Using human brain tissue in lab, researchers show herpes link to Alzheimer’s
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Re: Using human brain tissue in lab, researchers show herpes link to Alzheimer’s
#2Big if true! This would mean that just as the Gardasil 9 vaccine prevents HPV, which leads to almost all forms of cervical cancer [1] (as well as others), a vaccine for HSV-1 might prevent someone from developing Alzheimer's later in life.
There are HSV-2 vaccines in clinical trials [2], but I'm unaware of any HSV-1 vaccines as far along. Please chime in if you are aware!
[1] https://www.nccc-online.org/hpvcervical-cancer/cervical-canc...
Re: Using human brain tissue in lab, researchers show herpes link to Alzheimer’s
#3So what does this mean if you get a cold sore every year or two? You're more likely to get Alzheimer's?
Re: Using human brain tissue in lab, researchers show herpes link to Alzheimer’s
#4So what does this mean if you get a cold sore every year or two? You're more likely to get Alzheimer's?
It means you’re not getting enough lysine at those times.
Re: Using human brain tissue in lab, researchers show herpes link to Alzheimer’s
#5Re: Using human brain tissue in lab, researchers show herpes link to Alzheimer’s
#6So according to WHO, 67% of people older than 50 have Herpes 1: https://www.who.int/en/news-room/fact-sheets/detail/herpes-s...
How do you account for the disparity between the massive infection rate and the relatively low Alzheimer's rate?
Re: Using human brain tissue in lab, researchers show herpes link to Alzheimer’s
#7So according to WHO, 67% of people older than 50 have Herpes 1: https://www.who.int/en/news-room/fact-sheets/detail/herpes-s... How do you account for the disparity between the massive infection rate and the relatively low Alzheimer's rate?
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Re: Using human brain tissue in lab, researchers show herpes link to Alzheimer’s
#8Earlier quoted context omitted.
It means you’re not getting enough lysine at those times.
Source on info? Can you supplement with lysine?
No (I think). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461191/
Re: Using human brain tissue in lab, researchers show herpes link to Alzheimer’s
#9Here's the original publication. The paper is actually more focused on the 3d engineered brain model and is titled "A 3d human brain-like tissue model of herpes-induced Alzheimer's disease":
https://advances.sciencemag.org/content/6/19/eaay8828
The publication actually seems to highlight the demonstration of the 3d brain Alzheimers model as more of what the accomplishment of the paper is (as compared to a demonstration of a herpes/Alzheimers link). Studying Alzheimer's is really difficult because the mouse models etc that we have today are particularly poor for this disease case, which means we can barely rely on any preclinical work done in these models in determing whether or not a drug is going to work in clinical trials. Better models to study Alzheimer's will be very important in fighting the disease. For more publications on the 3d model, here is what the paper cited in its methods section for how they made the brain-like structures:
https://www.sciencedirect.com/science/article/pii/S221367111...
Re: Using human brain tissue in lab, researchers show herpes link to Alzheimer’s
#10Big if true! This would mean that just as the Gardasil 9 vaccine prevents HPV, which leads to almost all forms of cervical cancer [1] (as well as others), a vaccine for HSV-1 might prevent someone from developing Alzheimer's later in life. There are HSV-2 vaccines in clinical trials [2], but I'm unaware of any HSV-1 vaccines as far along. Please chime in if you are aware! [1] https://www.nccc-online.org/hpvcervical-c…
This paper only shows that brain-like lab grown tissue develops Amyloid-beta plaques (known to occur in patients with AD) to combat mircobial i.e. viral attack.
There are a low of assumptions here: (1) Organoid tissue represents human-brain. Human (and mammalian) brain is a much more complex entity to be even remotely similar to this. (2) We do not know how amyloid-beta plaques are related to Alzheimer's Disease (AD) i.e. whether they are the cause of AD or a symptom that occurs when one has AD. All we know is the existence of these plauqes can occur before the symptoms of AD are seen (even upto 30 years before you are diagnoised with AD). Whether removal of plaques makes you AD free is a mystery. (3) HSV/Herpes virus might not be the only cause of formation of amyloid plauqes. There are tons of other microbial infections that have been shown to cause increase of plaques.
But more research into the microbial theory of AD is definitely something that would shed more light on the interplay between microbes and the brain.