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New insights into why aspirin works so well

eurekalert.org

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Re: New insights into why aspirin works so well

#51

Post by paganel »

ahonhn wrote: post #26
coldtea wrote: post #5

Earlier quoted context omitted.

Aspirin deprecated? It's one of the most useful and most widespread in use drug on the planet - for far more than "arthritis". It's the WD-40 of drugs. Ah, it's even in TFA: "Aspirin, which is a nonsteroidal anti-inflammatory drug, is one of the most widely used medications in the world. It is used to treat pain, fever and inflammation, and an estimated 29 million people in the U.S. take it daily to reduce the risk o…

Its been years since I've seen any bottles or packs of full dose Aspirin in a pharmacy here (Singapore). Seems like nowadays you can only get those low-dose tablets for blood thinning and they cost a fortune (compared to generic Panadol or what normal Aspirin used to cost)

Here in Romania I always have aspirin at hand.

I take a pill of ibuprofen every once in a while when I have a bad headache, and paracetamol-based drugs only as a last resort when I have a bad cold or similar.

Re: New insights into why aspirin works so well

#52

Post by bigsparky »

DoreenMichele wrote: post #28
jamal-kumar wrote: post #25

Earlier quoted context omitted.

There's something like a downward spiral into hell that is opiates which starts with low doses like what you're on and escalates into worse and worse bullshit because you're not even trying to treat the underlying inflammation before masking the pain with opiates, and then the movement the pain is trying to prevent you from doing happens anyways and you just end up with more damage. I'm telling you these alternatives…

They did not ask for health advice from random internet strangers. Trying to bully someone into following medical advice they didn't ask for is not cool.

Making a suggestion is “bullying” now?

Get a grip

Re: New insights into why aspirin works so well

#53

Post by DoreenMichele »

cfu28 wrote: post #36
DoreenMichele wrote: post #24

Tangentially, does anyone know how aspirin promotes bleeding? I've searched (and also searched nutrient depletions for aspirin) and I'm not really getting an answer.

Prevents arachidonic acid from being converted to thromboxane needed for platelet aggregation. Here's a diagram I find helpful of the arachidonic pathway and which drugs inhibit which parts of the pathway: https://files.mari.casa/aapathway.jpg

Thanks, I'm kind of stuck on the arachidonic acid bit. When I was very ill, I read a comment by a guy with a PhD in chemistry who probably typoed arachidic acid and ..ugh. I need to at some point sort a few things out.

Linoleic acid can be converted by the body into arachidonic acid, so that part I got right all those years ago.

Re: New insights into why aspirin works so well

#54

Post by DoreenMichele »

bigsparky wrote: post #52
DoreenMichele wrote: post #28

Earlier quoted context omitted.

They did not ask for health advice from random internet strangers. Trying to bully someone into following medical advice they didn't ask for is not cool.

Making a suggestion is “bullying” now? Get a grip

No, doubling down and trying to insist they take your advice after they said "No thank you" is bullying.

Re: New insights into why aspirin works so well

#55

Post by seattle_spring »

jamal-kumar wrote: post #25
zabzonk wrote: post #16

Earlier quoted context omitted.

thanks, but no thanks

There's something like a downward spiral into hell that is opiates which starts with low doses like what you're on and escalates into worse and worse bullshit because you're not even trying to treat the underlying inflammation before masking the pain with opiates, and then the movement the pain is trying to prevent you from doing happens anyways and you just end up with more damage. I'm telling you these alternatives…

"just try weed bro" is the absolute worst most condescending advice you can give to someone suffering from chronic pain who didn't ask for advice.

Do you really, really think someone just "went to opiates" before trying absolutely everything to identify and treat the underlying cause?

Re: New insights into why aspirin works so well

#56

Post by nobody9999 »

simianparrot wrote: post #45
nobody9999 wrote: post #41

Earlier quoted context omitted.

>It's shocking to me how we still refer to paracetamol and ibuprofen in the same breath when their relative risks are so different. And it's shocking to me how we still refer to paracetamol (Acetominophen for us USAians) and ibuprofen in the same breath, when paracetamol might as well be a sugar pill, for all the good it does and ibuprofen is the liniment of the gods!

Ibuprofen being an NSAID is high risk for anyone who’s had stomach ulcers due to its risks involved in causing GI bleeding. For people like me it’s simply not even an option.

>For people like me it’s simply not even an option.

Good. More for me. ;)

More seriously, you're absolutely right. Which is why even folks who can take ibuprofen should only do so within appropriate limits (IIUC, 2400mg/day maximum).

I have spinal issues (disc degeneration, stenosis) which have, in the past, caused serious amounts of pain. If that pain is acute and not too serious, ibuprofen has been a life saver for me. Naproxen sodium, acetaminophen and other NSAIDs have absolutely no effect on me.

Without ibuprofen, my life would be a nightmarishly painful endeavor. And so, while I do understand your circumstance (which sucks because NSAIDs are wonderful as analgesics, it's a shame you can't use them), those who ibuprofen can help is a much larger pool than those it harms.

Hopefully, one day we'll discover/invent analgesics which don't cause GI issues.

If that pain (usually sciatica) becomes chronic, ibuprofen isn't enough. When that's happened, I've ended up having epidural steroid injections[0] which knocks out that inflammation post-haste.

[0] https://paindoctor.com/faq-epidural-steroid-injections/

Edit: Fixed typo, removed extraneous text.

Re: New insights into why aspirin works so well

#57

Post by seattle_spring »

archerx wrote: post #39
DoreenMichele wrote: post #28

Earlier quoted context omitted.

They did not ask for health advice from random internet strangers. Trying to bully someone into following medical advice they didn't ask for is not cool.

[flagged]

You don't have any idea what you're talking about. Please stay in your lane

Re: New insights into why aspirin works so well

#58

Post by alkori »

zabzonk wrote: post #46
archerx wrote: post #39

Earlier quoted context omitted.

[flagged]

> how dare the other guy suggest alternatives that do not work

So I guess all that research from respected institutions like John Hopkins is just made up? Can you show me a peer reviewed study that would prove otherwise?

Re: New insights into why aspirin works so well

#59

Post by swidi »

11235813213455 wrote: post #47

I use nothing for reducing inflammation, nor any drugs since decades, when I'm ill from time to time (once or twice a year), I let the fever go, the body is just working actively, it's not especially uncomfortable

Yes, and everybody here thinks you're a brave little boy. Have a lollipop.

Re: New insights into why aspirin works so well

#60

Post by 9dev »

11235813213455 wrote: post #47

I use nothing for reducing inflammation, nor any drugs since decades, when I'm ill from time to time (once or twice a year), I let the fever go, the body is just working actively, it's not especially uncomfortable

The body handles inflammations just fine, but you can actively help it to get it done more quickly. Doesn't have to be Aspirin though, chamomile tea and lots of other things work wonders, too.
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