Once I go past 24hr I get really loopy and giggly.
Not sleeping for over 72 hours is the threshold for insanity.
I was awake that long once. I can understand why that threshold exists
One sleepless night can rapidly reverse depression for several days in mice
191–200 of 312 posts
Re: One sleepless night can rapidly reverse depression for several days in mice
#192I'm not depressed but just in case, time to go clubbin' like I'm nineteen again.
Weirdly I am in my 60s and have no trouble pulling all-nighters. I went clubbing like twice in my 20s and found it dull af, but coding all night is still not a problem for me.
I have always been an atrocious sleeper.
Re: One sleepless night can rapidly reverse depression for several days in mice
#193> "You can imagine certain situations where there is a predator or some sort of danger where you need a combination of relatively high function with an ability to delay sleep."
I think these predator vs. human situations are sometimes exaggerated to prove a point. Not that it can't be, it's just that these articles go straight into it with no pondering on sight. Similar analogies and misconceptions apply to fasting and paleo diets, sparking controversy on how prehistory behavior, human evolution and healthy habits in the 21st century all link up (or don't).
Humans have been naturally selecting on so many things - it's just as easy to say the brain responds with dopamine giddiness to protect itself from psychosis after a sleepless night caused by... eating bad food, hunger, insect bites, thirst, etc. No need to bring saber-tooth cats into the equation just for the clickbait.
Re: One sleepless night can rapidly reverse depression for several days in mice
#194Earlier quoted context omitted.
You can't put all people on a scale like that, less intelligent vs more intelligent. Some people are great with letters and words and spot typos quickly, some just don't see it as easily. They can still be very intelligent in other aspects. People are different.
You know, you are right. I agree, but it still drives me nuts seeing this, maybe it's just ignorance? I expect a higher standard from a .edu website
If this helps any, Siri NEVER seems to get this right, always preferring the contraction over the possessive. As a syntax/grammar fanaticist who is also old I rely on Siri for dictation and she has sunk embarrassingly low these last few years. I have to spend a long time correcting any message of reasonable length for this reason.
It has made me much more sympathetic to errors like this, but I cannot begin to tell you how offended I too feel when so-called educators don't proofread.
Don't get me started on emails from middle and high schools.
Re: One sleepless night can rapidly reverse depression for several days in mice
#195Once I hit my 40s, staying up too late causes a sleep hangover that would last a couple of days. Gone are my days of playing Ultima IV all night and feeling giddy in the morning.
One of the cruelest aspects of whatever kind of insomnia I have is that while I normal get only 2-3 hours of sleep per night and feel disabled most of the day, every 3-5 years I get maybe 8-9 hours, and I have a pounding headache for the first 10 or so hours after I wake up.
Re: One sleepless night can rapidly reverse depression for several days in mice
#196Weird, whenever I pull an all nighter my mood is usually noticeably depressed for the following two days. I also used to be a bit of an insomniac, and one sleepless night could easily throw off my circadian rhythm, creating all sorts of extra anxiety, which translates into demand avoidance, stress and furthering depression.
Is your normal state depressed though? I don’t think it works for “normal” people.
I was diagnosed with dysthymic depression a little over 20 years ago. Therapy helped reset my expectations for myself, meds keep me regular.
I had a stint of a few years off of medication to see how it went, thinking that I was sufficiently practiced at introspection to know if I needed to start again.
I was very wrong, and put it off far too long. I've been back on medication for about 7 years and don't plan on stopping, ever.
Re: One sleepless night can rapidly reverse depression for several days in mice
#197Earlier quoted context omitted.
GPs routinely prescribe SSRIs. Even pediatricians. At least in the US.
A lot of non-psychiatrist doctors prescribe SSRIs around the world, and that's a very good thing. These drugs are safe.
Please don’t make such blanket statements. They can have many harmful side effects, including sexual dysfunction.
Re: One sleepless night can rapidly reverse depression for several days in mice
#198Once I go past 24hr I get really loopy and giggly.
Not sleeping for over 72 hours is the threshold for insanity.
I had a long tech writing session once and at about 48 hours I started to hallucinate. Mentioned it to my girlfriend, and she drove the 70+ miles to my job to keep me company.
Re: One sleepless night can rapidly reverse depression for several days in mice
#199Earlier quoted context omitted.
I recently was forced off of SSRIs after nearly ten years because I lost my psychiatrist and couldn't get a new one because the waitlists were ridiculous. After 10 years on them, the next 6 months were absolute hell (i legit thought at one point I might go full Joaquin Phoenix in Joker) but I made it through, no small part thanks to my wonderful amazing wife. Rebound depression have been an issue - though in general…
Just a side note for anyone reading: you can get an SSRI prescription from your GP (general practitioner i.e. normal doctor) you don’t need to go through a psychiatrist. This is especially true if you are at risk for withdrawal, they will want to prevent that.
This works unless you GP is a huge jerkface in which case find a new one.
Just be honest: tell your GP that your previous provider quit/retired/changed insurance. Bring your prior RX bottles or paperwork. Let them know you have an appointment with your new provider on X date and ask them to cover you until then.
I've done this when changing insurance (twice) and when moving states (New provider had a waitlist. First time she wrote one month then when I reported the waitlist situation she ended up covering it for 3-4 months).
Re: One sleepless night can rapidly reverse depression for several days in mice
#200Having suffered from severe depression for over forty years, this reminds me of when I was 17, 18, etc. and suddenly discovered that if I stayed up for two days, the problem went away. So I knew this a very long time ago; but it always seemed to me that, besides smoking, this was just about one of the worst habits you could develop. By my mid-twenties, I had stopped.
My anxiety now is that using THC to sleep will cause issues long term. But without it I literally cannot get to sleep anymore. Edit: I regret pulling focus off parent comment and OP, but also deeply appreciate everyone’s comments.
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