At this point, is there anything not linked to Alzheimer’s? Herpes does make sense as a plausible factor, but I feel like I read “X linked to Alzheimer’s” every few months.
Using human brain tissue in lab, researchers show herpes link to Alzheimer’s
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Re: Using human brain tissue in lab, researchers show herpes link to Alzheimer’s
#92Earlier quoted context omitted.
On the other hand... https://lee-phillips.org/isrealPediatrics/
Well, it's good to see they're slowly modernizing this, but in the end it's still a pretty bizarre practice even if you don't do it in that particularly disgusting way. Not an American, and always wondered how it somehow became the standard in America....
It by "it" you mean circumcision, it was thought to be good for hygiene. But these days it is no longer routine, as it was a few decades ago.
Re: Using human brain tissue in lab, researchers show herpes link to Alzheimer’s
#93Thank you for sharing this! We are working on the genomics of AD
Re: Using human brain tissue in lab, researchers show herpes link to Alzheimer’s
#94Earlier quoted context omitted.
What's your gameplan for the rest of your life? You're never going to kiss anyone or share a cup or a smoke or any of the thousands of ways that have infected the vast majority of humanity? You can even get it passing through your mom's birth canal. Your two examples of transmission are so specific that I'm not sure you know how it spreads. Just extended family members kissing or sharing cups with your kids? What? He…
I'm in the second half of my life and I married an HSV-negative. I try not to put my mouth on sketchy things.
You "married an HSV-negative"? Quite the romantic.
Re: Using human brain tissue in lab, researchers show herpes link to Alzheimer’s
#95HSV always seemed particularly poorly understood in the society to me, e.g. with many people getting it as children due to careless parents/extended family, and the benign branding of "cold sore" as if it is related to a cold. Given that the vaccine for 1 or 2 has proved to be extremely challenging, always wondered if the public simply being more well-informed on this topic could help reduce the incidence in the popu…
> careless parents/extended family > benign branding of "cold sore" This is a dangerous, hurtful opinion and you need to be downvoted. No one is to be shamed for this virus. A third of teenagers will acquire HSV-1 during childhood from simply putting things into their mouths. There is no way to prevent this sort of transmission. [1] Most of the world's population has the virus. [2] Given these odds, you probably have…
The statement "There is no way to prevent this sort of transmission" while linking CDC data that shows changes in the trend of transmission over time are at odds to me.
There are most definitely ways to reduce spread.
>The focus should be on finding a cure, not changing social norms or shaming people.
There is no cure yet, thus changing habits and social norms is our only chance at reducing this problem outside experts who are working on the problem directly.
I don't know whether or not labeling parents as villains has anything to do with what needs to be done to label and reduce spread; but I dare say that the attitude of "Nothing to be done, let's give up due to the fact that the virus is prevalent." is in fact the dangerous opinion for society at large.
>... and you need to be downvoted.
The call to arms for down-voting a comment you disagree is a tactic that I personally feel is cheap and a disgusting misuse of the karma/discourse system that is in place.
Re: Using human brain tissue in lab, researchers show herpes link to Alzheimer’s
#96HSV always seemed particularly poorly understood in the society to me, e.g. with many people getting it as children due to careless parents/extended family, and the benign branding of "cold sore" as if it is related to a cold. Given that the vaccine for 1 or 2 has proved to be extremely challenging, always wondered if the public simply being more well-informed on this topic could help reduce the incidence in the popu…
> careless parents/extended family > benign branding of "cold sore" This is a dangerous, hurtful opinion and you need to be downvoted. No one is to be shamed for this virus. A third of teenagers will acquire HSV-1 during childhood from simply putting things into their mouths. There is no way to prevent this sort of transmission. [1] Most of the world's population has the virus. [2] Given these odds, you probably have…
Yeah, shaming is counterproductive. But I have to disagree with one of your points: changing social norms.
Changing social norms can be have huge benefits. Very timely example is that social norms are likely a major reason so many Asian countries have much lower Covid-19 infection rates than western countries. If only Americans could get over themselves and stop shaking hands and wearing their shoes in the house. I say that as an American expat.
Re: Using human brain tissue in lab, researchers show herpes link to Alzheimer’s
#97Here's the original publication. The paper is actually more focused on the 3d engineered brain model and is titled "A 3d human brain-like tissue model of herpes-induced Alzheimer's disease": https://advances.sciencemag.org/content/6/19/eaay8828 The publication actually seems to highlight the demonstration of the 3d brain Alzheimers model as more of what the accomplishment of the paper is (as compared to a demonstrati…
Thanks for linking that, the first thing I wondered when they said "herpes" was "which one"? Looks like the answer to that is herpes simplex virus type I (HSV-1)
Also relevant:
> “Active [herpes] infection may not be a requirement for Alzheimer’s disease,” Kaplan and his colleagues wrote. A history of herpes infection might be “sufficient to initiate Alzheimer’s.”
> But not in everyone. An estimated two-thirds of people 50 and younger are infected with HSV-1. Although nothing close to that number will develop Alzheimer’s from a virus or anything else, scientists aren’t sure what combination of genetics, lifestyle, and other factors determines who will.
Re: Using human brain tissue in lab, researchers show herpes link to Alzheimer’s
#98Earlier quoted context omitted.
> careless parents/extended family > benign branding of "cold sore" This is a dangerous, hurtful opinion and you need to be downvoted. No one is to be shamed for this virus. A third of teenagers will acquire HSV-1 during childhood from simply putting things into their mouths. There is no way to prevent this sort of transmission. [1] Most of the world's population has the virus. [2] Given these odds, you probably have…
Yeah, shaming is counterproductive. But I have to disagree with one of your points: changing social norms. Changing social norms can be have huge benefits. Very timely example is that social norms are likely a major reason so many Asian countries have much lower Covid-19 infection rates than western countries. If only Americans could get over themselves and stop shaking hands and wearing their shoes in the house. I s…
... Americans wear their shoes in the house? I'm a (non-white) American and this is news to me. Whenever someone comes to my house, or I go to someone else's house, people leave their shoes at the door. I thought this was something that pretty much everyone from every part of the world did.
Re: Using human brain tissue in lab, researchers show herpes link to Alzheimer’s
#99Earlier quoted context omitted.
What's your gameplan for the rest of your life? You're never going to kiss anyone or share a cup or a smoke or any of the thousands of ways that have infected the vast majority of humanity? You can even get it passing through your mom's birth canal. Your two examples of transmission are so specific that I'm not sure you know how it spreads. Just extended family members kissing or sharing cups with your kids? What? He…
>You're never going to kiss anyone or share a cup or a smoke or any of the thousands of ways that have infected the vast majority of humanity? Sounds reasonable I am 30 and have never kissed anyone, and no plans to change that soon. Although I had some shared cups. I probably should get tested. But there is a good change I have avoided all herpes, even EBV. I hope they can find a vaccine soon.
If we all stopped having sex, that would admittedly solve the issue of all disease rather thoroughly. No people, no human Herpes infections.
Re: Using human brain tissue in lab, researchers show herpes link to Alzheimer’s
#100I am very curious to see where this research goes. At the risk of sounding like an absolute nut-case, I've been experiencing significant cognitive decline since getting divorced and becoming sexually active. Granted, I went through a traumatic experience(divorce), developed sleep apnea(treated for ~2 years), and am in my mid-40s, so my concerns are probably unfounded. That said, I've had my apnea under control for so…
I have a similar experience except younger but the antiviral doesn't seem to do much for cognitive decline IME. I'm waiting to get jaw surgery in the hope of ditching CPAP.