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Taurine deficiency as a driver of aging

science.org

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Re: Taurine deficiency as a driver of aging

#231

Post by simaltwman »

throwaway2037 wrote: post #198
robwwilliams wrote: post #133

Solid study, but the core results are based on a single genotype of mouse — C57BL/6J. Imagine a clinical study of longevity using 120 clones of you or me. Taurine may be effective at extending lifespan and healthspan of C57BL/6J mice but will it work as well using genetically diverse mice such as the UM-HET3 mice? Like humans, the UM-HET3 mice are genetically diverse (they segregate for about 11.5 million sequence va…

By the way: A 16 oz can of Monster contains 2 grams of taurine. My first thought when I reading your post (before I finished): How many grams of taurine per kilogram of body weight were used in the trial? I found: Taurine supplementation increases the life span of mice To determine whether the observed drop in taurine concentration contributes to aging, we orally administered control solution or taurine at 1000 mg pe…

According to https://examine.com/supplements/taurine/

"Serious adverse effects have not been reported with taurine supplementation. The highest dose used in a human trial was 10 grams per day for 6 months, and the longest human trial was 12 months and used a dose of 0.5–1.5 grams per day. Based on the available evidence, it’s suggested that 3 grams per day can be consumed indefinitely without risk of side effects."

"The observed safety limit, the highest dose for which one can be relatively assured that no side effects will occur over a lifetime, has been suggested to be 3g of taurine in supplemental form (in addition to food intake) a day.[140] Higher doses have been tested and well tolerated, but not enough evidence is available to suggest lifelong safety of said doses.

There is a notion that taurine causes heart damage, which is currently unsupported (and contrary to a fair bit of evidence). This appears to be due to a misunderstanding of why serum taurine levels are elevated during cardiac failure (which is from taurine leakage from cells)."

My advice, however, is to not take it for antiaging until the science is done on humans, specially at high doses.

Re: Taurine deficiency as a driver of aging

#232

Post by HPsquared »

k__ wrote: post #36

They fed mice 1g taurine per 1kg body weight per day. For me that would be 80g per day. 1kg of pure taurine cost 25€ on Amazon. That makes a 1.20€ per day. Sounds okay.

Mice have faster metabolism, so eat more of everything per kg of body weight per day. Square-cube law in action!

Re: Taurine deficiency as a driver of aging

#233

Post by dsign »

As a PhD and a hobby writer myself, I tend to put a lot of attention on first sentences. And it is something that all academics do, specially when submitting to the highest divinities, i.e. Science and Nature.

The first sentence in the structured abstract of this paper is curious:

> Aging is an inevitable multifactorial process.

If the paper were discussing aging in general, the use of the word "inevitable" would be an expected adjective. Not entirely useful, it wouldn't be new information because everybody knows that aging is inevitable, but excusable.

Yet, the paper is discussing counteracting--if only a little--aging. I would have written "Aging is a poorly understood multifactorial process" (to be modest), or "Aging is the combination of natural drift and degradation in complex systems and evolved coping mechanisms" (to set the world on fire).

So, to me, this first sentence sounds like cultural subservience: "Before you get the pitchforks and the bonfires, we don't want to be young forever, please spare us. Now, with that out of the way, aging is a multifactorial..."

Re: Taurine deficiency as a driver of aging

#234

Post by bartislartfast »

jaggederest wrote: post #209
throwaway2037 wrote: post #198

Earlier quoted context omitted.

By the way: A 16 oz can of Monster contains 2 grams of taurine. My first thought when I reading your post (before I finished): How many grams of taurine per kilogram of body weight were used in the trial? I found: Taurine supplementation increases the life span of mice To determine whether the observed drop in taurine concentration contributes to aging, we orally administered control solution or taurine at 1000 mg pe…

Standard intake of taurine in most people is <200mg a day. That would be an astounding amount of taurine. Also, it's a little weird because humans can synthesize taurine, it's a major component of bile, so I'm unclear what mechanism could cause supplementation to have significant effects.

> humans can synthesize taurine, it's a major component of bile, so I'm unclear what mechanism could cause supplementation to have significant effects.

If the amount we synthesize drops over time then supplementing that would be beneficial?

I'm sure there are parallels in other things the body synthesizes

Re: Taurine deficiency as a driver of aging

#235

Post by bartislartfast »

robwwilliams wrote: post #133

Solid study, but the core results are based on a single genotype of mouse — C57BL/6J. Imagine a clinical study of longevity using 120 clones of you or me. Taurine may be effective at extending lifespan and healthspan of C57BL/6J mice but will it work as well using genetically diverse mice such as the UM-HET3 mice? Like humans, the UM-HET3 mice are genetically diverse (they segregate for about 11.5 million sequence va…

please let us not all start chugging Monster to live longer. 2 grams of taurine will surely be nullified by all the other crap in there

Re: Taurine deficiency as a driver of aging

#236

Post by YawningAngel »

jaggederest wrote: post #209
throwaway2037 wrote: post #198

Earlier quoted context omitted.

By the way: A 16 oz can of Monster contains 2 grams of taurine. My first thought when I reading your post (before I finished): How many grams of taurine per kilogram of body weight were used in the trial? I found: Taurine supplementation increases the life span of mice To determine whether the observed drop in taurine concentration contributes to aging, we orally administered control solution or taurine at 1000 mg pe…

Standard intake of taurine in most people is <200mg a day. That would be an astounding amount of taurine. Also, it's a little weird because humans can synthesize taurine, it's a major component of bile, so I'm unclear what mechanism could cause supplementation to have significant effects.

Humans can synthesise creatine, but we synthesise less than is ideal for elite strength athletes, so supplementation is still effective

Re: Taurine deficiency as a driver of aging

#238

Post by insanitybit »

voytec wrote: post #61
redkinght99 wrote: post #8

Taurine? I've been jacking myself full of that since Middle School! Thanks RedBull! Jokes aside, This feels like one of "Wine is Good for you " In moderation and other fine point details. Not buying it.

> Jokes aside, This feels like one of "Wine is Good for you" In moderation and other fine point details. Not buying it. I mean, pinot noir has a lot of resveratrol. You'd just need 750-1000 glasses daily.

AFAIK, at this point resveratrol does not look promising.

Re: Taurine deficiency as a driver of aging

#239

Post by insanitybit »

raylad wrote: post #214
ggm wrote: post #190

If you're old, Eat more protein. Anyone doing any degree of attempt to recover (lost) muscle tone as an older person is told 'eat more protein' to help "feed" muscle mass rebuilding after the exercise induced stresses which are heading to "bigger muscles" So if you eat more protein, you're going to get Taurine. Drinking a can of "monster" is not the answer. Does this mean "exercise extends life" is actually .. the pr…

This actually may not be good advice, because methionine restriction has been found to mimic caloric restriction in extending lifespan, and also inhibits cancer cell growth. See: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5008916/ and https://pubmed.ncbi.nlm.nih.gov/32138282/ for example.

Go for pea protein then?

Re: Taurine deficiency as a driver of aging

#240

Post by DebtDeflation »

throwaway2037 wrote: post #198
robwwilliams wrote: post #133

Solid study, but the core results are based on a single genotype of mouse — C57BL/6J. Imagine a clinical study of longevity using 120 clones of you or me. Taurine may be effective at extending lifespan and healthspan of C57BL/6J mice but will it work as well using genetically diverse mice such as the UM-HET3 mice? Like humans, the UM-HET3 mice are genetically diverse (they segregate for about 11.5 million sequence va…

By the way: A 16 oz can of Monster contains 2 grams of taurine. My first thought when I reading your post (before I finished): How many grams of taurine per kilogram of body weight were used in the trial? I found: Taurine supplementation increases the life span of mice To determine whether the observed drop in taurine concentration contributes to aging, we orally administered control solution or taurine at 1000 mg pe…

>1000 mg per kg body weight

1g/kg body weight daily of ANYTHING is A LOT. 0.1% of your entire bodyweight.

What's interesting is I checked Wikipedia and found:

https://en.wikipedia.org/wiki/Taurine

>accounts for up to 0.1% of total human body weight

>The mean daily intake from omnivore diets was determined to be around 58 mg

So this study is adding the entire amount found in a typical human's bodyweight every day.

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