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Taurine deficiency as a driver of aging

science.org

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Re: Taurine deficiency as a driver of aging

#271

Post by throwaway2037 »

theobromananda wrote: post #261
throwaway2037 wrote: post #198

Earlier quoted context omitted.

By the way: A 16 oz can of Monster contains 2 grams of taurine. My first thought when I reading your post (before I finished): How many grams of taurine per kilogram of body weight were used in the trial? I found: Taurine supplementation increases the life span of mice To determine whether the observed drop in taurine concentration contributes to aging, we orally administered control solution or taurine at 1000 mg pe…

Human-mouse conversion ratio is 1:12.3, so about 6g a day. I easily eat a gram if I drink a ton of coffee.

Thank you to share! Where does that ratio come from? Please educate us.

Re: Taurine deficiency as a driver of aging

#272

Post by tanjtanjtanj »

Blackthorn wrote: post #119
detrites wrote: post #115

Earlier quoted context omitted.

2-3 generations. Historically demonstrable as a metric to be sure about the ill effects of a new substance/tech. History is littered with examples of consumers & industry placing convenience & profits ahead of what's sensible to these ends. Eg, X-rays - 60 years from invention, popularity, child use, "crazy" people claiming they're bad, to suspicion they might be, conservative study, realising they're screwed, all ki…

> I mean, why are people even considering artificial sweeteners? Isn't it only because it's taken us all several decades to realise refined sugar is fucked after initially thinking it was great if not at least "safe"? Can't speak for anyone else obviously, I use sucralose to sweeten plain nonfat greek yogurt for breakfast. It tastes like churned asshole without it, but it's otherwise a great food with everything I ne…

Have you tried allulose/Monk Fruit? That's the new zero calorie sweetener hotness. I've been using it for sweetener the past year and haven't heard of any ill effects but that could just be due to lack of studies like we have for sucralose and erythritol.

Re: Taurine deficiency as a driver of aging

#273

Post by gattilorenz »

anjel wrote: post #181
lo_zamoyski wrote: post #156

Earlier quoted context omitted.

Now do weed.

Genome-wide DNA methylation association study of recent and cumulative marijuana use in middle aged adults https://www.nature.com/articles/s41380-023-02106-y

And in general, if you’re smoking it…

Re: Taurine deficiency as a driver of aging

#274

Post by gattilorenz »

throwaway290 wrote: post #228
gattilorenz wrote: post #89

Earlier quoted context omitted.

Alcohol is a carcinogen, so if you’re optimizing for “living longer” you should take exactly 0 mL a day. If you’re optimizing for living happier, on the other hand…

Oxygen is a carcinogen, now what...

That’s why we recently decided to cut its presence in the atmosphere by dramatically increasing CO2.

But as usual, inhale in small amounts only. There might be a cure coming at some point, but don’t hold your breath.

:^)

Re: Taurine deficiency as a driver of aging

#275

Post by JibberMeTimbers »

diydsp wrote: post #242
briHass wrote: post #192

Earlier quoted context omitted.

> That said, I'd absolutely recommend sugar over many other available sweeteners. I sure wouldn't. Many of the classic, non-nutritive sweeteners like sucralose have been tested more thoroughly than almost any substance we ingest. Even at heroic doses tens of thousands of times higher than what would be used normally, no significant health effects have been noted. In contrast, we have sucrose: a caloric carbohydrate t…

> Many of the classic, non-nutritive sweeteners like sucralose have been tested more thoroughly than almost any substance we ingest. ..until last week: https://duckduckgo.com/?q=sucralose+cancer

Also: https://www.splenda.com/blog/splenda-brand-statement-on-rece...

Re: Taurine deficiency as a driver of aging

#276

Post by insanitybit »

voytec wrote: post #259
insanitybit wrote: post #238

Earlier quoted context omitted.

AFAIK, at this point resveratrol does not look promising.

David Sinclair wrote in "Lifespan"[1] that they extended mice lifespan by (iirc) something like 40% but amounts of resveratrol used was something like mentioned 750-1000 wine glasses daily when translated to humans. While Wikipedia suggests that resveratrol is not proven to help with anything, I'm still taking 600mg in the morning, along with 600mg ALA and 100mg of CoQ10. Placebo is an effect, too. [1] https://en.wik…

https://www.youtube.com/watch?v=vGmmBJq0NNo

I think at this point Sinclair has lost a lot of credibility

Re: Taurine deficiency as a driver of aging

#277

Post by hombre_fatal »

baremetal wrote: post #101
hombre_fatal wrote: post #76

Earlier quoted context omitted.

Reality: At the very highest concentrations of the sucralose compound tested in this study, using cells in petri dishes, one marker of gene damage was slightly elevated

In reality, I try to minimize my exposure to known carcinogens. This one is quite avoidable.

If your epistemic standard is based on what happens to a single marker of cells in a petri dish at concentrated levels of exposure, then the list of foods you should avoid is endless. You couldn't even eat meat nor all sorts of vegetables even though those foods improve human health outcomes in clinical trials.

For example, that experiment can't even capture the most basic hormetic effect.

Re: Taurine deficiency as a driver of aging

#278

Post by dreamcompiler »

throwaway2037 wrote: post #198
robwwilliams wrote: post #133

Solid study, but the core results are based on a single genotype of mouse — C57BL/6J. Imagine a clinical study of longevity using 120 clones of you or me. Taurine may be effective at extending lifespan and healthspan of C57BL/6J mice but will it work as well using genetically diverse mice such as the UM-HET3 mice? Like humans, the UM-HET3 mice are genetically diverse (they segregate for about 11.5 million sequence va…

By the way: A 16 oz can of Monster contains 2 grams of taurine. My first thought when I reading your post (before I finished): How many grams of taurine per kilogram of body weight were used in the trial? I found: Taurine supplementation increases the life span of mice To determine whether the observed drop in taurine concentration contributes to aging, we orally administered control solution or taurine at 1000 mg pe…

Forward-quoting a comment by rale00 below:

"You don't directly convert dosage across species like that. The dosage they tested on monkeys was 250mg/kg, and the human equivalent would be less than that."

Re: Taurine deficiency as a driver of aging

#279

Post by dreamcompiler »

Turing_Machine wrote: post #130
A_D_E_P_T wrote: post #66

Earlier quoted context omitted.

The basic formula from mouse to human is (X mg * (3/37)) = human equivalent dose in mg/kg. In this case (1000mg * 3/37)) comes out to 81mg/kg. So, if you weigh 80kg, it comes out to 6.48 grams per day. That's a lot of taurine, but not really a crazy amount. Easy enough to consume.

I see that Amazon sells 1 gram capsules of taurine (several vendors). So, yeah, not too difficult to consume. One brand I saw is about $0.08/gram, so it wouldn't be overly financially burdensome, either.

IMO anything you buy from Amazon that goes into your body should be considered at best fraudulent and at worst toxic until proven otherwise.

Re: Taurine deficiency as a driver of aging

#280

Post by bluedonuts »

AtlasBarfed wrote: post #202
robwwilliams wrote: post #133

Solid study, but the core results are based on a single genotype of mouse — C57BL/6J. Imagine a clinical study of longevity using 120 clones of you or me. Taurine may be effective at extending lifespan and healthspan of C57BL/6J mice but will it work as well using genetically diverse mice such as the UM-HET3 mice? Like humans, the UM-HET3 mice are genetically diverse (they segregate for about 11.5 million sequence va…

WHy does it have Taurine? I honestly don't know why any of the non-caffiene non-b vitamin ingredients are in "energy drinks" like Taurine.

Taurine is said to have an anti-anxiety effect. I have taken it for this reason and believe it is effective (or placebo ..).

My assumption was it helps ease the stimulant effects of all the other stuff in energy drinks.

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