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New insights into why aspirin works so well

eurekalert.org

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Re: New insights into why aspirin works so well

#111

Post by News-Dog »

coldtea wrote: post #98
ahonhn wrote: post #26

Earlier quoted context omitted.

Its been years since I've seen any bottles or packs of full dose Aspirin in a pharmacy here (Singapore). Seems like nowadays you can only get those low-dose tablets for blood thinning and they cost a fortune (compared to generic Panadol or what normal Aspirin used to cost)

Note that Aspirin is just a brand's name, and you could find the same thing under different names in different markets. E.g. Panadol Extra is the same thing.

NSAIDs : https://news.ycombinator.com/item?id=35311721

Non-Steroidal Anti-Inflammatory Drugs (NSAID) : https://en.wikipedia.org/wiki/NSAIDs

  'NSAIDs and Gastrointestinal (GI) Injury'
https://scholar.google.com/scholar?&q='NSAIDs and Gastrointe...>

Proton Pump Inhibitors (PPIs) : https://en.wikipedia.org/wiki/Proton-pump_inhibitor

List of Proton Pump Inhibitors - Uses, Side Effects : https://www.drugs.com/drug-class/proton-pump-inhibitors.html

----

Acetaminophen : https://news.ycombinator.com/item?id=35310951

N-acetyl-para-aminophenol (APAP), Acetaminophen, Tylenol, Paracetamol, Panadol, others : https://en.wikipedia.org/wiki/Acetaminophen

  'Acetaminophen and Alcohol Hepatotoxicity, Liver damage'
https://scholar.google.com/scholar?&q='Acetaminophen and Alc...>

----

  'P450 Drug Interactions'
Cytochrome P450 : https://en.wikipedia.org/wiki/P450

List of Cytochrome P450 Modulators : https://en.wikipedia.org/wiki/List_of_cytochrome_P450_modula...

Re: New insights into why aspirin works so well

#113

Post by qsi »

coldtea wrote: post #98
ahonhn wrote: post #26

Earlier quoted context omitted.

Its been years since I've seen any bottles or packs of full dose Aspirin in a pharmacy here (Singapore). Seems like nowadays you can only get those low-dose tablets for blood thinning and they cost a fortune (compared to generic Panadol or what normal Aspirin used to cost)

Note that Aspirin is just a brand's name, and you could find the same thing under different names in different markets. E.g. Panadol Extra is the same thing.

Panadol Extra is paracetamol with caffeine, not acetylsalicylic acid, which is Aspirin.

Re: New insights into why aspirin works so well

#114

Post by robbiep »

seiteamoebe wrote: post #112

I remember an old interview with Milton Friedman where he stated using aspirin every other day to reduce the dangers of heart attacks. My grandfather did the same. So I guess this wasn’t such a good idea after all?

no it is still a mainstay of treatment for those at high risk

Re: New insights into why aspirin works so well

#115

Post by [deleted] »

seattle_spring wrote: post #55
jamal-kumar wrote: post #25

Earlier quoted context omitted.

There's something like a downward spiral into hell that is opiates which starts with low doses like what you're on and escalates into worse and worse bullshit because you're not even trying to treat the underlying inflammation before masking the pain with opiates, and then the movement the pain is trying to prevent you from doing happens anyways and you just end up with more damage. I'm telling you these alternatives…

"just try weed bro" is the absolute worst most condescending advice you can give to someone suffering from chronic pain who didn't ask for advice. Do you really, really think someone just "went to opiates" before trying absolutely everything to identify and treat the underlying cause?

[deleted]

Re: New insights into why aspirin works so well

#117

Post by robbiep »

zabzonk wrote: post #8

annecdata: aspirin is pretty good as an anti-inflamitory and hence pain-killer. the reason i don't take it is that it irritates the stomach, and i have enough issues with my insides as it is (irritable-bowel syndrome - not fun) i currently use cocodamol (codeine and paracetomol) to control my arthritic pain, but it isn't doing so great. at the end of the day, if you really need pain control, you probably want a pure…

1 in 6 caucasians don't metabolise codeine to any useful form and therefore derive zero benefit from it. Opiates are never a good lifestyle option for chronic pain.

Re: New insights into why aspirin works so well

#118

Post by archerx »

seattle_spring wrote: post #80
imwillofficial wrote: post #77

Earlier quoted context omitted.

That’s not what this site is about. Here every lane is our lane. It’s how we grow.

This site is about spreading false and misleading information under the guise of "just giving helpful advice"? Thanks but I'll continue to call out dangerous misinformation when I see it. Let's keep "reefer madness, but for pain medicine" at the fringes.

[flagged]

Re: New insights into why aspirin works so well

#119

Post by znpy »

seiteamoebe wrote: post #112

I remember an old interview with Milton Friedman where he stated using aspirin every other day to reduce the dangers of heart attacks. My grandfather did the same. So I guess this wasn’t such a good idea after all?

my father in law (76 years old) does the same, but it's not the same kind of aspirin i'd take.

Iirc there's a special version for that use. I think it's called cardio-aspirin or something?

The downside is that it's an anti-coagulant, so if you bleed for any reason it will not stop bleeding as easily as without the cardio-aspirin.

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