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Fructose reprogrammes glutamine-dependent oxidative metabolism to support LPS

nature.com

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Re: Fructose reprogrammes glutamine-dependent oxidative metabolism to support LPS

#61

Post by scns »

galangalalgol wrote: post #40
electrograv wrote: post #27

Earlier quoted context omitted.

Question: Does this mean honey and high fructose corn syrup are approximately equally [1] unhealthy? Or is honey an anomaly/enigma [2] in this respect? [1] Apparently honey contains ~40% fructose, which about the same as “HFCS42” (a standard 42% fructose corn syrup product). [2] I ask this because I’ve read many claims that honey is among the healthiest forms of sugar, with many studies cited that show all sorts of h…

It sounds to me like fruit itself is implicated, so honey certainly would be. My rule is, anything that tastes sweet is probably bad for me, but I have some digestive issues. I would like to do nothing but greens, oily fish and some roots to round out the calories, but I am weak willed.

Use pure Glucose?

Re: Fructose reprogrammes glutamine-dependent oxidative metabolism to support LPS

#62

Post by rirze »

leephillips wrote: post #45
akurzon wrote: post #43

For anyone interested in a detailed explanation of fructose metabolism (and why it's bad for you), I'd highly recommend these two talks by Robert Lustig on the subject. The first one is about how the body reacts to fructose, and the second video is a follow-up that emphasizes how fructose has contributed to the obesity epidemic in the US and elsewhere. https://youtu.be/dBnniua6-oM https://youtu.be/ceFyF9px20Y

But don’t all other primates eat lots of fruit? Why are humans unique?

I was told that most fruits have a comparable amount of fructose and glucose and that eating excess fructose is what causes diseases and autoimmune reactions.

Re: Fructose reprogrammes glutamine-dependent oxidative metabolism to support LPS

#63

Post by galangalalgol »

scns wrote: post #61
galangalalgol wrote: post #40

Earlier quoted context omitted.

It sounds to me like fruit itself is implicated, so honey certainly would be. My rule is, anything that tastes sweet is probably bad for me, but I have some digestive issues. I would like to do nothing but greens, oily fish and some roots to round out the calories, but I am weak willed.

Use pure Glucose?

Its not the sweets that I break down for, its cured meats and cheeses, and occasionally I want grains really badly.

Re: Fructose reprogrammes glutamine-dependent oxidative metabolism to support LPS

#64

Post by [deleted] »

tp3 wrote: post #28
foxyv wrote: post #10

Earlier quoted context omitted.

Table sugar is entirely made up of sucrose. A polymer which is composed of one glucose molecule and one fructose molecule. Fructose is also in most fruit sugars. Honey is one of the worst offenders from a natural source. Finally corn syrup is the absolute worst. Avoiding refined sugars in general is a good thing, but removing fructose completely would require not eating any fruits or berries either. The rule of thumb…

I think most Americans are doing just fine with high fructose diets. However, there have been a lot of studies coming out, that seem to be suggesting there is some danger of obesity after a certain low carbohydrate diet or skipping carbohydrates altogether, as these diets tend to spike blood sugar rapidly. The most interesting is a study in humans, that showed a significant increase in blood glucose when carbohydrate…

[deleted]

Re: Fructose reprogrammes glutamine-dependent oxidative metabolism to support LPS

#65

Post by 4ec0755f5522 »

leephillips wrote: post #45
akurzon wrote: post #43

For anyone interested in a detailed explanation of fructose metabolism (and why it's bad for you), I'd highly recommend these two talks by Robert Lustig on the subject. The first one is about how the body reacts to fructose, and the second video is a follow-up that emphasizes how fructose has contributed to the obesity epidemic in the US and elsewhere. https://youtu.be/dBnniua6-oM https://youtu.be/ceFyF9px20Y

But don’t all other primates eat lots of fruit? Why are humans unique?

Does fruit contain as much fructose today as it did 50, 100, 200 years ago? Or have we selectively bread the sweetest fruits to the point where monkeys cannot eat bananas?

Monkeys banned from eating bananas at Devon zoo

Zookeepers say the stereotypical food actually makes monkeys more aggressive, rots their teeth and can lead to diabetes

[...]

Zookeepers said the fruit grown and exported for human consumption have far higher levels of sugar than the ones monkeys would eat in the wild – to the point that it’s bad for their teeth and can lead to diabetes.

https://www.independent.co.uk/news/uk/home-news/monkeys-bann...

Re: Fructose reprogrammes glutamine-dependent oxidative metabolism to support LPS

#66

Post by poopoopeepee »

airhead969 wrote: post #57
poopoopeepee wrote: post #37

Earlier quoted context omitted.

Its production is seasonal. Availability follows. Ok?

Well, can't we buy some and keep it? I know the fresh stuff is tasty, but let's not go Winnie the Pooh. :)

> rare and seasonal in nature

I don't know what else to add. You've gone too far off the path. It's pretty simple what OP wrote. Makes a person think about nature, evolution, adaption, is-this-healthy. Ok?

Re: Fructose reprogrammes glutamine-dependent oxidative metabolism to support LPS

#67

Post by poopoopeepee »

germinalphrase wrote: post #51
poopoopeepee wrote: post #36

Earlier quoted context omitted.

Its production is seasonal. Availability follows. Ok?

My point is availability doesn’t follow. That it has a functionally infinite shelf life means that the seasonality of production is not relevant. I can go to my big box grocery store and buy several honeys that are produced within 50 miles of my Midwestern city. I can buy several more that are produced elsewhere. Year round.

> rare and seasonal in nature

I don't know what else to add. You've gone too far off the path. It's pretty simple what OP wrote. Makes a person think about nature, evolution, adaption, is-this-healthy. Ok?

Re: Fructose reprogrammes glutamine-dependent oxidative metabolism to support LPS

#68

Post by knuthsat »

akurzon wrote: post #43

For anyone interested in a detailed explanation of fructose metabolism (and why it's bad for you), I'd highly recommend these two talks by Robert Lustig on the subject. The first one is about how the body reacts to fructose, and the second video is a follow-up that emphasizes how fructose has contributed to the obesity epidemic in the US and elsewhere. https://youtu.be/dBnniua6-oM https://youtu.be/ceFyF9px20Y

Those videos have been debunked. Lustig used a lot of false claims.

Re: Fructose reprogrammes glutamine-dependent oxidative metabolism to support LPS

#69

Post by knuthsat »

cjbenedikt wrote: post #53
leephillips wrote: post #45

Earlier quoted context omitted.

But don’t all other primates eat lots of fruit? Why are humans unique?

If you eat an apple for example yes, it contains fructose. Eating or drinking something with corn syrop is like eating LOTS of apples. Which you normally wouldn't do. https://www.healthline.com/nutrition/is-fruit-good-or-bad-fo...

Eating the equivalent amount of apples to HFCS is never going to have the same effect. Fiber content and other good stuff will completely remove the effects that you might see fructose isolate.

Re: Fructose reprogrammes glutamine-dependent oxidative metabolism to support LPS

#70

Post by dmfdmf »

admash wrote: post #52
nayuki wrote: post #23

Earlier quoted context omitted.

HFCS is a misnomer. It's just 55% fructose and 45% glucose. Whereas sucrose is exactly 50% fructose and 50% glucose. HFCS is a health problem, but not not more so than sugar already. Balancing free fructose does not matter because by eating starch, you are already intaking much more glucose than fructose.

High-fructose corn syrup is not a misnomer. It is in contrast to ordinary corn syrup which consists almost entirely of glucose along with smaller amounts its oligo-saccharides (e.g. maltose, etc). Corn syrup generally contains no fructose. To be precise, HFCS-55 is 55% fructose. Commonly used varieties of HFCS include HFCS-42, HFCS-55, and HFCS-90, containing the percentages of fructose indicated by the number, thoug…

I think you missed the point, moreover the article you cited actually supports the parent comment (note the italicized sentences).

> However, diets containing large amounts of sucrose, high fructose corn syrup, or fructose alone, overwhelm the ability of the small intestine to metabolize it all and under these conditions a significant amount of fructose is then metabolized by the liver and to a lesser extent by other organs such as skeletal muscle. It should be pointed out that the difference between the amount of fructose available from sucrose obtained from cane or beet sugars is not significantly less than that from corn syrup. Corn syrup is somewhat improperly identified as high fructose corn syrup (HFCS) giving the impression that it contains a large amount of fructose. However, whereas the fructose content of sucrose is 50% (since it is a pure disaccharide of only glucose and fructose), the content in HFCS is only 55% and in many cases is actually only 40-45% fructose. The reason that corn syrup (which is all glucose to begin with) is labeled as HFCS is because the glucose extracted from corn starch is enzymatically treated to convert some of the glucose to fructose. This is done in order to make the sugar sweeter which is why it is particularly popular in the food industry. Therefore, any disorder and/or dysfunction (see below), attributed to the consumption of fructose, can be manifest whether one consumes cane or beet sugar, HFCS, or pure fructose such as in honey and most fruits.

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