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Had Covid? You’ll probably make antibodies for a lifetime

nature.com

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Re: Had Covid? You’ll probably make antibodies for a lifetime

#311

Post by anonymouse008 »

__blockcipher__ wrote: post #300
Scoundreller wrote: post #297

Earlier quoted context omitted.

The vaccines (so far) all use sequences of the spike protein from an early sample of COVID-19. They just make spike proteins and your body sees it and becomes immune to it. They've made some modifications, but for better stability/structure outside of the virus, but not (yet) to address variants. If anything, infection from current circulating virus is more relevantly effective (but obviously more dangerous than the…

Yes exactly this. Naturalistic immunity learns a more diverse set of epitopes. Whereas the artificial-spike-protein immunity is learning just the S protein. The spike is super important but it’s not the only source of epitopes. And I’ve seen some papers on immunology of SARS-2 that do show a lot of activity that’s not based around the spike protein. This notion that natural immunity is “worse” or won’t be able to han…

Aye, I’d much rather fight the bull head on than play matador

Re: Had Covid? You’ll probably make antibodies for a lifetime

#312

Post by ReptileMan »

tw04 wrote: post #64
heyflyguy wrote: post #40

I am being shunned by my family because of my lack of interest in the vaccine. I've had COVID and recovered. I also don't get a flu shot each year. I really like not putting things into my body, especially when year after year I may or may not "catch" these things but if I do, I always recover. I act responsibly and do not go out when I am sick. However, none of these facts or articles such as this will ever effectiv…

>I act responsibly and do not go out when I am sick. With the flu for instance, you are communicable before you show symptoms. Were you wearing a mask for the duration of the flu season prior to covid? That would be what responsible looks like if you're not interested in getting a shot. >I have continuously been near or around folks that have come down with Covid and have yet to encounter a second infection or positi…

The critical is infecting at what rate and for the flue how communicable. You cannot define responsible without quantified chances.

The article you have given is written by people that haven't given a single probability number. But they declare that it is unsafe. Declaring un/safety without measuring risk is senseless.

Re: Had Covid? You’ll probably make antibodies for a lifetime

#313

Post by flarg »

seren wrote: post #86

From my understanding if you had an mRNA vaccine, your body was only exposed to an artificial spike protein, so effectively you have spike specific antibodies. On the other hand, if you had a real infection by the virus, you likely have antibodies for the spike protein and other part of the virus like the shell. So from my layman understanding, the immunity should be more resistant to a mutation of the spike protein.…

Your evidence is contradicting your opinion!

Re: Had Covid? You’ll probably make antibodies for a lifetime

#314

Post by plank_time »

jonnycomputer wrote: post #289
xienze wrote: post #261

Earlier quoted context omitted.

> It almost seems like a lot of people don't want the data to indicate that natural immunity is strong and long lasting, even though the data shows that reinfection is extemely rare. I too remember when the concept of "natural immunity to Covid" was a wild, dangerous conspiracy theory, along with the "came out of the Wuhan lab" theory. Funny watching the narrative change in real time.

Natural immunity is great. If you survive. And if you don't give it to others. Almost impossible not to give it to others. Relying on it was pretty reckless, especially given how little we understand it.

This statement is overly alarmist. 98% of people survive covid. >85% are asymptomatic or have mild symptoms. The vast majority of people survive without any issues. The biggest problem with covid is how infectious it is, which is what really overwhelms health care systems.

Re: Had Covid? You’ll probably make antibodies for a lifetime

#315

Post by Xplune13 »

DarknessFalls wrote: post #283
ultralite wrote: post #258

Earlier quoted context omitted.

Natural immunity was used as a justification for some societal responses, particularly by some on one side of the political spectrum. Thus, some of those on the opposite side will interpret strong natural immunity to COVID-19 as a political loss.

Remember that across the globe, there are many complex political affiliations. As it turns out, the governments that tend to be more authoritarian, such as India, the U.K., or the U.S. during the last cycle, denied the efficacy of wearing masks or getting vaccinated. Boris Johnson went as far as to suggest he get Covid on stage with the cameras rolling, to show the dangers were exaggerated. Now he's well on his way t…

Don't know about the U.K or the U.S. but saying Indian Govt. denied the efficacy of wearing masks is false. The Indian Govt. had some questionable reaction to the pandemic but they never denied efficacy of wearing masks and vaccinations. On the contrary they actually encouraged people to wear masks and get vaccinated as fast as possible (when there were plenty of vaccines that is).

Re: Had Covid? You’ll probably make antibodies for a lifetime

#316

Post by plank_time »

DarknessFalls wrote: post #281
loveistheanswer wrote: post #189

It almost seems like a lot of people don't want the data to indicate that natural immunity is strong and long lasting, even though the data shows that reinfection is extemely rare. Similar to how so many people have been unwilling to even consider a lab leak was a possibility, until just now it seems, because that idea was heresy to the orthodox dogma that ordained Scientists are Saviors. Humans have equated sickness…

Anecdotally, I've known at least three people who have caught Covid twice during the pandemic. This runs contrary to your statement that natural immunity "is strong and long lasting". Rather, it is a forgetful, fickle thing to rely upon. Get vaccinated.

Anecdotally, I don’t know anyone personally who has gotten COVID. That doesn’t mean that I discount science and don’t believe that it exists.

Reinfection is extremely low otherwise it would have shown itself in the data. That’s really a simple fact.

Re: Had Covid? You’ll probably make antibodies for a lifetime

#317

Post by wheels »

loveistheanswer wrote: post #189

It almost seems like a lot of people don't want the data to indicate that natural immunity is strong and long lasting, even though the data shows that reinfection is extemely rare. Similar to how so many people have been unwilling to even consider a lab leak was a possibility, until just now it seems, because that idea was heresy to the orthodox dogma that ordained Scientists are Saviors. Humans have equated sickness…

It's been very interesting to me listening particularly to American podcasts and the extent to which the American left equates Covid rules to piety. You can here that there's significant genuine resistantance to the idea of letting go of the restrictions as they've become part of identity.

I'm American, but I've lived in Germany for the last 20 years. Here, vaccines are being used as the carrot to be able to get rid of the restrictions (like mask wearing, limiting of contacts, etc.). It feels like everyone wants to get rid of the restrictions here, and it's more of a fight about who gets to do that first and why.

Re: Had Covid? You’ll probably make antibodies for a lifetime

#318

Post by swader999 »

barrkel wrote: post #267
ultralite wrote: post #257

Earlier quoted context omitted.

Isn't this the sort of study and conclusion that would give weight to "herd immunity"? To you, is there any study/conclusion that would allow us to propose solutions like "herd immunity"?

By that, I presume you mean sit back and do nothing, and let 'immunity' arise from infections. That doesn't work with Covid because the mortality rate is too high and the infection rate leads to healthcare being overwhelmed. If there was evidence that the mortality rate was low (but we have evidence of the opposite) or that the infection rate didn't spike upwards and start clogging up the beds that hospitals have whi…

It will work fine for younger populations though.

Re: Had Covid? You’ll probably make antibodies for a lifetime

#319

Post by jeremyjh »

randomopining wrote: post #250
koolba wrote: post #238

Earlier quoted context omitted.

What if you have the vaccine, and then get exposed to the actual virus? Would it be the best of all worlds as the existing antibodies would prevent a full on infection but your body would also learn more generalized attacks against the virus? Or would it not be enough exposure to warrant the latter?

That’s what I think and is why I actually wanted to get the virus 2+ weeks after vaccination.

You want to get the virus so that in the future you don't...get the virus?

Re: Had Covid? You’ll probably make antibodies for a lifetime

#320

Post by Scoundreller »

hanklazard wrote: post #292
pengaru wrote: post #245

Earlier quoted context omitted.

I thought it was sort of the other way around; that your immune system is keying into some fairly random and subjective set of dna features on the specific viral strain you've been infected with. But that with the mRNA vaccines, your body is being explicitly taught about the spike protein, nothing more, nothing less. So provided any future infection employs a spike protein, you have immunity. The question is, what ar…

Based on work from similar coronaviruses, the spike protein was quickly identified at the beginning of the pandemic as an important component for viral binding to the ACE-2 receptor. It is one protein component of the viral shell, but has proven to be an excellent target, given its induced immune response to the mRNA vaccines. Covid will not be able to mutate away from using the spike protein, but it will continue to…

> You may have heard about monoclonal antibody therapies to covid ... those, unfortunately, are very susceptible to mutation because if a critical targeted residue mutates, you could lose all efficacy of the drug.

Depends if the therapy works on the virus itself, or your body's response to the infection.

I think most of the monoclonal antibodies are working on your body's (over)response, so mutations shouldn't change much. Same with corticosteroids.

But Nucloside/tide analogues on the other hand or anything else working against viral processes/replication, oh yeah.

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