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Using human brain tissue in lab, researchers show herpes link to Alzheimer’s

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Re: Using human brain tissue in lab, researchers show herpes link to Alzheimer’s

#51

Post by azernik »

vikramkr wrote: post #28
nostromo wrote: post #14

This is my primary concern with SARSCoV2. Seeing how HPV can manifest in cancer, how HSV-1 can lead to Alzheimer’s, or how VZV (chickenpox) can flare up later in life as Shingles. Edit: thanks for the helpful information below!

So far, the coronaviruses don't seem to establish latency in the same way that HPV does. And the chickenpox virus, VZV, is actually also a herpesvirus, along with the Epstein Barr virus and CMV (you might know them as mono), and all those viruses share the characteristics of having latent forms that persist and can re-emerge. While we need to keep our eyes open with SARS-COV-2, especially on cases of potential re-eme…

Indeed, the long-term effects I've seen researchers express more concern over are simpler. The disease causes quite a lot of damage to the lungs and circulatory system, and messes with brain oxygen levels. Not all of that damage is easily repaired by the body.

Re: Using human brain tissue in lab, researchers show herpes link to Alzheimer’s

#52

Post by roter »

nostromo wrote: post #14

This is my primary concern with SARSCoV2. Seeing how HPV can manifest in cancer, how HSV-1 can lead to Alzheimer’s, or how VZV (chickenpox) can flare up later in life as Shingles. Edit: thanks for the helpful information below!

Sort of tangential but interesting article in Economist [0] (based on [1]) that links the increased mortality of 28-year-olds of the Spanish flu with the Russian flu 28 years earlier, i.e. when they were born.

[0] https://www.economist.com/science-and-technology/2020/04/25/...

[1] https://www.ncbi.nlm.nih.gov/pubmed/23940526

Re: Using human brain tissue in lab, researchers show herpes link to Alzheimer’s

#53

Post by bsder »

vikramkr wrote: post #9

Here's the original publication. The paper is actually more focused on the 3d engineered brain model and is titled "A 3d human brain-like tissue model of herpes-induced Alzheimer's disease": https://advances.sciencemag.org/content/6/19/eaay8828 The publication actually seems to highlight the demonstration of the 3d brain Alzheimers model as more of what the accomplishment of the paper is (as compared to a demonstrati…

This is good because it helps continue to break down the whole "amyloid hypothesis" stanglehold on Alzheimer's research and we might finally start seeing some progress.

This is not the whole story, but it's a ray of sunshine to get medical scientists moving in a another direction.

Re: Using human brain tissue in lab, researchers show herpes link to Alzheimer’s

#54

Post by tejtm »

mylons wrote: post #5
TheSpiceIsLife wrote: post #4

Earlier quoted context omitted.

It means you’re not getting enough lysine at those times.

Source on info? Can you supplement with lysine?

Only anecdotal, but yes.

Supplement before if I know I will be increasing UV exposure. e.g. visiting high desert

Visiting know stressful environment. (choose your own adventure)

Or if I think I might be starting to feel one coming on.

Outbreaks in the decades after are way down from outbreaks from the decades before, but please do remember correlation is not causation and becoming a person who can consider mitigation may be more significant then the particular ritual.

Oh and prescription anti-virals work wonders.

Re: Using human brain tissue in lab, researchers show herpes link to Alzheimer’s

#55

Post by hombre_fatal »

nsxwolf wrote: post #41
hn_throwaway_99 wrote: post #30

Earlier quoted context omitted.

> e.g. with many people getting it as children due to careless parents/extended family Puhleeze. HSV is present in the majority of the population. Branding parents as "careless" because their children get it is ridiculous.

Not letting family members kiss your kids on the mouth and not letting your kids use other people's cups/forks etc? If the entire population did this there would be fewer herpes infections. edit: the downvotes are interesting. If I had made the statement "We can take steps to reduce COVID-19 transmission" I can't imagine I'd get the same result. I can only assume that people really are ashamed of having herpes and ar…

What's your gameplan for the rest of your life? You're never going to kiss anyone or share a cup or a smoke or any of the thousands of ways that have infected the vast majority of humanity? You can even get it passing through your mom's birth canal.

Your two examples of transmission are so specific that I'm not sure you know how it spreads. Just extended family members kissing or sharing cups with your kids? What?

Herpes-1 is just part of the human condition. Time to get over it. Btw, odds are that you have it. And for your own sanity, don't worry -- it doesn't mean you were making out with your family nor their kids.

Re: Using human brain tissue in lab, researchers show herpes link to Alzheimer’s

#56

Post by Natsu »

vikramkr wrote: post #9

Here's the original publication. The paper is actually more focused on the 3d engineered brain model and is titled "A 3d human brain-like tissue model of herpes-induced Alzheimer's disease": https://advances.sciencemag.org/content/6/19/eaay8828 The publication actually seems to highlight the demonstration of the 3d brain Alzheimers model as more of what the accomplishment of the paper is (as compared to a demonstrati…

Thanks for linking that, the first thing I wondered when they said "herpes" was "which one"?

Looks like the answer to that is herpes simplex virus type I (HSV-1)

Re: Using human brain tissue in lab, researchers show herpes link to Alzheimer’s

#57

Post by TaylorAlexander »

toomuchtodo wrote: post #26
TaylorAlexander wrote: post #22

Earlier quoted context omitted.

I tend to feel like "fun speculation" around new science research feeds loads of incorrect information being spread. Which makes it not fun to me at all.

If you're getting your health information solely from Hacker News, without any additional research or critical thinking, you should probably not do that. I'm not a domain expert (Virologist or otherwise in medicine), nor do I pretend to be, and I qualified my statement at the top of the thread ("might"). Everything else in my comment was factual.

I just don’t think wild speculation about science is fun. What is fun to me about science is fact based exploration. Hypothesis is great and conjecture has its place, but wild conjecture is not fun to me. You can feel otherwise and that’s okay!

Re: Using human brain tissue in lab, researchers show herpes link to Alzheimer’s

#58

Post by nsxwolf »

hombre_fatal wrote: post #55
nsxwolf wrote: post #41

Earlier quoted context omitted.

Not letting family members kiss your kids on the mouth and not letting your kids use other people's cups/forks etc? If the entire population did this there would be fewer herpes infections. edit: the downvotes are interesting. If I had made the statement "We can take steps to reduce COVID-19 transmission" I can't imagine I'd get the same result. I can only assume that people really are ashamed of having herpes and ar…

What's your gameplan for the rest of your life? You're never going to kiss anyone or share a cup or a smoke or any of the thousands of ways that have infected the vast majority of humanity? You can even get it passing through your mom's birth canal. Your two examples of transmission are so specific that I'm not sure you know how it spreads. Just extended family members kissing or sharing cups with your kids? What? He…

I'm in the second half of my life and I married an HSV-negative. I try not to put my mouth on sketchy things.

Re: Using human brain tissue in lab, researchers show herpes link to Alzheimer’s

#59

Post by trianglem »

darawk wrote: post #50
clircle wrote: post #46

I do not like headlines that say 'scientists show link between x and y'. It sounds too causal. Rather, journalists should try to write 'scientists observed x correlates with y'

They didn't observe a correlation, though. They observed Herpes causing Alzheimers lesions in vitro.

It should be very easy to test for correlation though since both conditions are usually medically documented. If the correlation is not that high then this story probably doesn’t mean all that much.

Re: Using human brain tissue in lab, researchers show herpes link to Alzheimer’s

#60

Post by SketchySeaBeast »

tengbretson wrote: post #42
echelon wrote: post #40

Earlier quoted context omitted.

> careless parents/extended family > benign branding of "cold sore" This is a dangerous, hurtful opinion and you need to be downvoted. No one is to be shamed for this virus. A third of teenagers will acquire HSV-1 during childhood from simply putting things into their mouths. There is no way to prevent this sort of transmission. [1] Most of the world's population has the virus. [2] Given these odds, you probably have…

> This is a dangerous, hurtful opinion and you need to be downvoted. > No one is to be shamed for this virus. Don't care. If I'm going to get shamed for walking down the sidewalk without a mask then I sure as shit am going to shame an adult that kisses their child when they have an infectious sore on there face.

Or kisses their loved one when they are asymptomatic? The stigma around herpes is ridiculous.
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