Hacker News Board Hacker News, browsed like a classic message board
Live data from Hacker News

What Ozempic does to the gut-brain axis

psychologytoday.com

Post reply on HN
Print view View original

231–240 of 555 posts

Re: What Ozempic does to the gut-brain axis

#231

Post by phil21 »

faangguyindia wrote: post #151
phil21 wrote: post #122

Earlier quoted context omitted.

Who is lying? I was fat because I ate too much. Why I ate too much is uninteresting to me. I also don’t have some moral hang up over it. Give me that easy button all day long so I can focus on shit in my life that actually matters. If it makes someone feel better about themselves to believe in woo-woo science that violates the laws of physics and ascribe magical properties to GLPs, why do you care?

>If it makes someone feel better about themselves to believe in woo-woo science that violates the laws of physics and ascribe magical properties to GLPs, why do you care? Why we should not care about putting people on drug who do can benefit from making lifestyle changes, being less sedentary and leaning about maintenance calories and how calorie surplus and deficit works? if there is no resistance, simply prescribin…

> being less sedentary and leaning about maintenance calories and how calorie surplus and deficit works?

Because it's useless advice that doesn't work in practice. As witnessed by decades of failure, with the only thing turning the tide on the obesity epidemic on a population scale being GLP-1 drugs.

> if there is no resistance, simply prescribing GLPs to average person may become a new normal.

Probably not ideal, but until Western society decides to change from the ground up it's better than the alternative which showed literally nothing but failure. One is something that works, the other is something that will take multiple generations to correct.

Re: What Ozempic does to the gut-brain axis

#232

Post by dotcoma »

catigula wrote: post #218
soared wrote: post #214

Earlier quoted context omitted.

Omeprazole is not great long term FYI - worth talking to your doctor or getting a second opinion to discuss.

I’ve been taking high doses long term for over a decade and I don’t really have any substantial issues.

Good for you, but this mere fact does not mean it’s ideal.

Not a doctor, but I would at least try to look into this. Best of luck!

Re: What Ozempic does to the gut-brain axis

#233

Post by dotcoma »

applfanboysbgon wrote: post #84
ceejayoz wrote: post #81

Earlier quoted context omitted.

> We also know there's a replication crisis in psychology and medicine… It seems unlikely to extend to bariatric surgery outcomes. > This idea that Americans are genetically pre-ordained to be fat seems like fanciful thinking. This idea that Americans are genetically pre-ordained to lack willpower seems like fanciful thinking.

Of course they aren't genetically pre-ordained to lack willpower. That's why they could stop being fat, if only they chose to. The issue is cultural, not genetic. You don't go from 12% obesity to 40% obesity in 40 years due to a genetic shift, but rather a cultural one.

The real shift happened in what BigFood started putting into their highly processed food, imho.

Re: What Ozempic does to the gut-brain axis

#234

Post by rnewme »

sublinear wrote: post #221
faangguyindia wrote: post #139

Earlier quoted context omitted.

>my body and mind are no longer is in starvation mode What does it mean? If a drug reduces your desire to eat food, wouldn't it also decrease your desire to eat food beneficial for your body? I think the effect most people want is to stop craving junk food but still eat nutritious food required for muscle growth and health.

If you want the real answer, people suck at shopping for groceries and don't know how or want to cook. Long before LLMs, there was a different but similarly misguided hype around making food more convenient. Making money off ignorance is not "innovation", but we live in a world convinced by arrogant and pretentious fearmongering liars. As always, just do it yourself. It's not that hard after all.

Do you know what food noise is?

Re: What Ozempic does to the gut-brain axis

#235

Post by toast0 »

faangguyindia wrote: post #151
phil21 wrote: post #122

Earlier quoted context omitted.

Who is lying? I was fat because I ate too much. Why I ate too much is uninteresting to me. I also don’t have some moral hang up over it. Give me that easy button all day long so I can focus on shit in my life that actually matters. If it makes someone feel better about themselves to believe in woo-woo science that violates the laws of physics and ascribe magical properties to GLPs, why do you care?

>If it makes someone feel better about themselves to believe in woo-woo science that violates the laws of physics and ascribe magical properties to GLPs, why do you care? Why we should not care about putting people on drug who do can benefit from making lifestyle changes, being less sedentary and leaning about maintenance calories and how calorie surplus and deficit works? if there is no resistance, simply prescribin…

We don't seem to care much about giving people access to caffeine, allergy pills, corrective lenses, and in many places alcohol and marijuana.

Why is it a problem if there's wider access to these drugs? So far, afaik, there's been no long term major adverse effects, and especially I've seen no reports of adverse effects that extend beyond use of the drug (as has been the case with previously popular weight loss drugs that could injure people's hearts).

We're 5 years since fda approval specifically for weight loss and 9 years since fda approval for type 2 diabetes. That's a pretty good amount of time to find serious problems, although certainly many withdrawn drugs were on the market for longer, ex wikipedia says Ranitidine was the biggest selling prescription drug in 1987, but was found to be problematic in 2019 (apparently a new formulation is available as of late 2025!)

Sure, there are other ways to work on weight, just like there are other ways to work on allergies and exercises some people say are effective for vision problems. But we don't force people to give up pets or move somewhere that has fewer triggering allergens, we let them take allergy pills; we let people use eyeglasses or contact lenses or have their eyeballs adjusted so they can see; etc. There's a tool that's effective for many people, why not use it?

Re: What Ozempic does to the gut-brain axis

#236

Post by derekja »

catigula wrote: post #218
soared wrote: post #214

Earlier quoted context omitted.

Omeprazole is not great long term FYI - worth talking to your doctor or getting a second opinion to discuss.

I’ve been taking high doses long term for over a decade and I don’t really have any substantial issues.

The primary concern is reduced stomach acid leading to nutrient deficiencies, particularly b12. There have been some long term studies correlating to dementia as a result. And some studies that have not found this. So the jury is still out, but keeping an eye on some nutritional markers is not a bad idea.

Re: What Ozempic does to the gut-brain axis

#237

Post by wincy »

Aaargh20318 wrote: post #75
9x39 wrote: post #55

Earlier quoted context omitted.

If they were a normal weight they would not have been prescribed the drug. The underlying issue is they're overweight because they eat too much. Anything more is speculation. There is usually no free lunch when it comes to pharma, and extrapolating long term or lifetime dependence as being equivalent to short term interventions is an unsupported leap.

That’s the problem with these new weight loss drugs. Ultimately they work by reducing food intake. For many people food is one of the few things in life that gives them some form of joy. I won’t ever take any drug that will take that away from me. Life is depressing enough as is. What we need is a weight loss drug that lets you eat unlimited amounts of food, preferably even suppressing the feeling of fullness, withou…

I’m on the max dosage of Zepbound and ate an entire six course meal at a Michelin star restaurant last year. It was an incredible experience. I just don’t eat an entire frozen pizza by myself, or box of zebra cakes where I’d then wake up with horrifying heartburn at three in the morning anymore. My life is so much better and my relationship with food is still totally fine. Sure I’ll have a treat sometime, but I’m not finding myself hungry at 11pm driving to the store to buy a box of them because I feel like I’m starving. I was well on the path to becoming diabetic and it felt like something I could barely control. When I’d try to diet I’d wake up shaking from night time blood sugar drops. All that hell is gone now.

Re: What Ozempic does to the gut-brain axis

#238

Post by klipklop »

faangguyindia wrote: post #176
dgabriel wrote: post #170

Earlier quoted context omitted.

I understand calorie balance. I've been on a diet since I was 12 years old, and am now approaching 50. I've lost and regained the same 60lbs about 4 times now. I have logged every bite that goes into my mouth, and lived with a constant hunger for as long as I could take it. Then I ate until I felt satisfied and gained it all back. I know how many calories are in anything, and I can eyeball any serving size. I've been…

I have no personal animosity toward you, but I've heard all this many times, so I'll respond accordingly. >I've been on a diet since I was 12 years old, and am now approaching 50. I've lost and regained the same 60lbs about 4 times now You can lose weight by crash dieting, which does not prove much. The first thing that comes to mind for people is simply: "I'll just eat very little and lose weight." It even works, bu…

This comes off as extremely condescending. I am pretty sure the person you are trying to give basic dieting advice already knows this. Why are you trying so hard to convince people to not take medication that helps them?

Re: What Ozempic does to the gut-brain axis

#239

Post by genericresponse »

faangguyindia wrote: post #176
dgabriel wrote: post #170

Earlier quoted context omitted.

I understand calorie balance. I've been on a diet since I was 12 years old, and am now approaching 50. I've lost and regained the same 60lbs about 4 times now. I have logged every bite that goes into my mouth, and lived with a constant hunger for as long as I could take it. Then I ate until I felt satisfied and gained it all back. I know how many calories are in anything, and I can eyeball any serving size. I've been…

I have no personal animosity toward you, but I've heard all this many times, so I'll respond accordingly. >I've been on a diet since I was 12 years old, and am now approaching 50. I've lost and regained the same 60lbs about 4 times now You can lose weight by crash dieting, which does not prove much. The first thing that comes to mind for people is simply: "I'll just eat very little and lose weight." It even works, bu…

Obesity is widely regarded as a chronic disease that includes the interaction of genetic and other factors with behavioral factors.

The unbelievably low success rate of diet and exercise programs for long-term weight reduction is widely documented and quite consistent with the earlier poster's experience.

Re: What Ozempic does to the gut-brain axis

#240

Post by ssl-3 »

hack1312 wrote: post #205
fwip wrote: post #172

Earlier quoted context omitted.

Additionally - GLP1 drugs work by changing those eating patterns.

But those changes don’t stick if the drug is discontinued.

Is the drug at risk of being discontinued? If so, then can that risk be quantified in any way?

(For comparison: Countless scores of diets are discontinued daily.)

Post reply on HN