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Taurine deficiency as a driver of aging

science.org

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Re: Taurine deficiency as a driver of aging

#211

Post by [deleted] »

chasil wrote: post #199
ggm wrote: post #190

If you're old, Eat more protein. Anyone doing any degree of attempt to recover (lost) muscle tone as an older person is told 'eat more protein' to help "feed" muscle mass rebuilding after the exercise induced stresses which are heading to "bigger muscles" So if you eat more protein, you're going to get Taurine. Drinking a can of "monster" is not the answer. Does this mean "exercise extends life" is actually .. the pr…

Would it be more practical to take a supplement containing all the amino acids used by [human] ribosomes? Those, as I understand them to be, are: alanine, arginine, asparagine, aspartic acid, cysteine, glutamine, glutamic acid, glycine, histidine, isoleucine, leucine, lysine, methionine, phenylalanine, proline, serine, threonine, tryptophan, tyrosine, valine. And why am I not seeing taurine in this list? https://www.…

[deleted]

Re: Taurine deficiency as a driver of aging

#212

Post by [deleted] »

ggm wrote: post #190

If you're old, Eat more protein. Anyone doing any degree of attempt to recover (lost) muscle tone as an older person is told 'eat more protein' to help "feed" muscle mass rebuilding after the exercise induced stresses which are heading to "bigger muscles" So if you eat more protein, you're going to get Taurine. Drinking a can of "monster" is not the answer. Does this mean "exercise extends life" is actually .. the pr…

[deleted]

Re: Taurine deficiency as a driver of aging

#213

Post by LouisSayers »

udkl wrote: post #142
crtified wrote: post #141

Earlier quoted context omitted.

Be sure to rule out the 'sugar rush' effect. Not that your ~150 millilitre (or just over 5 fl oz) drink is the world's worst in that respect - it weighs in at around 4 teaspoons of sugar, based upon my googling. Some energy drinks have more. It's still the sugar equivalent of having a small cup of tea/coffee/water, and stirring in 4 sugars. If chugged down quickly, that's quite a hit! Even if not, it's still more sug…

It was a sugar-free monster. Drinking or eating other sugar rich products do not have the effect.

I'm not sure what your original post said, but more a response to the other commentor on "chugging down quickly".

Note that energy drinks have caffeine, and if you consume a lot of caffeine in a short time it can be fatal.

For anyone wanting to consume taurine, you can simply buy taurine. No need to drink energy drinks which I'm sure aren't super healthy (even without sugar).

Re: Taurine deficiency as a driver of aging

#214

Post by raylad »

ggm wrote: post #190

If you're old, Eat more protein. Anyone doing any degree of attempt to recover (lost) muscle tone as an older person is told 'eat more protein' to help "feed" muscle mass rebuilding after the exercise induced stresses which are heading to "bigger muscles" So if you eat more protein, you're going to get Taurine. Drinking a can of "monster" is not the answer. Does this mean "exercise extends life" is actually .. the pr…

This actually may not be good advice, because methionine restriction has been found to mimic caloric restriction in extending lifespan, and also inhibits cancer cell growth.

See: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5008916/ and https://pubmed.ncbi.nlm.nih.gov/32138282/ for example.

Re: Taurine deficiency as a driver of aging

#215

Post by az226 »

redkinght99 wrote: post #8

Taurine? I've been jacking myself full of that since Middle School! Thanks RedBull! Jokes aside, This feels like one of "Wine is Good for you " In moderation and other fine point details. Not buying it.

Unfortunately all the sugar is working in the opposite direction.

Re: Taurine deficiency as a driver of aging

#216

Post by robocat »

throwaway2037 wrote: post #198
robwwilliams wrote: post #133

Solid study, but the core results are based on a single genotype of mouse — C57BL/6J. Imagine a clinical study of longevity using 120 clones of you or me. Taurine may be effective at extending lifespan and healthspan of C57BL/6J mice but will it work as well using genetically diverse mice such as the UM-HET3 mice? Like humans, the UM-HET3 mice are genetically diverse (they segregate for about 11.5 million sequence va…

By the way: A 16 oz can of Monster contains 2 grams of taurine. My first thought when I reading your post (before I finished): How many grams of taurine per kilogram of body weight were used in the trial? I found: Taurine supplementation increases the life span of mice To determine whether the observed drop in taurine concentration contributes to aging, we orally administered control solution or taurine at 1000 mg pe…

> taurine at 1000 mg per kg body weight

Another commenter mentioned that taurine “LD50 is [5000 mg] per kg of body weight”.

So you would want to be very careful - especially if you are old, on medicine, drink alcohol, or have any issues processing taurine (liver/kidney?).

Re: Taurine deficiency as a driver of aging

#217

Post by kdamica »

linsomniac wrote: post #189
robwwilliams wrote: post #133

Solid study, but the core results are based on a single genotype of mouse — C57BL/6J. Imagine a clinical study of longevity using 120 clones of you or me. Taurine may be effective at extending lifespan and healthspan of C57BL/6J mice but will it work as well using genetically diverse mice such as the UM-HET3 mice? Like humans, the UM-HET3 mice are genetically diverse (they segregate for about 11.5 million sequence va…

Didn't read the study, but would it be good if they had 120 clones of you and gave 60 taurine and 60 a placebo, and the taurine ones showed better longevity?

Yes, it would be good and this is precisely what they did in this study.

Re: Taurine deficiency as a driver of aging

#218

Post by winternewt »

AtlasBarfed wrote: post #202
robwwilliams wrote: post #133

Solid study, but the core results are based on a single genotype of mouse — C57BL/6J. Imagine a clinical study of longevity using 120 clones of you or me. Taurine may be effective at extending lifespan and healthspan of C57BL/6J mice but will it work as well using genetically diverse mice such as the UM-HET3 mice? Like humans, the UM-HET3 mice are genetically diverse (they segregate for about 11.5 million sequence va…

WHy does it have Taurine? I honestly don't know why any of the non-caffiene non-b vitamin ingredients are in "energy drinks" like Taurine.

According to GPT4 there's research indicating that taurine increases metabolism, improves athletic performance, helps regulate neurotransmitters (so could be construed to improve cognitive functioning), and improves cardiovascular health.

I'd wager you can't conclude from any of that research that putting a gram of it in a drink will help with anything at all, but from a marketing perspective it's a name that carries all the right connotations.

Re: Taurine deficiency as a driver of aging

#220

Post by fasteo »

pkoird wrote: post #177
fasteo wrote: post #53

Any nutrient deficiency is usually a proxy for a poor diet, or at least a diet lacking some key foods. For taurine, it would be some animal food source, specially molusk/fish.

Or digestive disorders like IBD

Agree, but in that case oral supplementation won't help
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