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Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate

pfizer.com

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Re: Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate

#131

Post by pfdietz »

swalsh wrote: post #51
honksillet wrote: post #28

Earlier quoted context omitted.

Does anyone know why they haven't released a Delta varient vaccine? Is seems that it would just involved we changing the mRNA sequence in a computer at the factor, but I'm really just guessing. Also maybe it is considered a whole new vaccineand needs to go through approval again.

I think our approval processes haven't kept up with the technology. The existing vaccine is already approved, and boosters seem to have some beneficial affects.

If the GOP weren't so foolish against vaccines, they could have made hay criticizing the slowness of the FDA.

Re: Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate

#132

Post by shawnz »

pibechorro wrote: post #42
_Microft wrote: post #14

Prepare to read the headline "mRNA vaccine trial for " a lot in the future. My guess is that they are going to produce mRNA versions of basically any vaccine (and then some) in the future. The nice thing about the technology seems to be that you only need to exchange the mRNA payload while the surrounding delivery method can be reused. That makes it not only a fast method to create a vaccine but a very convenient way…

We should not call them vaccines, they work totally different. These are gene treatments.

I am curious about this line of thinking. If you believe that mRNA vaccines should be considered "gene treatments" then why don't you also believe that traditional vaccines are "gene treatments"? What exactly makes one fall under that description but not the other?

Re: Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate

#133

Post by shawnz »

walidwalid wrote: post #79
jhrmnn wrote: post #67

Earlier quoted context omitted.

Absolutely not correct. They do work exactly like conventional vector vaccines, the only difference is how the genetic material of the foreign virus is delivered to the cells of the patient. The genetic material of the patient (the genes) is not modified.

Can you guarantee that and sign with your own blood ?

What does that mean exactly? Is that the standard by which you hold other medical treatments to as well?

Re: Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate

#134

Post by sambe »

ad404b8a372f2b9 wrote: post #44
sambe wrote: post #37

Earlier quoted context omitted.

"These claims were investigated by the FDA and the Centers for Disease Control, which found no connection between the vaccine and the autoimmune complaints."

That's already written in the comment I replied to.

Yes, of course, but you then appeared to query the "unfounded" nature of the claims. I thought you had missed the part where they turned out to be indeed unfounded.

Re: Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate

#135

Post by bxrxdx »

harshreality wrote: post #122
kingkawn wrote: post #58

Earlier quoted context omitted.

One bad autoimmune reaction from a poorly engineered vaccine and the whole society will boycott the mRNA vaccines forever after. Safety is higher priority to ongoing viability than speed.

But it doesn't make sense in this context. They're literally changing nothing except the mRNA sequence. If a new vaccine is made by taking a gene sequence from a virus protein that's already in the wild, and packaging it into a delivery mechanism (LNP) that's already approved for another vaccine... If there are any strange reactions to the new spike protein, that would also be caused by the wild virus spike protein,…

Right, all you're changing is the mRNA, but that can still be really dangerous. What if you code for a protein that causes cross-reactivity with a human protein and you give millions of people an auto-immune disorder?

I'm 1000% pro mRNA vaccines and pro covid vaccines, but they still need to be tested.

Re: Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate

#138

Post by wil421 »

nyolfen wrote: post #117
amyjess wrote: post #91

Earlier quoted context omitted.

At the beginning of the pandemic, people theorized that public health will influence future media for a generation, much like WW2 did. For decades, we got war TV shows, war movies, war comics, etc. Hogan's Heroes ran into the '70s, Sgt. Rock was published until the late '80s, and so on. And I think we're about to see the same with media based on public health efforts. One of the things that'll come out of this is tha…

> At the beginning of the pandemic, people theorized that public health will influence future media for a generation, much like WW2 did. For decades, we got war TV shows, war movies, war comics, etc. Hogan's Heroes ran into the '70s, Sgt. Rock was published until the late '80s, and so on. And I think we're about to see the same with media based on public health efforts. but we actually won that war, which precipitate…

WW2 had the Red Scare, Japanese interment camps, and shocking amounts of human experimentation. I would like to hear about the fear mongering and downright lies that were going on during WW2 from someone who was there. I’d bet there was lots of misinformation going around, social media has made those types of things flourish.

If you look back at history through rose-tinted glasses everything will appear better than it was.

Re: Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate

#139

Post by quasarsunnix »

nyolfen wrote: post #117
amyjess wrote: post #91

Earlier quoted context omitted.

At the beginning of the pandemic, people theorized that public health will influence future media for a generation, much like WW2 did. For decades, we got war TV shows, war movies, war comics, etc. Hogan's Heroes ran into the '70s, Sgt. Rock was published until the late '80s, and so on. And I think we're about to see the same with media based on public health efforts. One of the things that'll come out of this is tha…

> At the beginning of the pandemic, people theorized that public health will influence future media for a generation, much like WW2 did. For decades, we got war TV shows, war movies, war comics, etc. Hogan's Heroes ran into the '70s, Sgt. Rock was published until the late '80s, and so on. And I think we're about to see the same with media based on public health efforts. but we actually won that war, which precipitate…

To be fair this war isn’t over yet and WW2 wasn’t exactly a walk in the park for any allied power.

Re: Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate

#140

Post by bxrxdx »

bart_spoon wrote: post #124
honksillet wrote: post #28

Earlier quoted context omitted.

Does anyone know why they haven't released a Delta varient vaccine? Is seems that it would just involved we changing the mRNA sequence in a computer at the factor, but I'm really just guessing. Also maybe it is considered a whole new vaccineand needs to go through approval again.

One reason is because they've found that simply boosting with the original mRNA gives a massive spike in protection even against Delta, apparently on par with variant specific versions of the vaccine. Another is that recent studies are showing that natural infection provides much more comprehensive, long-lasting immunity against all variants than the vaccination does, while vaccination with the current vaccines offer…

I haven't seen any research that says that infection acquired immunity is stronger or longer lasting than from vaccine. The opposite in fact.
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