Hacker News Board Hacker News, browsed like a classic message board
Live data from Hacker News

Taurine deficiency as a driver of aging

science.org

Post reply on HN
Print view View original

241–250 of 301 posts

Re: Taurine deficiency as a driver of aging

#241

Post by diydsp »

robocat wrote: post #216
throwaway2037 wrote: post #198

Earlier quoted context omitted.

By the way: A 16 oz can of Monster contains 2 grams of taurine. My first thought when I reading your post (before I finished): How many grams of taurine per kilogram of body weight were used in the trial? I found: Taurine supplementation increases the life span of mice To determine whether the observed drop in taurine concentration contributes to aging, we orally administered control solution or taurine at 1000 mg pe…

> taurine at 1000 mg per kg body weight Another commenter mentioned that taurine “LD50 is [5000 mg] per kg of body weight”. So you would want to be very careful - especially if you are old, on medicine, drink alcohol, or have any issues processing taurine (liver/kidney?).

Ok. As im approaching my first half-kilo, my 250th can of energy drink, i'll slow down.

Re: Taurine deficiency as a driver of aging

#242

Post by diydsp »

briHass wrote: post #192
tiffanyg wrote: post #173

Earlier quoted context omitted.

> By the way: A 16 oz can of Monster contains 2 grams of taurine. And at least 50%+ of the "added sugar" recommendation(s) for an entire day (depending on whether you look at FDA, AHA, etc. guidelines). You make good points, for sure, and I appreciate your comment and insights. But, "sugar" is definitely an issue with a lot of current foods. Carbohydrates are crucial building blocks, biochemically. However, there are…

> That said, I'd absolutely recommend sugar over many other available sweeteners. I sure wouldn't. Many of the classic, non-nutritive sweeteners like sucralose have been tested more thoroughly than almost any substance we ingest. Even at heroic doses tens of thousands of times higher than what would be used normally, no significant health effects have been noted. In contrast, we have sucrose: a caloric carbohydrate t…

> Many of the classic, non-nutritive sweeteners like sucralose have been tested more thoroughly than almost any substance we ingest.

..until last week:

https://duckduckgo.com/?q=sucralose+cancer

Re: Taurine deficiency as a driver of aging

#244

Post by throwaway290 »

Blackthorn wrote: post #62
snapcaster wrote: post #39

Earlier quoted context omitted.

You don't know this! I don't take issue with you consuming it but you absolutely shouldn't have confidence that there aren't negative effects from consuming something humans never had to adapt to. Just say "we don't know of anything wrong with consuming it"

These artificial sweeteners are among the most studied chemicals in the world. At some point you've gotta say okay, they're fine, or okay, they're not.

If artificial sweeteners are so well studied as you claim then why sucralose was found to damage DNA while erythritol was linked to heart attacks in studies just this year?

Sugar or nothing for me personally.

Re: Taurine deficiency as a driver of aging

#245

Post by mtlmtlmtlmtl »

grepfru_it wrote: post #180
insaider wrote: post #176

Earlier quoted context omitted.

Whats your thoughts on the dosage? They use 1g per kg of body weight! If I drank Monster to get the equivalent dosage I think I'd probably die... How did they arrive on that dosage?

That's because Monster has caffiene and other chemicals in there that may kill you! The Taurine itself probably won't kill you as LD50 is 5g per kg of body weight

LD50 should be taken with a huge grain of salt for any compound. First of all LD50 is just the dose required to kill half the subjects within some short time frame. Long term toxicity is not captured by this number. And doses well below LD50 can still kill you.

Also, because you can't overdose humans with drugs until half of them die(in most jurisdictions...), the number is pretty much always based on animal experiments. And it's quite typical for some things to be wildly more toxic in certain species than in others.

Crucially, a dose of 1g/kg has never been tested in humans in the short or long term.

I'd be very hesitant to say that 1g/kg is unlikely to kill a human being based on LD50 being 5g/kg. It could very well have an unacceptably high risk of death, or long term toxicity.

Also, please don't make statements like this based on LD50 unless you're absolutely sure. Someone who understands even less about it might look at it and thnk "this guy seems to know his stuff", and then do something stupid.

Re: Taurine deficiency as a driver of aging

#246

Post by heresie-dabord »

dsign wrote: post #233

As a PhD and a hobby writer myself, I tend to put a lot of attention on first sentences. And it is something that all academics do, specially when submitting to the highest divinities, i.e. Science and Nature. The first sentence in the structured abstract of this paper is curious: > Aging is an inevitable multifactorial process. If the paper were discussing aging in general, the use of the word "inevitable" would be…

> cultural subservience

Or perhaps recognition that we live in the time of a Fallacy-Industrial Complex?

"Aging is inevitable, there is no magic, don't delude yourself into thinking that you are going to avoid aging by gorging on some single element or compound. Get enough rest, take care of your teeth and gums, exercise daily, and maintain a healthy weight. Everything else is a marketing scam.

That said, here's what we found playing with mice and taurine..."

Re: Taurine deficiency as a driver of aging

#247

Post by majkinetor »

paulryanrogers wrote: post #145
majkinetor wrote: post #129

Earlier quoted context omitted.

There is no such thing as 0 tollerance. Don't believe the anti-alcohol hype. There is such thing as hormesis, for basically any poison.

Evidence for hormesis is not convincing.

That is not true. Hormesis is a fact.

Re: Taurine deficiency as a driver of aging

#248

Post by robocat »

diydsp wrote: post #241
robocat wrote: post #216

Earlier quoted context omitted.

> taurine at 1000 mg per kg body weight Another commenter mentioned that taurine “LD50 is [5000 mg] per kg of body weight”. So you would want to be very careful - especially if you are old, on medicine, drink alcohol, or have any issues processing taurine (liver/kidney?).

Ok. As im approaching my first half-kilo, my 250th can of energy drink, i'll slow down.

500g of taurine for a 100kg person - 50% chance you will be slowed down permanently (LD50 == Lethal Dose 50% - 1 in 2 chance of death).

Re: Taurine deficiency as a driver of aging

#249

Post by salad-tycoon »

andy_ppp wrote: post #164

I order stuff off the Internet from time to time including taurine, is there an easy/cheap way to test things that come through the post from Amazon or another company are Taurine and don’t contain things they shouldn’t? The supplement industry strikes me as dubious! Is there a better way to think about this?

I’ve been considering the same. I think, first off, Amazon is absolutely the worst place to buy supplements due to potential fakes.

I’ve seen consumer labs.com has done some independent 3rd party testing but it’s not on everything.

There are nootropic outfits that will send you the COA on request. Obviously, who knows what that piece of paper is worth. They could have bought a clean report or could have done a bait and switch.

For my part I research user reviews before I buy something . If a company has been caught lying in the past, I avoid them. No affiliation, I’ve found nootropics depot and lift mode to be well regarded in the Ethernet, generally.Also, Thorne, cellcor, life extension. But again this doesn’t solve the problem of trust. Strangely a lot of internet denizens have a loyalty of their suppliers and typically users report just on what they perceive to be effects and physical properties of supplements received. I also give some weight to anabolic steroid forums. Think what you want about them but the meatheads are real citizen scientists in the realm of chemical ingestion and prone to distrust (and astroturfing on the flip side).

I think some of the smaller companies just buy things off of places like Ali baba. Larger companies still source a ton of their stuff from China. The better smaller companies make an attempt to be transparent with COA, the larger ones just work off their name recognition.

This lack of trust of Chinese consumables extends far beyond just supplements and even the honey industry is implicated in fake products. Recall chinas baby formula fiasco a while back or that they made aquadots out of GHB or the toxic paint they use on toys. Etc. Plenty of reasons for distrust of drop shipped or sourcing from overseas/China.

It’s the Wild West out there in the supplement world and even worse in the “research chemical” peptide world.

I wish we could have a crowd sourced funding for 3rd party testing.

Re: Taurine deficiency as a driver of aging

#250

Post by salad-tycoon »

objektif wrote: post #163

Would taking supplements work as well? I saw that Taurine supplements are available for cheap. I have no idea what people are taking it for.

Heart health/CHF, physical performance, mood ( seems to “even out” effects from caffeine), liver function/hepatitis.
Post reply on HN