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What Ozempic does to the gut-brain axis

psychologytoday.com

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Re: What Ozempic does to the gut-brain axis

#121

Post by Aaargh20318 »

buck746 wrote: post #108
Aaargh20318 wrote: post #82

Earlier quoted context omitted.

The problem with exercise is that our bodies are quite efficient with their energy usage. A few minutes of ‘calories in’ takes many hours of ‘calories out’ to burn. You can’t really exercise enough to offset the food you can eat in a day, even if you somehow were able to dedicate all your time to exercising you would still have to limit your food intake. Add to that the fact that exercise is mind numbingly boring and…

More importantly we have decades of irrefutable evidence that diet and exercise alone are about as effective as abstinence only sex education. It's great there are people that can just decide to eat less, but it's foolish to assume that can work for everyone. It's odd how people act as tho there's a "moral argument" against using a tool to help reach the goal. It feels a lot like the argument that "morals are from re…

> It's great there are people that can just decide to eat less, but it's foolish to assume that can work for everyone.

More importantly: I don’t want to eat less. I want to eat more. There is so much amazing food.

Re: What Ozempic does to the gut-brain axis

#122

Post by phil21 »

9x39 wrote: post #96
thereisnospork wrote: post #80

Earlier quoted context omitted.

Nonsense, one not just as easily say they are overweight because they aren't taking enough GLP-1 agonists. A patient with scurvy is proscribed vitamin C - they might even need to take it for the rest of their lives to stay healthy. Woe is them I guess for their chemical dependence.

I think you dislike the personal responsibility angle, which is fine but separate from caloric intake being the source of obesity. The fat is stored energy from food, it would violate conservation of energy otherwise. There's metabolism, food density, food availability, psychology, culture, economics, etc in play, but it's important not to lie to ourselves that the proximal cause of obesity isn't from over consumptio…

Who is lying? I was fat because I ate too much.

Why I ate too much is uninteresting to me. I also don’t have some moral hang up over it. Give me that easy button all day long so I can focus on shit in my life that actually matters.

If it makes someone feel better about themselves to believe in woo-woo science that violates the laws of physics and ascribe magical properties to GLPs, why do you care?

Re: What Ozempic does to the gut-brain axis

#123

Post by SubiculumCode »

y-curious wrote: post #6

I got severely downvoted in the past for badmouthing GLP1s here. Then I did my research, got on them and I take it all back. These things are on par with statins in terms of potential societal impacts.

GLP1s are one of today's real, true, modern miracles. It deserves a Nobel, but not to one person, but the teams upon teams upon teams that made it possible to get here.

Re: What Ozempic does to the gut-brain axis

#125

Post by SubiculumCode »

Aaargh20318 wrote: post #95
dyauspitr wrote: post #47

What’s the downside to this magical drug. There has to be a downside…

The downside is that they make you eat less thereby taking away one of the few things that make life worth living.

That is the silliest take ever. I am on GLP-1s, and I still enjoy my food..maybe more than ever before.

Re: What Ozempic does to the gut-brain axis

#126

Post by SubiculumCode »

crooked-v wrote: post #17

I'm curious if this post will also have the same phenomena I've seen before of people springing out of the woodwork to post moralizing comments about people shouldn't rely on drugs, about how actually GLP-1s are bad because they don't fix problems indefinitely with a single dose, about how people should fix their problems by just having more willpower, talking about 'but what about the unknown side effects?' of drugs…

And it surely did. Like clockwork. And it is annoying.

Re: What Ozempic does to the gut-brain axis

#127

Post by SubiculumCode »

meetingthrower wrote: post #20
randycupertino wrote: post #4

Earlier quoted context omitted.

I'm on GLP-1 and it's completely stopped my urge to online shop. I used to browse/shop for fun and out of habit or when I was stressed out or wanted a treat etc. Entirely resolved! I've also lost 40lbs on it.

To the others on this reply, I take 1/4 dose of the "clinical dose" and it has been life changing. I've lost 30 lbs. I've done that in the past, but for me that was harder than ranger school in the army. I LOVE food. Eating out and family dinner were always important to me. I was very worried that I would lose my pleasure in this. I haven't. But now I can just eat 1/2 slice of pie. Or 1 scoop of ice cream, etc etc. I…

Exactly my experience.

Re: What Ozempic does to the gut-brain axis

#128

Post by phil21 »

hackingonempty wrote: post #111
Aaargh20318 wrote: post #82

Earlier quoted context omitted.

The problem with exercise is that our bodies are quite efficient with their energy usage. A few minutes of ‘calories in’ takes many hours of ‘calories out’ to burn. You can’t really exercise enough to offset the food you can eat in a day, even if you somehow were able to dedicate all your time to exercising you would still have to limit your food intake. Add to that the fact that exercise is mind numbingly boring and…

> You can’t really exercise enough to offset the food you can eat in a day, even if you somehow were able to dedicate all your time to exercising you would still have to limit your food intake. People racing the Tour Divide, a 2700 mile solo unsupported bikepacking race through the Rocky Mountains, lose weight when riding their bikes 18 hours a day for 2-3+ weeks straight. They describe being unable to choke down eno…

Great? When I worked landscaping I would plow through 2-3 double quarter pounder meals every lunch break. And then a dominos pizza or three when I got home for dinner. Plus a gallon or two of full sugar soda throughout the day, and snacks.

It’s not practical in the least for the average office worker to outrun the fork. It’s just silly advice and pointless to even bring up. When it takes an hour or more of treadmill work to cancel a single donut you don’t need to think about it any longer than that.

You exercise for health. Not to lose weight. Until you are at the margins and can consistently create an extra 100-200 calorie deficit by walking for an hour every evening or whatever.

My three gym days a week don’t do much for the scale. Those are for physical and mental health. The weight part is in the kitchen.

Re: What Ozempic does to the gut-brain axis

#129

Post by SubiculumCode »

sandcat_ wrote: post #7
randycupertino wrote: post #4

Earlier quoted context omitted.

I'm on GLP-1 and it's completely stopped my urge to online shop. I used to browse/shop for fun and out of habit or when I was stressed out or wanted a treat etc. Entirely resolved! I've also lost 40lbs on it.

I'm curious, has it affected pleasure at all in other areas of life? Are things you used to enjoy still as enjoyable? Is it more the "addictiveness" of things that has dropped, as opposed to how enjoyable they are? (Never tried them myself, but very intrigued by them.)

First, I eat...but seem to get full fast. Its like before, my body would really delay sending me the "you're full now" signal while eating, but now it starts to come half way through my plate. But did I enjoy the food? Hell yeah. It might even taste better. And because I get full quicker, I eat slower so I can enjoy it more.

Outside of eating, I drink less, but do have occasional beers. I enjoy them.

And my relationships are not less fulfilling, and I don't find my life and work less interesting. All in all, the only thing I don't like is the occasional "egg" burps I get from it.

Re: What Ozempic does to the gut-brain axis

#130

Post by topgrain2 »

yakz wrote: post #70
topgrain2 wrote: post #58

Earlier quoted context omitted.

People talk past each other on this because for an individual it technically can work, and sometimes does, but on a population level, as extensively studied by people whose job it is to study that, it definitely does not work. Even with tons of regular attention from professionals and a cohort selected to have above-average motivation, it’s surprisingly poorly-performing (and that’s a crazy expensive level of interve…

I think it'd be more accurate to say that informing people that they should change their behavior doesn't work. A person changing their behavior can escape obesity. The reality is that most people won't be able to change their behavior without some other kind of assistance.

Even with extensive assistance (which is way too expensive to widely deploy) outcomes are weak.

Last I checked, researchers in the specific area of high-touch weight interventions were excited that they finally had a tool that might more-than-barely work… in glp-1 agonists.

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