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How long til we're all on Ozempic?

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Re: How long til we're all on Ozempic?

#481

Post by confidantlake »

arcticbull wrote: post #105
rootusrootus wrote: post #10

I'd think it more likely that it'll be one of the next generation drugs, but I do agree with the premise that it will be really common. A few weeks ago I started a low dose of tirzepatide (aka Mounjaro, aka Zepbound) and the side effects are interesting. The biggest negative, which just takes adjustment, is drastically lower stomach capacity. Used to be that two eggs and two pieces of toast was breakfast. Now I bette…

> "Just eat less and exercise more" is trite. If it were that easy, we'd all be in fantastic shape. Studies show it just doesn't work. There was a massive (18,000,000 people) cohort analysis published in 2023 that showed the likelihood of someone losing 5% of their body weight in any given year was 1 in 11 and the likelihood of going from severely obese to normal weight is 1 in 1667. https://www.ncbi.nlm.nih.gov/pmc/…

It works in the same way as crossing the finish line first works to win a race. Of course it works, do that and you win 100% of the time. It is not that it doesn't work, it is that it is extremely difficult to do.

Re: How long til we're all on Ozempic?

#482

Post by op00to »

rory wrote: post #428
cubefox wrote: post #110

Earlier quoted context omitted.

And apparently the pure manufacturing cost for Ozempic is relatively low: > the active drug in Ozempic can be produced for about 29 cents for a month’s supply, or 7.2 cents for a typical weekly dose, the research found. It’s not cheap to make — semaglutide costs over $70,000 per kilogram. But only a tiny quantity of the drug is used in each weekly dose. > https://fortune.com/europe/2024/03/28/ozempic-maker-novo-nor..…

By chance I just talked to someone with deeper knowledge on this and they said the current constraint is actually ramping up supply of the delivery mechanism, not the drug. I have zero expertise on this, but would be curious if anyone knows what's special about Ozempic delivery that can't be served by a commodity syringe.

> what's special about Ozempic delivery

People don't want to use a commodity syringe. People are scared of needles. The autoinjectors take most of the fear out of it.

Re: How long til we're all on Ozempic?

#483

Post by pixl97 »

lol768 wrote: post #319

> How long til we're all on Ozempic? It's genuinely quite depressing that so many people in the United States have a weight problem that the overwhelming majority of the population would benefit from this and headlines including "we are all" are not inaccurate. I don't think other countries are necessarily perfect here, but 74% of Americans don't have a healthy weight when you look at their BMI. That's a staggering s…

>I don't think other countries are necessarily perfect here,

America first... the rest of the world is playing catch up as quickly as possible.

>In March of 2023, the World Obesity Federation (WOF) released a report(Link downloads document) stating that by 2035 over 4 billion people – more than half the world’s population – will be obese. >and the priority should absolutely be non-pharmaceutical interventions.

Illegal. Or is should say Coca Cola can and will fight you to the death the moment you try. If you stand between the junk food companies and advertisers you will have an army of lawyers fighting you 'tobacco industry' style for the next 50 years.

Until the shit is off our shelves and out of our ads nothing will change.

Re: How long til we're all on Ozempic?

#484

Post by rootusrootus »

pugets wrote: post #341
arcticbull wrote: post #105

Earlier quoted context omitted.

> "Just eat less and exercise more" is trite. If it were that easy, we'd all be in fantastic shape. Studies show it just doesn't work. There was a massive (18,000,000 people) cohort analysis published in 2023 that showed the likelihood of someone losing 5% of their body weight in any given year was 1 in 11 and the likelihood of going from severely obese to normal weight is 1 in 1667. https://www.ncbi.nlm.nih.gov/pmc/…

It does work. It couldn't not work. Each day of your life, you choose to do one of three things: 1. Consume more calories than your body will need to function 2. Consume as many calories as your body will need to function 3. Consume fewer calories than your body will need to function When you consume more energy than you require, your body stores the remainder as fat. When you consume less energy than is required, yo…

> choose

You're letting that word do some very heavy lifting.

> To make a comparison

I think the comparison is very weak, very superficial. The human body is way more complex than CICO. But your comparison does have some intuitive value -- there are more than a few people who consistently spend every penny they make, and sometimes more, just trying to survive. We don't see a lot of them on Hacker News, to be sure.

Re: How long til we're all on Ozempic?

#485

Post by JamesBarney »

mayukh wrote: post #391
mlsu wrote: post #381

Earlier quoted context omitted.

My view about obesity has shifted dramatically since Ozempic came out. Before this, I didn't think about it too much (I am not obese myself). I notice now that there is a LOT of judgement, bias(?), around obesity, that people, obese or not, carry with them [1]. I certainly carried that bias, and the reason I noticed it was because Ozempic is literally an external substance that you take that simply makes obesity go a…

Obesity is a side effect of the industrial food production system in advanced economies that is slowly spreading all over the globe. How about alcohol and smoking ? Is that the same as obesity then

Neurologically addiction works very differently than obesity and research says longterm sobriety is far easier to maintain than long term weight loss.

Re: How long til we're all on Ozempic?

#486

Post by triceratops »

amatecha wrote: post #19

This article seems to frame things in such a strange way. Maybe instead of trying to get everyone obesity medication, we can instead educate society so we all understand nutrition and diet and can combat the ever-persistent forces of corporations pushing unhealthy food on us?

If we could do that through education, then we'd have made it illegal for corporations to push unhealthy food.

Re: How long til we're all on Ozempic?

#487

Post by kristjansson »

jodrellblank wrote: post #304
vundercind wrote: post #265

Earlier quoted context omitted.

It’s been studied pretty well. Possible effective solutions to the US obesity epidemic are pretty much limited to: 1) Radically alter aspects of food culture, work culture, social policy, and business regulation. 2) Magic pill (/injection) There appears to be no imminent progress on the many parts of #1 that need serious work, so if we want a big turn-around in the next half-century, #2 has suddenly and surprisingly…

From the article " Estimates suggest GLP-1s can reduce body weight by at least 15% when taken regularly ". That's a 5'10" man starting at 250lbs (obese, BMI > 35) and finishing at 220lbs (obese, BMI >30). Or a 5'10" man starting at 220lbs (obese) and finishing at 187lbs (overweight, BMI > 26). It ain't nothing, but that's not a magic pill which will fix the obesity epidemic. And these people have skipped changing the…

N.B. the claim from the quote is 'at least 15%', many users will realize larger benefits.

Re: How long til we're all on Ozempic?

#488

Post by sumeruchat »

valval wrote: post #318
gcr wrote: post #281

Earlier quoted context omitted.

We have good food, but you won't find it on "The Easy Path." The Easy Path is that gentle encouragement to hit up Chipotle for lunch, because it's "right there." The Easy Path says dinner's hard and you've had a long day, so get something simple, like take-out or microwave. The Easy Path is entropy. The Easy Path is self-care over struggle. The Easy Path is simple carbs shown on prominent display in store shelves. Th…

Get ground beef in the supermarket, it’s cheap and takes 7 minutes to cook. If that’s all you eat you can’t be fat and out of shape. You also won’t be hungry. At some point blaming society isn’t going to cut it.

If the only option to stay healthy is to regularly eat ground beef from the supermarket wouldnt you say society has f**ed things up pretty badly :)

Re: How long til we're all on Ozempic?

#489

Post by y1n0 »

apwell23 wrote: post #430
itronitron wrote: post #423

Earlier quoted context omitted.

[flagged]

They don't need marketing team writing posts on HN. The drug sells itself and even shortages all over the world.

It is pretty awesome . I’ve been on tirzepitide for a couple months. I’ve lost about 25lbs which is about 8% of my starting weight. I eat a lot less, but have not spontaneously changed what I eat. 50 years of bad habits take time to change.

But I atleast believe change is possible now. I’d pretty much given up. Every time I tried to go on a diet, I’d end up heavier than when I started. Not joking.

In 2009 I did have a winning streak on low carb keto, lost like 75lbs. Gained it back and more over the next couple years though. I’ve tried many times to get back into keto / low carb but have not been successful for more than a few weeks.

This is the first thing I’ve done for weightloss that has legit results that are personally shocking.

I’m very concerned about how to make changes long term. I don’t have a track record of making long term life changes, but I’m going to do my best with this opportunity.

Re: How long til we're all on Ozempic?

#490

Post by tjohns »

pinko wrote: post #443
tjohns wrote: post #399

Earlier quoted context omitted.

Studies have show most people rapidly regain the weight once they stop taking GLP-1 drugs. The dysfunctional biochemical processes that contributed to overeating are still present if you discontinue the drug. Your body has a natural set-point for the weight it wants to be at, and the hunger and food noise comes right back as your body tries to get you back to your old weight. It's possible that after after a long eno…

Is the idea of a set-point settled medical/scientific fact, or still a disputed theory?

It's still a theory. We definitely don't know the underlying mechanism(s) of action, and it's likely there's more hidden complexity there.

But rapid weight gain after weight loss (until you arrive somewhere near your old weight) is at least a well observed experimental effect. About 80% of people who lose weight, through any means, will revert back to their old weight.

Source:

https://www.ncbi.nlm.nih.gov/books/NBK592402/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3673773/

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