Hacker News Board Hacker News, browsed like a classic message board
Live data from Hacker News

Fructose reprogrammes glutamine-dependent oxidative metabolism to support LPS

nature.com

Post reply on HN
Print view View original

81–90 of 110 posts

Re: Fructose reprogrammes glutamine-dependent oxidative metabolism to support LPS

#81

Post by jonnycomputer »

leephillips wrote: post #45
akurzon wrote: post #43

For anyone interested in a detailed explanation of fructose metabolism (and why it's bad for you), I'd highly recommend these two talks by Robert Lustig on the subject. The first one is about how the body reacts to fructose, and the second video is a follow-up that emphasizes how fructose has contributed to the obesity epidemic in the US and elsewhere. https://youtu.be/dBnniua6-oM https://youtu.be/ceFyF9px20Y

But don’t all other primates eat lots of fruit? Why are humans unique?

I guess my first thought is: the amount of fructose in fruit is small relative to the amount in, say, a cola. Also, fiber might mitigate the insulin response. Also, we aren't eating fruits found in the wild (which is the relevant ecological context for this discussion). We have selectively bred fruits to be bigger and sweeter.

Re: Fructose reprogrammes glutamine-dependent oxidative metabolism to support LPS

#82

Post by m463 »

binarymax wrote: post #4

I wonder if we’ll ever see HFCs regulated like tobacco or alcohol. It’s another one of those epic scandals by huge corporations that used propaganda to sway public opinion...and now we’re left with an obesity epidemic.

A lot of hospital cafeterias will not serve any drinks with hfcs.

Re: Fructose reprogrammes glutamine-dependent oxidative metabolism to support LPS

#84

Post by pirate787 »

sprayk wrote: post #9
binarymax wrote: post #4

I wonder if we’ll ever see HFCs regulated like tobacco or alcohol. It’s another one of those epic scandals by huge corporations that used propaganda to sway public opinion...and now we’re left with an obesity epidemic.

If we (in the US) could end corn subsidies, use of HFCS in food production would probably fall naturally as other sweeteners were able to compete again for the cheapest sweetener.

Actually HFCS are entirely a product of the US Sugar program, which among other things restricts importation of sugar to drive up the price of domestic sugar. In the 1980s this made HFCS from milling corn into a cheaper liquid substitute for sugar. Thats when the soft drinks switched over. HFCS historically cost more to make than sugar but is made competitive only by govt intervention in the sugar market. If the US had market access to global sugar HFCS would not be competitive, Americans pay 5x more for sugar which creates the opening for HFCS.

Re: Fructose reprogrammes glutamine-dependent oxidative metabolism to support LPS

#85

Post by jonnycomputer »

galangalalgol wrote: post #40
electrograv wrote: post #27

Earlier quoted context omitted.

Question: Does this mean honey and high fructose corn syrup are approximately equally [1] unhealthy? Or is honey an anomaly/enigma [2] in this respect? [1] Apparently honey contains ~40% fructose, which about the same as “HFCS42” (a standard 42% fructose corn syrup product). [2] I ask this because I’ve read many claims that honey is among the healthiest forms of sugar, with many studies cited that show all sorts of h…

It sounds to me like fruit itself is implicated, so honey certainly would be. My rule is, anything that tastes sweet is probably bad for me, but I have some digestive issues. I would like to do nothing but greens, oily fish and some roots to round out the calories, but I am weak willed.

Don't worry about fruit.

If I recall, studies of holistic health almost always find that eating fruit is good for you.

I'm sure the quantity and concentration of fructose matters too.

Re: Fructose reprogrammes glutamine-dependent oxidative metabolism to support LPS

#86

Post by bitwize »

TaupeRanger wrote: post #76

Ah, another meaningless nutrition epidemiology study done on rats and ex vivo cells in a dish that tells us precisely nothing about how the health of actual humans is affected (if at all).

It's further confirmation that the highly addictive toxic white powder pushed on the public by evil cartels we should really worry about is not cocaine, but sugar. Do you drink soda? Put sugar in your coffee? Well, the first step is admitting you have a problem.

Re: Fructose reprogrammes glutamine-dependent oxidative metabolism to support LPS

#87

Post by core-questions »

poopoopeepee wrote: post #67
germinalphrase wrote: post #51

Earlier quoted context omitted.

My point is availability doesn’t follow. That it has a functionally infinite shelf life means that the seasonality of production is not relevant. I can go to my big box grocery store and buy several honeys that are produced within 50 miles of my Midwestern city. I can buy several more that are produced elsewhere. Year round.

> rare and seasonal in nature I don't know what else to add. You've gone too far off the path. It's pretty simple what OP wrote. Makes a person think about nature, evolution, adaption, is-this-healthy. Ok?

You know what it makes me think? You're chasing extremely marginal gains in life expectancy.

Yes, there's a good chance that in the caveman days I would only have had honey in rare circumstance when I found a good beehive and had time to process it. It would have been consumed fairly quickly unless I had extremely advanced levels of time preference and self control.

I also would probably have been dead by my mid-30s.

Now, I can get high quality, delicious, dark local honey - a year's supply at a tablespoon a day, more than you need - for less than what the average HN poster makes in an hour.

I don't eat that much of it, usually just use it as a maple syrup substitute for a nice weekend breakfast, and should be able to live until my 80s as long as I keep in shape with some basic exercise on a regular basis.

> You've gone too far off the path.

What path, friend? Where is the path? Where are the markings, and who put them there?

There is no path.

Re: Fructose reprogrammes glutamine-dependent oxidative metabolism to support LPS

#88

Post by bitwize »

knuthsat wrote: post #68
akurzon wrote: post #43

For anyone interested in a detailed explanation of fructose metabolism (and why it's bad for you), I'd highly recommend these two talks by Robert Lustig on the subject. The first one is about how the body reacts to fructose, and the second video is a follow-up that emphasizes how fructose has contributed to the obesity epidemic in the US and elsewhere. https://youtu.be/dBnniua6-oM https://youtu.be/ceFyF9px20Y

Those videos have been debunked. Lustig used a lot of false claims.

Which claims are false? I wouldn't trust any "debunking" with big sugar money behind it.

Re: Fructose reprogrammes glutamine-dependent oxidative metabolism to support LPS

#89

Post by leephillips »

4ec0755f5522 wrote: post #65
leephillips wrote: post #45

Earlier quoted context omitted.

But don’t all other primates eat lots of fruit? Why are humans unique?

Does fruit contain as much fructose today as it did 50, 100, 200 years ago? Or have we selectively bread the sweetest fruits to the point where monkeys cannot eat bananas? Monkeys banned from eating bananas at Devon zoo Zookeepers say the stereotypical food actually makes monkeys more aggressive, rots their teeth and can lead to diabetes [...] Zookeepers said the fruit grown and exported for human consumption have fa…

This is interesting! And I love bananas, too.

Re: Fructose reprogrammes glutamine-dependent oxidative metabolism to support LPS

#90

Post by knuthsat »

bitwize wrote: post #88
knuthsat wrote: post #68

Earlier quoted context omitted.

Those videos have been debunked. Lustig used a lot of false claims.

Which claims are false? I wouldn't trust any "debunking" with big sugar money behind it.

There's no big sugar behind it. You can quite easily see that a bunch of studies are on isolates, the Japanese he mentions eat much less calories and more fructose as a percentage of calories, etc.

There's just too much inaccuracies and outright misrepresentation to fit the narrative

Post reply on HN