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Yeah but you also fall for fake documentaries about how HPV vaccine is dangerous.
Moderna's mRNA cancer vaccine works better than thought
121–130 of 258 posts
Re: Moderna's mRNA cancer vaccine works better than thought
#122Earlier quoted context omitted.
If by "free" you mean that taxpayers payed huge amounts of money then sure...
It was like $30 a dose or less. Super cheap. Egad.
Not to mention saved significant hospital costs as people were unwell but not sick enough to require more intensive and expensive treatment.
Re: Moderna's mRNA cancer vaccine works better than thought
#123Earlier quoted context omitted.
I would argue that any person isolating for 10 years will for sure have very significant health drawbacks, so that would also have to be factored in.
You mean in terms of immune system not having been exposed to enough pathogens?
No, it's a myth (albeit a popular one) that the human immune system benefits from being "toughened up" by actual pathogens. It's more about calibration by non-pathogens we co-evolved with.
Re: Moderna's mRNA cancer vaccine works better than thought
#124Earlier quoted context omitted.
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This does not appear to be a preventative treatment. It treats existing melanoma by inducing the body to produce antibodies against it, no?
Not just antibodies, but it will stimulate a broad class of immune cells.
And yes, the name vaccine is misleading. They should use immunotherapy.
Re: Moderna's mRNA cancer vaccine works better than thought
#125Earlier quoted context omitted.
You should do the healthy things to avoid cancer in the first place, but once you are diagnosed with a cancer with high mortality rate, it's a whole different calculation in terms of risks vs benefits compared to Covid-19.
Indeed. My view on vaccines is that they are not a cure but act as prevention agents.
This is a treatment
Re: Moderna's mRNA cancer vaccine works better than thought
#126Earlier quoted context omitted.
Indeed. My view on vaccines is that they are not a cure but act as prevention agents.
There's multiple vaccines that can also work after you've been exposed to a pathogen. In many such cases risks vs benefits will change by the event. For example rabies vaccines is not given to everyone, however after you get rabies you will be given that vaccine. Vaccine in this case is a less harmful training tool to prepare you for the more harmful pathogen that may still be reaching its peak strength. You can thin…
>For example rabies vaccines is not given to everyone
If you could spread something as bad as rabies by sneezing. You would see actual mandatory vaccinations, not the mild nudge people have been complaining about the last three years.
Re: Moderna's mRNA cancer vaccine works better than thought
#127Earlier quoted context omitted.
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mRNA will eventually save the day for everyone, including for perfectly healthy individuals, but to me as a healthy 40yo person, with no known immunity issues, not overweight etc. etc. it is in my opinion still too risky to take just like that. It's an interesting take. From what we know so far, the risk from taking vaccine is much smaller than from covid infection. You might counter this with highlighting the "so fa…
It's not a dichotomy. The vaccine is effectively only for a couple of months so you have to compound the effects of the vaccine PLUS the effects of infection. You also don't know if the effects of the vaccine are cumulative with each new booster.
And that's even assuming it's effective in the first place. The "it reduces symptoms" mantra is gaslighting since the whole point of its accelerated approval and forced application was for the reduction of transmission.
Re: Moderna's mRNA cancer vaccine works better than thought
#128Earlier quoted context omitted.
What
For an individual it is a formula of should_vaccinate = (risk_of_getting_covid_19 * bad_outcomes) - (bad_outcomes_from_vaccines + risk_of_getting_covid_19_after_vaccine * bad_outcomes_of_covid_19_after_vaccine) > 0 On the group level you would have to consider the damage on the group level as well from not getting vaccinated due to increase of covid-19 spread, and increased hospitalisation levels. On the global commu…
However, pretty much any real world person doing those calculations and arriving at the conclusion that they're better off not getting the vaccine is engaging in motivated rationalization rather than reasoning. Almost no one is actually living as a hermit, unlikely to ever be exposed to covid. And just about everyone who will be exposed will be safer having had the vaccine, considering all the risks and probabilities you listed.
Re: Moderna's mRNA cancer vaccine works better than thought
#129Earlier quoted context omitted.
IIRC from when Moderna started getting hot back in 2012 the preclinical trials weren’t going well. I think those were running ca. 2004–2005. Moderna took the infectious disease approach.
This is an oversimplification, but: Moderna mostly took an initial infectious disease approach because extant mRNA formulations at the time provoked too much of an immune response that neutralized the effectiveness of subsequent dosing. There's a goldilocks amount of immune response you want-- too little and the immune system doesn't learn the antigens you'd like, but too much makes it miss the mark and focus too muc…
huh that sounds exactly like machine learning overfitting vs generalization
Re: Moderna's mRNA cancer vaccine works better than thought
#130Earlier quoted context omitted.
People monitored via 5g by the angry agi goddess. Truly, this flat earth of our’s is magnificent. Thanks for reminding me of that.
Ridiculing people who are worried about long term effects of something that has been in use for only a few years is such an HN thing. There's countless precedent for things once touted as being safe to turn out incredibly damaging. We just don't know the long term effect yet. Please spare me with the "but there's no mechanism for it to do harm!!!!!" the same was said for all the other drugs that ended up causing canc…
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