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Ozempic drug supresses desire to smoke, drink and more?

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Re: Ozempic drug supresses desire to smoke, drink and more?

#261

Post by SystemOut »

justinclift wrote: post #206
SystemOut wrote: post #183

Earlier quoted context omitted.

My story / anecdata. About 6 months ago there was a posting about Ozempic and I had said something to the effect that it wasn't worth it watching some of the side effects my wife had from it. And then I went to the doctor for a check-up and lo and behold I had diabetes. Asymptomatic, but an A1C of 11. My doctor re-ran the test because he didn't believe it and it doesn't run in my family. My cholesterol had also jumpe…

Out of curiosity, do you drink much water each day? I'm kind of wondering if the people having a bad result don't drink enough water each day to clear out their systems? Yeah, that's a simplistic take... but still, curiosity. :)

Yeah, most of the time I think I do. I suspect it has to do more with diet and maybe water as well. Since Ozempic slows down your digestive process my current thought is that fiber / gut bacteria might have more affect on things but I haven't done a food diary to try and track what impacts me more.

Re: Ozempic drug supresses desire to smoke, drink and more?

#262

Post by tysam_and »

usernew wrote: post #258
jmpman wrote: post #151

I’ve been on Mounjaro since August. Down almost 60lbs, and it’s been a life changer. Have I had some gastrointestinal issues, sure, but expected. I feel great and my brain seems to be functioning as well as when I was in my 20’s. Now, when I go to the bar with friends, I end up having maybe 2 beers and although enjoyable, I don’t feel that light switch turning on which encourages me to drink more. Can I force myself…

If you're interested - not pushing an agenda. Here's what worked for this weird dude to not drink and stay fit. I used to lift and be real fit till about 40. Like bulky-lean looking, bench 400 10x with a 6pack. Had a lot to do with being on the road for work all over the world, and you sit at the gym at the hotel for an hour every night because of nothing else to do, and there are girls there also on business who you…

That last line does not belong on most respectable websites on the internet.

Re: Ozempic drug supresses desire to smoke, drink and more?

#263

Post by reaperman »

remote_phone wrote: post #216
jmpman wrote: post #151

I’ve been on Mounjaro since August. Down almost 60lbs, and it’s been a life changer. Have I had some gastrointestinal issues, sure, but expected. I feel great and my brain seems to be functioning as well as when I was in my 20’s. Now, when I go to the bar with friends, I end up having maybe 2 beers and although enjoyable, I don’t feel that light switch turning on which encourages me to drink more. Can I force myself…

I heard that 2/3 of the weight loss is muscle, do you find that to be the case?

In an actual study of this with published results on clinicaltrials.gov …

Semaglutide users lost 16% bodyweight overall but only 3.4% of their lean mass.

This is study NCT03548935 if you’d like to look it up, there are other statistics of interest in it as well.

Re: Ozempic drug supresses desire to smoke, drink and more?

#264

Post by hayst4ck »

trasz4 wrote: post #20
tboyd47 wrote: post #4

[flagged]

One works, the other doesn't.

Ivermectin did feasibly improve covid outcomes, but only in places where worms were common, which is not the US.

So it's true that people like the one you are responding to are ignorant and can't really understand nuance and that they are also wrong for their lack of trust in institutions, but institutions also failed to communicate to those ignorant people and that is a problem all of it's own.

Very fun science read that I hope humbles you a little:

https://astralcodexten.substack.com/p/ivermectin-much-more-t...

Re: Ozempic drug supresses desire to smoke, drink and more?

#265

Post by piyh »

Jun8 wrote: post #178

So, instead is suppressing the desire to eat, how about inventing a drug that blocks the absorption or breakdown of carbohydrates in the gut? Or maybe control the gut biome so that growth of bacteria that breaks down high calorie food is minimized. Is this faster-than-light-like impossible daydream or is there any plausible path to it?

I don't know about you but I don't want to be shitting loaves of bread everyday

Re: Ozempic drug supresses desire to smoke, drink and more?

#266

Post by crooked-v »

hayst4ck wrote: post #233
MandieD wrote: post #57

Earlier quoted context omitted.

Your relative’s sad story reminds me of a short story I read a few years ago about a miracle pill that leaves about 90% of its takers perfectly slim and able to stay that way eating anything, after a few truly disgusting initial days of elimination, but kills the other 10% gruesomely. Because it’s so wonderfully effective for the majority, there ends up being a ton of social and economic pressure for anyone even slig…

I have to admit, I would probably have taken the pill depending on how gruesome (or mitigatible) the death is. I've been obese and I've been thin, and life is not worth living when obese. 10 years ago, I was reading about nootropics and ran across an interesting piece on the ethics of drugs (that has probably been lost to time). The question it was asking was "why can we take drugs to bring us to normal, but we can't…

> why can we take drugs to bring us to normal, but we can't take drugs that make us better than normal?

Consider caffeine, which is probably entirely responsible by itself for a significant sliver of the world's total GDP.

We just don't have a lot of drugs like that because it's hard to find stuff that's performance-enhancing without serious side effects.

Re: Ozempic drug supresses desire to smoke, drink and more?

#267

Post by Aloha »

mrcrumb1 wrote: post #188
armchairhacker wrote: post #127

Earlier quoted context omitted.

Moralizing about weight loss is upsetting, as someone whose thankfully considers themselves "naturally thin". It's 100% true the vast majority (including me) needs to put some discipline into eating and exercise: normal people can't just eat whatever they want whenever they feel hungry. But normal people don't get fat eating whole foods, working out, eating below their demographic's daily intake; and normal people do…

I'm a person who has vacillated between being close to normal weight and obese. I think people who don't have problems controlling their diet tend to underestimate just how hard it can be to eat at a calorie deficit or even just maintenance when you've lost a large amount of weight. When I'm at my lowest weight I literally am thinking about food constantly and my maintenance calorie intake drops to about 1500-1800 ca…

It's really hard to explain to someone the agony of being hungry all the time - without experiencing it, they just cant understand.

Re: Ozempic drug supresses desire to smoke, drink and more?

#268

Post by reaperman »

yieldcrv wrote: post #170
jmpman wrote: post #151

I’ve been on Mounjaro since August. Down almost 60lbs, and it’s been a life changer. Have I had some gastrointestinal issues, sure, but expected. I feel great and my brain seems to be functioning as well as when I was in my 20’s. Now, when I go to the bar with friends, I end up having maybe 2 beers and although enjoyable, I don’t feel that light switch turning on which encourages me to drink more. Can I force myself…

the most surprising thing to me is how you’re describing normal behavior that I can relate to all my life, but the community of strugglers is so big that this is a whole testimonial people feel comfortable and exalted to share like thats not something I’m deriding its just news to me makes me wonder what this drug actually does, flush gut bacteria? just the right ones?

Any effects on gut bacteria will be very downstream of its primary effects, which are on:

- GLP-1 (semaglutide)

- optionally, that and also GIP (tirzepatide)

- optionally, both of those and also glucagon receptor (retatrutide)

But these hormones directly make you not hungry, among other things. They are probably some of the things that your gut bacteria manipulate to commandeer your behavior.

Re: Ozempic drug supresses desire to smoke, drink and more?

#269

Post by sergiomattei »

AtlasBarfed wrote: post #159
LazyMans wrote: post #155

Yes. On a compounded semaglutide. I can finally control my hunger and a nice unexpected effect has been losing a desire to drink large quantities of alcohol. I don’t drink during the week anyway, but it seems to be the volume that turns me off to drinking. Thus a few cocktails are all I can tolerate. For context, Im 30, male, would be defined as a binge drinker on weekends. Oh, and I’ve given up nicotine entirely. I…

I'd hazard a guess that nicotine is one of the two or three most addictive substances known to humanity. Opiates/heroin is probably worse, world of warcraft is probably third :-) The drug probably helped.

Factorio is third.
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