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Israel’s Covid-19 boosters are preventing infections, new studies suggest

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Re: Israel’s Covid-19 boosters are preventing infections, new studies suggest

#301

Post by raxxorrax »

gerbilly wrote: post #299

I'm starting to feel that when people protest things they disagree with that it has less to do with the actual issue than with a desire to voice a contrary opinion in general. I suspect that the opposition—even anger sometimes—is a lot less about vaccines, or abortion than some other unmet need that finds expression though this kind of opposition. And I also think that even discussing these issues with the intent to…

It is reactionary for the most part and certainly the animosity towards those advertising vaccines is more important than the vaccine itself.

The people more actively trying to educate others are in it for their own form of therapy. Their fear lets them ride the soothing assurance of authoritarianism. They are safe if everyone is one the right level. I wouldn't call that well intentioned for the most part.

I fear irrationality isn't vaccine-able. It is a serious disease and people should take care. It is actually quite a privilege if you could get a free vaccine, other people might be glad about that.

On the other hand, people that got the disease just plainly shouldn't take it and business requiring me to be vaccinate and identify myself can search for other customers. People have to accept that others are less fearful than themselves.

Re: Israel’s Covid-19 boosters are preventing infections, new studies suggest

#302

Post by rsfern »

manofmanysmiles wrote: post #271
hwillis wrote: post #207

Earlier quoted context omitted.

> Therefore the claim that an injection of RNA could modify your DNA is possible. Absolutely not. This is like saying water is a neurotoxin because a tiny subset of neurotoxins contain water. Or that almost any food can modify your dna, since mRNA, RNA and DNA are in any cells you eat. reverse transcription doesn't just happen . Retroviruses work because they carry reverse transcriptase: https://en.wikipedia.org/wiki…

I’m not saying the vaccines do this, just that it’s theoretically possible to make a gene therapy that does modify DNA.

A gene therapy, sure. After all, that is the basis of CRISPR gene editing [0].

One of the key differences is the mRNA vaccines are not delivered with the necessary enzymes to actually cleave and splice DNA, e.g. [1].

0: https://en.m.wikipedia.org/wiki/CRISPR_gene_editing 1: https://en.m.wikipedia.org/wiki/Cas9

Re: Israel’s Covid-19 boosters are preventing infections, new studies suggest

#303

Post by dgfitz »

fendy3002 wrote: post #300
dgfitz wrote: post #223

Earlier quoted context omitted.

So ~0.004% then. Are you suggesting that is statistically significant?

I'll get downvoted, but people keep forgetting that covid spread is exponential, not linear.

Ok, 0.008% if you want. Sure feels like an argument for argument sake. I can find a list of odds of things that will hurt/kill a 20-something where the percentage is greater than 0.008 if you'd like.

Re: Israel’s Covid-19 boosters are preventing infections, new studies suggest

#304

Post by vfclists »

hackingforfun wrote: post #73

I'm pretty surprised to still see some misinformation in some of the posts here. I have a friend who has a PhD in molecular biology and she described the mRNA vaccines to me. The mRNA is only a piece of the spike protein, and does not enter the cell's nucleus. It only interacts with the cytoplasm. Normally, if a cell had to deal with an actual SARS-CoV-2 virus, it would be dealing with the spike proteins and the enti…

What is this paper saying then?

SARS-CoV-2 RNA reverse-transcribed and integrated into the human genome

https://pubmed.ncbi.nlm.nih.gov/33330870/

Re: Israel’s Covid-19 boosters are preventing infections, new studies suggest

#305

Post by leoedin »

sim_card_map wrote: post #150
hackingforfun wrote: post #131

Earlier quoted context omitted.

> If the chance of me getting hospitalized is so low to begin with I just don't think this is true. Again, look at the states in the US with the lowest levels of vaccination. They are running out of ICU beds due to the amount of cases. I'm not sure where you're located. Maybe there's a low amount of cases there, but in general, the risk of being hospitalized (and maybe not having a bed to go to) is rather high. The d…

It is true. There's an Oxford Covid risk calculator, and for an average 20 something person, the risk of hospitalization is ~0.002%. https://qcovid.org/

That calculator isn't telling you the risk of hospitalisation per case, but the risk of hospitalisation over a 90 day period during the first peak of the pandemic.

The two are very different. The calculated risk includes the fact that not everyone (or even most people) will get covid during that 90 day window. It's also based on the statistics for the original covid variant - by all accounts Delta is both more transmissible and more likely to cause hospitalisation.

The likelihood on a per-case basis is significantly higher. The Economist has a tool here: https://www.economist.com/graphic-detail/covid-pandemic-mort...

For example, a 25 year old man with no co-morbidity who receives a positive covid test has a 1.6% chance of hospitalisation. Obviously not everyone with covid will receive a positive test (I've seen an estimate of 1 in 4 are tested) - so perhaps that rate is actually 0.4%. That's way, way higher than the 0.002% you said.

Ultimately if covid is endemic, you will get it. At that point, even as a 25 year old, you're risking hospitalisation.

Re: Israel’s Covid-19 boosters are preventing infections, new studies suggest

#306

Post by leoedin »

dgfitz wrote: post #223
mrtesthah wrote: post #169

Earlier quoted context omitted.

Has this been updated for the delta variant which is estimated be twice as likely to cause hospitalization? https://www.politico.eu/article/delta-coronavirus-variant-do...

So ~0.004% then. Are you suggesting that is statistically significant?

That calculator includes an estimate of likelihood of catching covid - so the actual risk of hospitalisation for someone who does catch covid is way, way higher - for a 25 year old man in the US it's about 1.6%.

https://www.economist.com/graphic-detail/covid-pandemic-mort...

Re: Israel’s Covid-19 boosters are preventing infections, new studies suggest

#307

Post by leoedin »

gilbetron wrote: post #259
NalNezumi wrote: post #123

Earlier quoted context omitted.

I have never ever on HN seen an argument about DNA and mRNA, but then again I don't follow the conversation too much. As it seems like you know someone with correct background on the subject, so I wanted to ask you something I've always wanted to know as a young,(late 20s) healthy person with no existing risky precondition in this pandemic: Why should I take a vaccine, when it is now known that vaccinated people can…

Think of it this way, you have two choices: 1. You have a 0.0001% risk of death, and a 0.001% risk of hospitalization, and will maybe spread covid to 5-8 people. Long term effects unknown. 2. You have a 0.00001% risk of death, and a 0.0001% risk of hospitalization, and will maybe spread covid to 1-2 people. Long term effects unknown. Which choice would you take? (note the 2nd option is a conservative estimate of the…

The risk of hospitalisation for most people who get covid is way higher than 0.01% - it's about 1% for a 21 year old man, 2.7% for a 30 year old man and 8.5% for a 50 year old man - and only goes up from there.

https://www.economist.com/graphic-detail/covid-pandemic-mort...

Re: Israel’s Covid-19 boosters are preventing infections, new studies suggest

#308

Post by kderbyma »

uniqueid wrote: post #279
ostenning wrote: post #250

Earlier quoted context omitted.

Personally, my heart & chest are still recovering from the second Pfizer shot, after having ECG, bloodwork and nearly going to the ER. Wont be getting a booster, thats for damned certain. I suspect the number to be significantly higher than whats reported.

Literally billions of people around the world have been vaccinated against Coronavirus now. How high can the chance of serious short-term side effects be?

lol that's the same logic that resulted in 100M passwords and credentials being leaked....again and again and again.....

mistakes are normal, to assume none is truly unfathomably dense....

Re: Israel’s Covid-19 boosters are preventing infections, new studies suggest

#309

Post by sudosysgen »

gerbilly wrote: post #299

I'm starting to feel that when people protest things they disagree with that it has less to do with the actual issue than with a desire to voice a contrary opinion in general. I suspect that the opposition—even anger sometimes—is a lot less about vaccines, or abortion than some other unmet need that finds expression though this kind of opposition. And I also think that even discussing these issues with the intent to…

Congratulations, you have discovered reactionary politics. When people feel like society is not going right and that they're missing something that abstractly they had at some point in the past, you get mindsets like these.

Re: Israel’s Covid-19 boosters are preventing infections, new studies suggest

#310

Post by disgruntledphd2 »

raducu wrote: post #64
JumpCrisscross wrote: post #50

Earlier quoted context omitted.

> Is there any reason not to increase vaccine production rates so we have the capacity to vaccinate the world population faster than every 9 months? Capital constraints. Most specifically, human capital. mRNA production methods, including for critical precursors, are complicated. There is a limited number of people who can build and monitor the productions systems.

There are countries filled with idiots,like my lovely Romania where 70% of people don't want to get vaccinated, and we have to sell/donate millions and millions of doses.

The Irish population (including myself) are very grateful for this :) Kinda sucks for Romania though.
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