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Fructose reprogrammes glutamine-dependent oxidative metabolism to support LPS

nature.com

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Re: Fructose reprogrammes glutamine-dependent oxidative metabolism to support LPS

#71

Post by pkaye »

leephillips wrote: post #45
akurzon wrote: post #43

For anyone interested in a detailed explanation of fructose metabolism (and why it's bad for you), I'd highly recommend these two talks by Robert Lustig on the subject. The first one is about how the body reacts to fructose, and the second video is a follow-up that emphasizes how fructose has contributed to the obesity epidemic in the US and elsewhere. https://youtu.be/dBnniua6-oM https://youtu.be/ceFyF9px20Y

But don’t all other primates eat lots of fruit? Why are humans unique?

I wonder if the enzyme uricase has anything to do with it. While reading about gout, I read that uricase is not found in humans, chimpanzees, gorillas, orangutans and gibbons but is found in other primates. Apparently uricase is found in most animals except the above. And somehow uricase is also related to fructose processing.

Re: Fructose reprogrammes glutamine-dependent oxidative metabolism to support LPS

#72

Post by core-questions »

TACIXAT wrote: post #48
tp3 wrote: post #28

Earlier quoted context omitted.

I think most Americans are doing just fine with high fructose diets. However, there have been a lot of studies coming out, that seem to be suggesting there is some danger of obesity after a certain low carbohydrate diet or skipping carbohydrates altogether, as these diets tend to spike blood sugar rapidly. The most interesting is a study in humans, that showed a significant increase in blood glucose when carbohydrate…

>I think most Americans are doing just fine with high fructose diets. Most Americans are overweight. I wouldn't call that doing fine.

Well, they're prepared for a famine, and since you can live till your late 60s or later while being horrendously out of shape, "fine" is a relative thing, no?

Re: Fructose reprogrammes glutamine-dependent oxidative metabolism to support LPS

#73

Post by ASalazarMX »

4ec0755f5522 wrote: post #65
leephillips wrote: post #45

Earlier quoted context omitted.

But don’t all other primates eat lots of fruit? Why are humans unique?

Does fruit contain as much fructose today as it did 50, 100, 200 years ago? Or have we selectively bread the sweetest fruits to the point where monkeys cannot eat bananas? Monkeys banned from eating bananas at Devon zoo Zookeepers say the stereotypical food actually makes monkeys more aggressive, rots their teeth and can lead to diabetes [...] Zookeepers said the fruit grown and exported for human consumption have fa…

This was very unexpected, thank you for the link.

Re: Fructose reprogrammes glutamine-dependent oxidative metabolism to support LPS

#74

Post by foxyv »

nradov wrote: post #13
foxyv wrote: post #10

Earlier quoted context omitted.

Table sugar is entirely made up of sucrose. A polymer which is composed of one glucose molecule and one fructose molecule. Fructose is also in most fruit sugars. Honey is one of the worst offenders from a natural source. Finally corn syrup is the absolute worst. Avoiding refined sugars in general is a good thing, but removing fructose completely would require not eating any fruits or berries either. The rule of thumb…

Honey appears to have some other beneficial properties. There is no real evidence that moderate honey consumption causes worse health outcomes.

Honey in small quantities is probably just fine like table sugar or maple syrup. But keep in mind that it's 4:3 ratio of fructose to glucose. In addition is has a ton of minerals and organic compounds thought to be beneficial. But if you drink it in your tea every day you will be taking in a lot of fructose.

Re: Fructose reprogrammes glutamine-dependent oxidative metabolism to support LPS

#75

Post by foxyv »

airstrike wrote: post #25
foxyv wrote: post #10

Earlier quoted context omitted.

Table sugar is entirely made up of sucrose. A polymer which is composed of one glucose molecule and one fructose molecule. Fructose is also in most fruit sugars. Honey is one of the worst offenders from a natural source. Finally corn syrup is the absolute worst. Avoiding refined sugars in general is a good thing, but removing fructose completely would require not eating any fruits or berries either. The rule of thumb…

Berries have very little sugar. https://www.healthline.com/health/best-low-sugar-fruits

Yup! So enjoy them! They are one of my favorite treats. If you don't crush them and only drink the juice and you should be fine. Also don't eat more than 2 cups in a single sitting or drench them in sugar and you should be fine. They are also great with heavy whipping cream.

Re: Fructose reprogrammes glutamine-dependent oxidative metabolism to support LPS

#78

Post by m463 »

leephillips wrote: post #45
akurzon wrote: post #43

For anyone interested in a detailed explanation of fructose metabolism (and why it's bad for you), I'd highly recommend these two talks by Robert Lustig on the subject. The first one is about how the body reacts to fructose, and the second video is a follow-up that emphasizes how fructose has contributed to the obesity epidemic in the US and elsewhere. https://youtu.be/dBnniua6-oM https://youtu.be/ceFyF9px20Y

But don’t all other primates eat lots of fruit? Why are humans unique?

I think fruits in nature probably have a lot more water and are manually picked and eaten which limits the speed and quantity of intake.

Meanwhile humans can eat concentrated fruits. Imagine picking and eating 100 grapes, vs eating a handful of raisins.

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