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One sleepless night can rapidly reverse depression for several days in mice

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Re: One sleepless night can rapidly reverse depression for several days in mice

#231
post #197

Earlier quoted context omitted.

A lot of non-psychiatrist doctors prescribe SSRIs around the world, and that's a very good thing. These drugs are safe.

Please don’t make such blanket statements. They can have many harmful side effects, including sexual dysfunction.

I think OP meant to say, these are not drugs is not something you can OD with easily and kill yourself, not that they are side effect free .

Re: One sleepless night can rapidly reverse depression for several days in mice

#232
I’ve worked only two places my whole life: a tech company and an investment bank. Each had the work life balance you’d expect. When I started at the investment bank my depression stopped entirely. I always wonder if depression is something you experience if your hierarchy of needs is completely met. It’s like a switch flipped and I went from searching for meaning to animalistic survival mode.

Tangentially related, my religion has a strict health code and teaches to refrain from oversleeping. Not the inverse.

Re: One sleepless night can rapidly reverse depression for several days in mice

#233

Having suffered from severe depression for over forty years, this reminds me of when I was 17, 18, etc. and suddenly discovered that if I stayed up for two days, the problem went away. So I knew this a very long time ago; but it always seemed to me that, besides smoking, this was just about one of the worst habits you could develop. By my mid-twenties, I had stopped.

I recently was forced off of SSRIs after nearly ten years because I lost my psychiatrist and couldn't get a new one because the waitlists were ridiculous. After 10 years on them, the next 6 months were absolute hell (i legit thought at one point I might go full Joaquin Phoenix in Joker) but I made it through, no small part thanks to my wonderful amazing wife. Rebound depression have been an issue - though in general…

Sometimes I wish I wasn't so cynical, but I've suspected that SSRIs are a preferred treatment because it is almost impossible to get off of them. They say "It can take up to a month for it to work" is just a way to make sure dependency is strong enough by that point to make withdrawal unbearable. Many people don't fully understand the concept of withdrawal or chemical dependency, and will think the "medicine" works because they feel awful without it.

Re: One sleepless night can rapidly reverse depression for several days in mice

#234

> researchers induced mild, acute sleep deprivation in mice How can sleep deprivation be both mild and acute?

In medicine, describing a disease as “acute” denotes that it is of recent onset; it occasionally denotes a short duration, as opposed to “chronic”.

Re: One sleepless night can rapidly reverse depression for several days in mice

#235
post #224

Earlier quoted context omitted.

Trazodone felt like a Nuke to me, tried it for sleep but whew what a crazy strong (bad) feeling it gave me.

I’m glad to be seeing this because I went down all the way to 25mg. My doctor said there was no way I was getting side effects at that dose, but I felt awful every morning for the first 4 or 5 hours of the day.

Everybody has different side effects. My ADHD meds have basically had horrible effects for me that slowly crept in over a matter of months. Like it was so slow I had no idea it was from the meds. I was on low doses that should not have caused any side effects according to my doc.

Re: One sleepless night can rapidly reverse depression for several days in mice

#236

Earlier quoted context omitted.

I recently was forced off of SSRIs after nearly ten years because I lost my psychiatrist and couldn't get a new one because the waitlists were ridiculous. After 10 years on them, the next 6 months were absolute hell (i legit thought at one point I might go full Joaquin Phoenix in Joker) but I made it through, no small part thanks to my wonderful amazing wife. Rebound depression have been an issue - though in general…

Just a side note for anyone reading: you can get an SSRI prescription from your GP (general practitioner i.e. normal doctor) you don’t need to go through a psychiatrist. This is especially true if you are at risk for withdrawal, they will want to prevent that.

In Australia it’s standard for a GP to prescribe SSRIs.

Re: One sleepless night can rapidly reverse depression for several days in mice

#237

Earlier quoted context omitted.

> but now many GP's dismissed the symptoms of women's post-partum depression Weird example given you're arguing against GPs prescribing antidepressants because patients may lie. And I'd like to see someone lying to get SSRIs out of all the possible choices.

I'm arguing that in the US doctors can prescribe all medications regardless of their specialty (because it's true) and that it's not always a good idea, for example if the doctor is not familiar with recognizing the side effects which are outside of his specialty. (because that's also true) Your shrink is not going to prescribe you statins, as an example, but they could. It's important for a GP to recognize depressio…

In the US it’s common for a GP to prescribe SSRI’s. https://bmcprimcare.biomedcentral.com/articles/10.1186/s1287...

More broadly, in rural settings specialists are often impractical to access. So, the best possible standard of care is effectively off the table.

Re: One sleepless night can rapidly reverse depression for several days in mice

#238

My body does insanely badly with poor sleep. The worst feedback loop is when nighttime eczema itchiness kills my sleep quality which increases my stress which increases my eczema symptoms... But I've also been chronically depressed since childhood.

[dead]

Re: One sleepless night can rapidly reverse depression for several days in mice

#239

Earlier quoted context omitted.

My anxiety now is that using THC to sleep will cause issues long term. But without it I literally cannot get to sleep anymore. Edit: I regret pulling focus off parent comment and OP, but also deeply appreciate everyone’s comments.

I had a period when I used THC (edibles) for sleep every night. This was one of the worst things I have ever done to myself. At first, you don't notice much side effects, but slowly it creeps up on you. It makes you depressed, depletes of any motivation, gives brain fog and you may just feel weird over all. When I quit I was amazed by how much better I started feeling and by how much my cognitive function improved. I…

> It makes you depressed, depletes of any motivation, gives brain fog and you may just feel weird over all.

Meh, I was like that prior to using THC. I will admit that it can sometimes increase brain-fog the next day. But I'd say the pros and cons are pretty 75/25 split for me.

Re: One sleepless night can rapidly reverse depression for several days in mice

#240

Earlier quoted context omitted.

I recently was forced off of SSRIs after nearly ten years because I lost my psychiatrist and couldn't get a new one because the waitlists were ridiculous. After 10 years on them, the next 6 months were absolute hell (i legit thought at one point I might go full Joaquin Phoenix in Joker) but I made it through, no small part thanks to my wonderful amazing wife. Rebound depression have been an issue - though in general…

Sometimes I wish I wasn't so cynical, but I've suspected that SSRIs are a preferred treatment because it is almost impossible to get off of them. They say "It can take up to a month for it to work" is just a way to make sure dependency is strong enough by that point to make withdrawal unbearable. Many people don't fully understand the concept of withdrawal or chemical dependency, and will think the "medicine" works b…

I mean, obviously removing a serotoninergic med will change your homeostasis.

The real reason SSRIs are so popular is that they work (not always, but often to some extent) and for depression it's much cheaper to make a pill than book a therapists time

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