New insights into why aspirin works so well

I've always though Aspirin was a deprecated drug but lately I've heard reports from people who claim it's the only thing that helps their arthritis or other issues. Maybe there is something behind it.

This paper from 2005 suggests the same: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1809338/

They are very safe when taken as prescribed but quite dangerous when you don't read the directions.

Although IIRC taking fever reducers when sick significantly increases how long it takes to recover. Those fevers are there for a reason.

annecdata:

aspirin is pretty good as an anti-inflamitory and hence pain-killer. the reason i don't take it is that it irritates the stomach, and i have enough issues with my insides as it is (irritable-bowel syndrome - not fun)

i currently use cocodamol (codeine and paracetomol) to control my arthritic pain, but it isn't doing so great. at the end of the day, if you really need pain control, you probably want a pure opioid of some kind. and yes, i do know that codeine is an opioid.

I love to see some info like this and want to share my experiences.

I'm a fan of small-molecule, well-tolerated, out-of-patent (cheap), widely available pharms like this in the class of "maintenance" and "enhancement" rather than "acute therapy" (although there is cross-over: i.e, have an acute headache? aspirin helps).

Some things in my list right now: acetylcysteine, aspirin, metformin

Besides aspirin, I don't take these regularly. And these days I take aspirin less and less, because I found I don't need it any more and I built up a healthy routine anyway.

In general I think eating right (lots of vegetables), good microbiome, plant medicine (for example turmeric (with milk and black pepper) black seed / nigella sativa as seeds or oil), and exercise are better than pharmaceuticals for general enhancement and maintenance of health--but there are some really good pharmaceuticals.

Everyone's body is different to some extent tho, and bodies change over time (for eg, gene expression changes over time), so what works for you might change over time.

This isn't medical advice, consult your doc, but here's other things I think a worth a shot (worked for me in the past) in limited doses:

piracetam - for building new brain cells, and increasing oxygen and decreasing blood viscosity

pentoxifylline - for de-aging your vascular system

fexofenadine - great for me for pollen allergies, and generalized severe inflammation (ie, say you had a really stressful thing)

doxycycline - good antibiotic in small dose but can have some weird side effects in some people, or if taken for long time, but strangely it also help with tissue repair.

fluorometholone - great in eye drop for itchy eyes, also instantly reduces brain inflammation / headache, and chills you out--for me at least--after dropping a couple drops in each eye--but use sparingly as it's a strong corticosteroid so you don't want to dampen the immune system in your sinuses etc as that will lead to infection!

In general I have the view that all pharams and most plant medicines are "toxins" (on some level, at some dose obviously, but in general too) in the sense that there's very few things which are just uniformly healthy in the class of drugs--yet nevertheless there are some wonder drugs like these that I think can be really enhancing to health if used right.

After a couple years taking aspirin at low dose regularly, I started noticing I no longer needed it. That coincided with me adopting a regular meditation/energy work/ some yoga practice.

Currently on my to-try list is: ashwagandha

Please exercise caution in your exploring -- some of what works for me might even be dangerous for you--everyone is different!! :) ;p xx ;p