Transfusion of brain fluid from young mice improves memory in old mice

Post by inglor_cz » Thu, May 12, 2022, 7:14 PM UTC

dangerlibrary wrote: post #76

meowface wrote: post #67

Earlier quoted context omitted.

I think it's the exact opposite. The day being old is no longer a disease and a path to inevitable death will be one of the greatest things to ever happen to humanity, now and forever into the future. Especially if you can retain a youthful, healthy brain and body no matter how old you are. An old tyrannical movie villain dies and a to-be old tyrannical movie villain is born. Billions of people shouldn't be sentenced…

Pretty sure the possible world being lamented in the GP comment is not "everyone gets to live forever and stay healthy and youthful" but instead "there exist expensive, parasitic procedures which will allow some rich people to have drastically extended lifespans."

Post by mleonhard » Thu, May 12, 2022, 7:28 PM UTC

s1artibartfast wrote: post #47

ninesnines wrote: post #5

this above article is kind of inflammatory, however, this paper is incredibly interesting. I read it this morning and the concept of changing CSF in order to have an increase in oligodendrocyte progenitor cell proliferation and differentiation is such a creative idea; a lot of the idea has focused on increasing flow in order to move waste, etc with csf. I think this concept that CSF is also acting as an important mec…

Modifying CSF turnover is not particularly novel, but I do think it is generally overlooked. CSF production cycling is greatly reduced in the elderly and and there are a lot of connections to memory diseases such as alzheimers. A few medical device startups have attacked the problem with promising results. Unfortunately, VC and national funding orgs aren't particularly interested in device based solutions because pil…

Post by ntoskrnl » Thu, May 12, 2022, 7:35 PM UTC

sitkack wrote: post #20

pengaru wrote: post #19

Earlier quoted context omitted.

This isn't my area of expertise at all. A personal experience that comes to mind is when my childhood cat developed kidney disease. She drank plenty of water, urinated excessively, and her blood still became toxic without regular (~daily) intervention in the form of adding saline to her blood intravenously. Like a light switch she'd resume normal life after the saline bag emptied into her blood, then slowly become il…

You must have loved that cat very much.

Post by noneeeed » Thu, May 12, 2022, 7:41 PM UTC

candiddevmike wrote: post #22

pengaru wrote: post #13

Haven't similar things been observed with blood transfusions of young blood into the elderly, which was then found to actually be unnecessary - even just diluting the blood with something neutral and clean produced similar results. "The solution to pollution is dilution"

All the more reason to donate blood.

Post by noneeeed » Thu, May 12, 2022, 7:46 PM UTC

spacephysics wrote: post #51

In before the AJ people start saying “see?! Adrenochromes!” Surely this will give more fuel to the conspiratorial fire.