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Taurine deficiency as a driver of aging

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Re: Taurine deficiency as a driver of aging

#281

Post by voytec »

insanitybit wrote: post #276
voytec wrote: post #259

Earlier quoted context omitted.

David Sinclair wrote in "Lifespan"[1] that they extended mice lifespan by (iirc) something like 40% but amounts of resveratrol used was something like mentioned 750-1000 wine glasses daily when translated to humans. While Wikipedia suggests that resveratrol is not proven to help with anything, I'm still taking 600mg in the morning, along with 600mg ALA and 100mg of CoQ10. Placebo is an effect, too. [1] https://en.wik…

https://www.youtube.com/watch?v=vGmmBJq0NNo I think at this point Sinclair has lost a lot of credibility

Thank you. Saddening but informative.

I was chatting about resveratrol this very week with a colleague, ex pro athlete, writing about "Nutrition in Sports" for his PhD. Looking forward to discussing these findings with him.

Re: Taurine deficiency as a driver of aging

#282

Post by BizarroLand »

philipov wrote: post #260
reaperman wrote: post #229

Earlier quoted context omitted.

There are a lot of amino acids which the human body can produce that nonetheless show clinical effects when additional amounts are ingested. I don’t understand the logic either but I’ve decided the human body has a billion things yet unknown to science so I take macro effects at face value even if I can’t learn an underlying mechanism for them. As a side note, a lot of weightlifters believe taurine reduces muscle cra…

Maybe there's a benefit to not needing to spend the energy or raw materials needed to synthesize something yourself? The large amounts needed might reflect that outsourcing the production is inefficient.

That makes me wonder how much of the physiological lifecycle we can offload the external processes and how much effect would that have on a human being?

We know, for instance, that connecting the circulatory system from an older animal to a younger one will cause the body of the younger animal to spend energy healing the cellular damage of the older one and can cause the older one to become younger by the markers we measure cellular age.

This is obviously unsustainable for any long term effect, and there are wild issues to consider with regards to the morality of doing this with human beings, but should the science advance to the point where we can grow genetically compatible functional organs, what harm would there be in having young custom grown organs attached to you, offloading everything that can be offloaded (pumping blood, secreting hormones and fresh stem cells, taking in extra oxygen, filtering out wastes, all of the things that your body has to work to do on its own)?

Do you think we would live longer, healthier, younger and more beautiful lives or would we become monsters permanently attached to backpacks stuffed to the brim with biological horror?

Re: Taurine deficiency as a driver of aging

#284

Post by tonymillion »

mtlmtlmtlmtl wrote: post #245
grepfru_it wrote: post #180

Earlier quoted context omitted.

That's because Monster has caffiene and other chemicals in there that may kill you! The Taurine itself probably won't kill you as LD50 is 5g per kg of body weight

LD50 should be taken with a huge grain of salt for any compound. First of all LD50 is just the dose required to kill half the subjects within some short time frame. Long term toxicity is not captured by this number. And doses well below LD50 can still kill you. Also, because you can't overdose humans with drugs until half of them die(in most jurisdictions...), the number is pretty much always based on animal experime…

What’s the LD50 of a huge grain of salt.

While the mouse example of 1000mg/kg is ridiculously high, the monkey trial used 250mg/kg.

Assumption time: assume a 67kg human who consumes 3 cans of redbull a day (not especially unusual). they are ingesting 9000mg (total) per day, which comes out 135mg/kg. Given the easy availability of Taurine supplements in almost any pharmacy it’s not a stretch to see this pushed significantly higher.

Added to the above, this was an initial trial, and it’s very possible the therapeutic levels of Taurine supplementation may be significantly lower (there appeared to be a correlation of health and life extension between the mice and monkeys even with the significant difference in dosages) it’s very possible that the 3 can of red bull dosage is efficacious. Of course that could be mitigated by the high levels of sugar and caffeine but that is outside of the scope of this conversation.

To summarize : 250mg/kg was efficacious in monkeys and no lower bound was determined, it’s possible the amount of Taurine in 3 cans of redbull (assume 9000mg) per day is within the clinically effective range.

Re: Taurine deficiency as a driver of aging

#286

Post by winternewt »

eropple wrote: post #258
winternewt wrote: post #218

Earlier quoted context omitted.

According to GPT4 there's research indicating that taurine increases metabolism, improves athletic performance, helps regulate neurotransmitters (so could be construed to improve cognitive functioning), and improves cardiovascular health. I'd wager you can't conclude from any of that research that putting a gram of it in a drink will help with anything at all, but from a marketing perspective it's a name that carries…

GPT4 is not a search engine. Please stop. Cite sources or don't do this.

I did cite my source by saying it's GPT4, so you know exactly what quality to attribute to the information. I figured it was a good enough source given the context, because my point was that taurine is a good fit for marketing. For that purpose it doesn't really matter whether the information is true. What matters is public perception, and I trust that that's well represented by GPT4 in this case.

Re: Taurine deficiency as a driver of aging

#287

Post by eropple »

winternewt wrote: post #286
eropple wrote: post #258

Earlier quoted context omitted.

GPT4 is not a search engine. Please stop. Cite sources or don't do this.

I did cite my source by saying it's GPT4, so you know exactly what quality to attribute to the information. I figured it was a good enough source given the context, because my point was that taurine is a good fit for marketing. For that purpose it doesn't really matter whether the information is true. What matters is public perception, and I trust that that's well represented by GPT4 in this case.

GPT4 isn't a source of information. It's a probabilistic string of text.

Cite actual sources, please.

Re: Taurine deficiency as a driver of aging

#289

Post by pedalpete »

nradov wrote: post #185
pedalpete wrote: post #132

I'd be curious to know why taurine in blood declines with age? Though supplementation is fine, if the diet stays the same, what is happening in the body that makes it unable use the taurine which is naturally in food. Also, apparently only animal products contain taurine, and vegans have lower levels of taurine. https://veganhealth.org/protein/taurine-and-carnitine/

In general the digestive system becomes less effective at extracting all amino acids as we age. This is why elderly people need to increase their protein intake in order to avoid sarcopenia.

That's interesting. Looks like I'll be spending part of my day looking at how our gut changes with age.

Thanks!

Re: Taurine deficiency as a driver of aging

#290

Post by jaggederest »

BizarroLand wrote: post #282
philipov wrote: post #260

Earlier quoted context omitted.

Maybe there's a benefit to not needing to spend the energy or raw materials needed to synthesize something yourself? The large amounts needed might reflect that outsourcing the production is inefficient.

That makes me wonder how much of the physiological lifecycle we can offload the external processes and how much effect would that have on a human being? We know, for instance, that connecting the circulatory system from an older animal to a younger one will cause the body of the younger animal to spend energy healing the cellular damage of the older one and can cause the older one to become younger by the markers we…

I don't think we'd be permanently attached, in that scenario. It would be more like a dock you attach to at night, or when at home.

Still horrific, don't get me wrong, but much less socially gauche than hauling a backpack full of spare parts around.

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