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How to sequence your own DNA at home

bradleywoolf.com

141–150 of 161 posts

Re: How to sequence your own DNA at home

#141

I don't want to sequence at home. But I do want to sequence it using a third-party that gives me all the raw data. I live in Europe and I'm just a simple consumer. Does anyone know how I can do this? What service would I use / you can recommend? Them not keeping it on their side would be a huge bonus of course but not sure I can ask for that much.

In Europe Dante (an Italian company) is excellent at this.

Re: How to sequence your own DNA at home

#142
post #12

Earlier quoted context omitted.

Nothing about this is the future. Sequencing at home will not solve any major problems. It's mainly a fun exercise to demonstrate that sequencing has been commodified.

Knowing exactly why I have high LDL because of a specific mutation on my DNA is very much the future, imo.

.... which does not need or really want home sequencing. That's clinical-grade with QC and high quality instruments, along with professional genetic analysis.

Re: How to sequence your own DNA at home

#143
post #12

Earlier quoted context omitted.

Nothing about this is the future. Sequencing at home will not solve any major problems. It's mainly a fun exercise to demonstrate that sequencing has been commodified.

I disagree, I sequenced with nebula genomics years ago.. you can understand risk factors for various problems so that you can start interventions that make sense way in advance.

Did you actually find any actionable results? When I had my genome sequenced professionally they told me I literally had no SNPs in my genome that were associated with deleterious mutations. And even if you do, there are only some treatments- and those treatments usually have clinically validated tests that are accurate.

Re: How to sequence your own DNA at home

#144

I've bee thinking about starting a company where I fish roots out of your sewer and identify the plant (by sequence if necessary) that you have to kill so your sewer doesn't collapse as soon as it otherwise would. $100 to stave off that $10000 sewer replacement for a few years would be worth it to a lot of people

https://www.envirodna.com/ https://www.naturemetrics.com/species-detection https://www.ednacollab.org/industry/ https://wilderlab.co/ These companies focus on environmental DNA - some are more on the level of local government monitoring, some are for private customers.

Isn't this one of the primary techniques with which covid levels are being monitored?

Re: How to sequence your own DNA at home

#145
post #118

Earlier quoted context omitted.

Honestly, you don't need someone's genetics for this to happen. They will find out more about you by scraping your socials and spending habits and driving habits. I think this whole fear is over blown anyway. I am in a genetic out group (schizoaffective disorder and yes my risk is genetic) and the benefits of getting my genetics run twice out weighed any risk that might have befallen me.

It's overblown _right now_ because this information is not broadly available. The fear is that pervasive access to this data would lead to e.g. you or your partner not getting insurance to pay for anything fertility-related, or you not getting hired for a job you want despite being otherwise qualified, or even that is less inclined to take you seriously because their perception of what schizoaffective means makes the…

I am homeless currently living with schizoaffective disorder (and OCD) by myself because no one wants to take care of people with mental illness so I have zero to lose.

My nephew died by suicide, I tried my mother and my brother tried. A whole family of pretty evident genes.

Re: How to sequence your own DNA at home

#146
post #144

Earlier quoted context omitted.

https://www.envirodna.com/ https://www.naturemetrics.com/species-detection https://www.ednacollab.org/industry/ https://wilderlab.co/ These companies focus on environmental DNA - some are more on the level of local government monitoring, some are for private customers.

Isn't this one of the primary techniques with which covid levels are being monitored?

They are pretty much the same, yes! Those eDNA providers usually use a wider range of primers (12S, 16S, COI etc.) to capture a range of invertebrates, vertebrates, plants etc. For Covid, since it's only that one virus, you can target only the one gene so it's a bit easier.

Re: How to sequence your own DNA at home

#147
post #64
post #56

This feels like the acme of narcissism. How much time and money are people willing to spend on navel gazing?

When you are taking care of your health, and need to learn more about your built-in limitations is it still narcissistic? At the bottom of the page there is a link to Sid Sijbrandij's cancer journey. He is one of the cofounders of GitLab. This is one of the coverages of his story: https://centuryofbio.com/p/sid

> When you are taking care of your health, and need to learn more about your built-in limitations is it still narcissistic?

Well, yes, if done in excess. Hypochondria is a narcissistic trait.

Re: How to sequence your own DNA at home

#148
post #94

Earlier quoted context omitted.

what is the attack vector btw?

That gives some probabilistic info to scraper. Like person might have genes that are: - susceptible to drugs abuse - or game addiction Bam - you get target ads - Indicate that any common substance is especially dangerous/harmful for him (think of allergies). So attacker might plan assassination or severe inconvenience by exposure to the substance and then claim he did not know

> That gives some probabilistic info to scraper. Like person might have genes that are: - susceptible to drugs abuse - or game addiction Bam - you get target ads

Or even more likely: “your insurance premium has now increased”, “your credit score is now degraded”.

Re: How to sequence your own DNA at home

#149

I don't want to sequence at home. But I do want to sequence it using a third-party that gives me all the raw data. I live in Europe and I'm just a simple consumer. Does anyone know how I can do this? What service would I use / you can recommend? Them not keeping it on their side would be a huge bonus of course but not sure I can ask for that much.

In Europe Dante (an Italian company) is excellent at this.

Uhm, no no. DanteLabs has a very bad reputation because it hasn't delivered results for many customers who sent their kits years ago.

Re: How to sequence your own DNA at home

#150

Earlier quoted context omitted.

If a service doesn't give you the raw data for some reason you should be able to get it with a GDPR subject access request.

Some DNA companies (FTDNA for one) play fast and loose with this. FTDNA gives you a vcf file, which contains the variant calls, but not the raw reads which those calls are made from (as in the BAM file). They do keep that data, because they charge extra for a BAM file download. It's almost certainly against the GDPR. Worse, I think they do it for anticompetitive reasons - they own the largest Y-DNA tree, and don't wa…

Storing genetic data is not against GDPR. It matters where they store it and who else has access to the data.
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