/Ibuprofen.htm
"Rates of serum aminotransferase elevations during low dose, chronic ibuprofen therapy are comparable to those that occur with placebo controls (0.4%). However, higher rates of ALT elevations occur with high, full doses of 2,400 to 3,200 mg daily (up to 16%)."
This is terrifying. I used to take a lot of ibuprofen for frequent headaches (much better now). Military doctors were overzealous with the 800mg prescriptions (double the OTC dose). I suppose I should just use naproxen or acetaminophen? Ibuprofen always seemed the most effective to me.
The paper mentions that at issue are all NSAIDs, including aspirin, etc.
That said, like the OP, I used to also take lots of Ibuprofen for headaches, and unfortunately, Acetaminophen never seemed to work for more than an hour or two max (tested in "isolation" for 7+ days), while Ibuprofen could stop the headache cycle for a day+.
"Ibuprofen and hypogonadism — bench to bedside to misinterpreted hype?" at https://www.nature.com/articles/nrurol.2018.26 : > A recent study suggests modulation of luteinizing hormone signalling within the hypothalamic–pituitary–gonadal axis and downstream transcriptional effects caused by sustained ibuprofen use. However, this study cannot be used to draw any clinical conclusions regarding effects of ibuprofen on ma…
>Despite the excellent quality of the work, the main point to emphasize is the confusion that has arisen concerning the study conclusions versus the real-world relevance and application of its results.
Earlier quoted context omitted.
Sounds like the industry responding with "we cant really know guys, right?" I'm throwing away my Advil right now. Screw that.
I get what you're saying, but ibuprofen and acetaminophen save lives. The problem is the western (American?) tendency to self-medicate and to over medicate with really potent stuff. That shouldn't be as normal as it is.
On another note, maybe this will drive alternative treatments such as CBD/marijuana for those who need to sustain their pain relief.
Earlier quoted context omitted.
Sounds like the industry responding with "we cant really know guys, right?" I'm throwing away my Advil right now. Screw that.
I get what you're saying, but ibuprofen and acetaminophen save lives. The problem is the western (American?) tendency to self-medicate and to over medicate with really potent stuff. That shouldn't be as normal as it is.
What's wrong with cannabis-derived solutions, again?
I once had an extraordinarily low level of blood testosterone reading after I had taken Ibuprofen for a few days.
Having read half the paper, the treatment group took 600mg ibuprofen daily for 14 to 44 days to induce the reported effect of compensated hypogonadism, though the 12 and 24 hour effects on testosterone were apparently easily detectable on ex vivo testicle samples. So, maybe if you need your testosterone, keep off the OTC pain medications. And probably don't donate samples of your testicle either. Interesting paper th…
That phrasing is misleading. We don't know if it takes 600 mg for 14 days "to induce" hypogonadism. The study didn't test for that. It only tested if there would be an effect, and as with most pilot experiments, it did so cheaply and quickly.
That's the idea of small sample size experiments such as this. Try a big dose as see if you get an effect at all. If so, that's a jumping off point for more rigorous, expensive studies later on.
Earlier quoted context omitted.
I get what you're saying, but ibuprofen and acetaminophen save lives. The problem is the western (American?) tendency to self-medicate and to over medicate with really potent stuff. That shouldn't be as normal as it is.
I am not aware of any common uses of Ibuprofen and Acetominophen that saves lives?
Ibuprofen induced liver toxiticy: https://livertox.nih.gov/Ibuprofen.htm "Rates of serum aminotransferase elevations during low dose, chronic ibuprofen therapy are comparable to those that occur with placebo controls (0.4%). However, higher rates of ALT elevations occur with high, full doses of 2,400 to 3,200 mg daily (up to 16%)."